5 results about "Phosphatase inhibitor" patented technology

The present invention relates to a benzo ring-containing compound as a PTPN1 and / or PTPN2 inhibitor and use thereof, and particularly relates to a compound of formula (I), a tautomer thereof, a stereoisomer thereof, or a pharmaceutically acceptable salt thereof, a method for preparing same, and use thereof in the preparation of a medicament for treating a PTPN1 and / or PTPN2-related disease.

The invention relates to a benzoring-containing compound serving as a PTPN1 and / or PTPN2 inhibitor and application thereof, in particular to a compound shown in a formula (I), a tautomer, a stereoisomer or pharmaceutically acceptable salt of the compound, a preparation method of the compound, and application of the compound to preparation of drugs for treating PTPN1 and / or PTPN2 related diseases. (I)

The application belongs to the field of medicinal chemistry, and specifically discloses a kind of protein tyrosine phosphatase (PTPN) inhibitor as shown in formula I and enantiomers, diastereoisomers, tautomers or pharmaceutically acceptable salts thereof, a preparation method, a pharmaceutical composition and a pharmaceutical use thereof.The application also discloses a method for treating cancer, metabolic diseases and other related diseases using the protein tyrosine phosphatase inhibitor.I.

The disclosure is in part directed to crystalline forms of (R)-1'-(3 -(3,4-dihydro-1,5-naphthyridin-1(2H)-yl)-1H-pyrazolo[3,4- b|pyrazin-6-yl)-3H-spiro[benzofuran-2,4'-piperidin]-3 -amine, its salt, and variants thereof.

The present application relates to the technical field of pharmacy, in particular to application of compound Diaporterpene C in preparation of mycobacterium tuberculosis tyrosine phosphatase inhibitor. The present application provides application of compound Diaporterpene C in preparation of mycobacterium tuberculosis tyrosine phosphatase inhibitor, the compound can significantly inhibit the activity of key virulence factor tyrosine phosphatase MptpA and MptpB of mycobacterium tuberculosis, can be used as tyrosine phosphatase inhibitor with MptpA and / or MptpB as target, and can be further developed as anti-tuberculosis drug. The compound shows good anti-tuberculosis activity by inhibiting pathogenic signal pathway of pathogenic bacteria, and has important clinical application potential and development value in tuberculosis treatment.