Schizophyllan modified sodium hyaluronate microsphere gel, preparation method of sodium hyaluronate microsphere gel, and application of sodium hyaluronate microsphere gel in cosmetics

A technology of sodium hyaluronate and schizophyllan, applied in the direction of cosmetics, cosmetic preparations, medical preparations containing active ingredients, etc., can solve the problems of retention, difficulty in improving skin absorption rate and absorption effect, and achieve small size, Excellent moisture retention and small particle size

Inactive Publication Date: 2018-11-27
DONGGUAN LIANZHOU INTPROP OPERATION MANAGEMENT CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It can be known from the above-mentioned prior art that at present, sodium hyaluronate macromolecules are added or coated in materials physically, and most of the sodium hyaluronate macromolecules stay on the surface of the skin, making it difficult to significantly improve the skin's absorption rate and absorption effect

Method used

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  • Schizophyllan modified sodium hyaluronate microsphere gel, preparation method of sodium hyaluronate microsphere gel, and application of sodium hyaluronate microsphere gel in cosmetics

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] (1) In parts by weight, 1 part of sodium hyaluronate dry powder is added to an aqueous solution containing 0.001 part of hyaluronidase, and enzymatically hydrolyzed at 30°C for 20 minutes to obtain a small molecule of sodium hyaluronate of 2 μmoL / L solution, wherein the molecular weight of sodium hyaluronate is 100-250.

[0024] (2) Slowly add the sodium hyaluronate small molecule solution to the mixed oil phase at a rate of 5 μl / min, wherein the volume ratio of the sodium hyaluronate small molecule solution to the mixing tank is 1:40, and slowly stir at a rate of 25 r / min Finally, add a mixed cross-linking agent of calcium chloride and divinyl sulfone with a mass ratio of 1:0.6, the volume ratio of the cross-linking agent to the water phase is 3:1, and cross-link and solidify at 10°C for 4 hours to obtain micro-nano Grade Sodium Hyaluronate Microspheres.

[0025] (3) According to the mass ratio of sodium hyaluronate, schizophyllan and polyethylene glycol being 6:5:1, ...

Embodiment 2

[0027] (1) In parts by weight, 1 part of sodium hyaluronate dry powder is added to an aqueous solution containing 0.003 parts of hyaluronidase, and enzymatically hydrolyzed at 40°C for 30 minutes to obtain a small molecule of sodium hyaluronate of 5 μmoL / L solution, wherein the molecular weight of sodium hyaluronate is 100-250.

[0028] (2) Slowly add the sodium hyaluronate small molecule solution to the mixed oil phase at a rate of 10 μl / min, wherein the volume ratio of the sodium hyaluronate small molecule solution to the mixing tank is 1:50, and slowly stir at a rate of 80 r / min Finally, add a mixed cross-linking agent of calcium chloride and divinyl sulfone with a mass ratio of 1:0.8, the volume ratio of the cross-linking agent to the water phase is 4:1, and cross-link and solidify at 40°C for 6 hours to obtain micro-nano Grade Sodium Hyaluronate Microspheres.

[0029] (3) According to the mass ratio of sodium hyaluronate, schizophyllan and polyethylene glycol being 8:7:2...

Embodiment 3

[0031] (1) In parts by weight, 1 part of sodium hyaluronate dry powder is added to an aqueous solution containing 0.002 parts of hyaluronidase, and enzymatically hydrolyzed at 35°C for 23 minutes to obtain a small molecule of sodium hyaluronate of 3 μmoL / L solution, wherein the molecular weight of sodium hyaluronate is 100-250.

[0032] (2) Slowly add the sodium hyaluronate small molecule solution to the mixed oil phase at a rate of 8 μl / min, wherein the volume ratio of the sodium hyaluronate small molecule solution to the mixing tank is 1:45, and slowly stir at a rate of 50 r / min Finally, add a mixed cross-linking agent of calcium chloride and divinyl sulfone with a mass ratio of 1:0.7, the volume ratio of the cross-linking agent to the water phase is 3.5:1, and cross-link and solidify at 20°C for 4.5h to obtain micro Nanoscale sodium hyaluronate microspheres.

[0033] (3) According to the mass ratio of sodium hyaluronate, schizophyllan and polyethylene glycol of 7:6:1.2, sodi...

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Abstract

The invention provides schizophyllan modified sodium hyaluronate microsphere gel, a preparation method of the sodium hyaluronate microsphere gel, and application of the sodium hyaluronate microspheregel in cosmetics. The method comprises the following steps: adding dried sodium hyaluronate powder into a hyaluronidase solution, and performing enzymolysis to obtain a sodium hyaluronate small-molecule solution; slowly adding the sodium hyaluronate small-molecule solution into a mixed oil phase, slowly stirring, adding a mixed cross-linking agent of calcium chloride and divinyl sulfone, cross-linking and curing to obtain sodium hyaluronate microspheres; adding the sodium hyaluronate microspheres and pre-treated schizophyllan into an alkaline solution containing polyethylene glycol, uniformlystirring, regulating the pH value of the system to be neutral, adding a phosphate buffer solution, standing and aging, thereby obtaining the schizophyllan modified sodium hyaluronate microsphere gel.The schizophyllan modified sodium hyaluronate microsphere gel prepared by the method disclosed by the invention is small in particle size, easily penetrates into the deep part of skin, can form tiny gel with protein-water, achieves the effect of deeply moisturizing for a long time, and has excellent moisture retention property.

Description

technical field [0001] The invention belongs to the technical field of daily cosmetics, and in particular relates to a sodium hyaluronate microsphere gel modified by Schizophyllan, a preparation method thereof and an application in cosmetics. Background technique [0002] Sodium hyaluronate is the sodium salt form of hyaluronic acid. It is a high-molecular-weight straight-chain polysaccharide, which is formed by repeated alternating links of N-acetylglucosamine and glucuronic acid disaccharide units. It has high viscoelasticity and plasticity. , permeability and good biocompatibility, is internationally recognized as the best moisturizer. Sodium hyaluronate molecules have a highly stretched and random coil configuration in solution, and the molecular chains are intertwined to form a continuous network structure. Water molecules directly interact with sodium hyaluronate molecules through polar bonds and hydrogen bonds, making it transparent Sodium hyaluronate, like a molecul...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/73A61K8/04A61Q19/00
CPCA61K8/735A61K8/042A61K8/73A61K2800/412A61K2800/805A61Q19/00
Inventor 徐亚维
Owner DONGGUAN LIANZHOU INTPROP OPERATION MANAGEMENT CO LTD
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