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Determining method for 15 kinds of forbidden nitro imidazoles antibiotics in cosmetics

A technology for nitroimidazoles and determination methods, which can be applied to measurement devices, instruments, scientific instruments and other directions, and can solve problems such as drug resistance of nitroimidazoles, health risks, contact dermatitis, etc.

Inactive Publication Date: 2013-04-17
CHINESE ACAD OF INSPECTION & QUARANTINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Illegal addition of nitroimidazoles in acne cosmetics, although it may play a role in removing mites and acne in the short term, long-term use will irritate the skin, cause contact dermatitis, and in severe cases can lead to drug resistance to nitroimidazoles sex, causing health hazards

Method used

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  • Determining method for 15 kinds of forbidden nitro imidazoles antibiotics in cosmetics
  • Determining method for 15 kinds of forbidden nitro imidazoles antibiotics in cosmetics
  • Determining method for 15 kinds of forbidden nitro imidazoles antibiotics in cosmetics

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Embodiment Construction

[0042] For further illustrating the present invention, specifically illustrate in conjunction with following examples:

[0043] 1. Reagents and materials

[0044] 1 methanol, chromatographically pure.

[0045] 2 Acetonitrile, chromatographically pure.

[0046] 3 Ethanol, analytically pure.

[0047] 4 Formic acid, chromatographically pure.

[0048] 54-nitroimidazole, purity 97%.

[0049] 62-Metronidazole, purity 99%.

[0050] 7-Hydroxymetronidazole, purity 99.3%.

[0051] 8-Hydroxydimetridazole, purity 98.5%.

[0052] 9 Metronidazole, purity 99.5%.

[0053] 10 dimetidazole, purity 98.5%.

[0054] 11 ronidazole, purity 99.5%.

[0055] 12 Tenidazole, purity 99.8%.

[0056] 13 Metronidazole Clorox, with a purity of 98%.

[0057] 14 Bennidazole, purity 98.5%.

[0058] 15 secnidazole, purity 99.6%.

[0059] 16 tinidazole, purity 99.7%.

[0060] 17-Hydroxyisopronidazole with a purity of 99.8%.

[0061] 18 ornidazole, purity 98.5%.

[0062] 19 Pronidazole, purity 99.8%...

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Abstract

The invention relates to a determining method for 15 kinds of forbidden nitro imidazoles antibiotics in cosmetics. The determining method is characterized by comprising the step that a cosmetic sample is subjected to detection analysis by using a high-performance liquid chromatography-series quadrupole mass spectrometry after being subjected to supersonic extraction, high speed centrifugation and solid phase extraction. Compared with a parallelly operated standard sample of the 15 kinds of forbidden nitro imidazoles antibiotics such as metronidazole, the cosmetic sample disclosed in the invention is qualified by retention time and optimized monitoring ion pairs, is quantified by taking ions with a relatively high noise-signal ratio, a good peak form and low background interference as quantified ions, and then is subjected to external standard method quantification by using a standard curve. By utilizing the determining method, the detection speed is fast, and a result is accurate.

Description

technical field [0001] The invention relates to metronidazole, 4-nitroimidazole, 2-metronidazole, hydroxymetronidazole, hydroxydimethylnidazole, dimetidazole, ronidazole, tenidazole, chlorine Determination methods for 15 banned nitroimidazole antibiotics such as metronidazole, benzidazole, secnidazole, tinidazole, hydroxyisopronidazole, ornidazole, and ipronidazole. Background technique [0002] With the improvement of national living standards and people's pursuit of beauty, cosmetics, especially some daily skin care, whitening and cleaning products, have become indispensable necessities in people's daily life. Therefore, the safety of cosmetics has increasingly become a hot issue concerned by relevant departments and consumers. [0003] Nitroimidazole antibiotics are widely used to fight anaerobic infection, and also have certain curative effects on trichocysticosis, acne, and rosacea. Therefore, in order to enhance the anti-acne and whitening effects of cosmetics, some ...

Claims

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Application Information

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IPC IPC(8): G01N30/02G01N30/06
Inventor 马强孟宪双李文涛白桦陈云霞丁岚李晶瑞马会娟
Owner CHINESE ACAD OF INSPECTION & QUARANTINE
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