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67 results about "Endotherm" patented technology

An endotherm (from Greek ἔνδον endon "within" and θέρμη thermē "heat") is an organism that maintains its body at a metabolically favorable temperature, largely by the use of heat set free by its internal bodily functions instead of relying almost purely on ambient heat. Such internally generated heat is mainly an incidental product of the animal's routine metabolism, but under conditions of excessive cold or low activity an endotherm might apply special mechanisms adapted specifically to heat production. Examples include special-function muscular exertion such as shivering, and uncoupled oxidative metabolism such as within brown adipose tissue. Only birds and mammals are extant universally endothermic groups of animals. Certain lamnid sharks, tuna and billfishes are also endothermic.

Temperature controlled sustained-release injection comprising alkyl agent and method for preparing the same

The invention relates to a temperature-controlled sustained-release injection containing an alkylating agent and a preparation method thereof, the temperature-controlled sustained-release injection comprises effective anti-cancer amount of the alkylating agent, an amphiphilic block copolymer, a solvent and a certain amount of drug release regulator, wherein, the mixture of the amphiphilic block copolymer and a solvent without organic solvent has the temperature-sensitive gelatinization feature, which is flowable liquid in the environment that is lower than the body temperature and can be automatically converted to the water-insoluble gel that can not flow and be biodegradable for absorption in an endotherm, and the water-insoluble gel can allow the contained angiogenesis inhibitor to have the local sustained release in a tumor and maintain the effective drug concentration for a plurality of weeks to a plurality of months. The sustained-release gel injection can be injected in the tumor or the tumor periphery or be arranged in the postoperative tumor cavity, thus significantly reducing the systemic reaction of the drug and being used for the treatment of the tumors in different stages. The alkylating agent is selected from cyclophosphamide, melphalan, leukeran, 4H-cyclophosphamide peroxide, norcantharidin, mannosulfan, treosulfan, ritrosulfan, ethoglucid, pipobroman, piposulfan, pumitepa, uredepa, azatepa and so on.
Owner:SHANDONG LANJIN PHARMA +1

Water injection high-frequency endotherm knife for operations

The invention provides a water injection high-frequency endotherm knife for operations. The water injection high-frequency endotherm knife comprises a shell and a metal endotherm knife head arranged at the head end of the shell. The endotherm knife head is electrically connected with a circuit board in the shell. The circuit board is connected with a wire arranged at the tail end of the shell. The side wall of the shell is provided with an electric resection key and an electric coagulation key which are electrically connected with the circuit board. A metal injection syringe needle is also arranged at the head end of the shell, or a metal injection syringe needle replacing the metal endotherm knife head is arranged at the head end of the shell. The tail end of the metal injection syringe needle is connected with an injection hose, made of insulating materials, in the shell, the side wall of the shell is further provided with a water injection switch structure capable of controlling on-off of the injection hose, and the other end of the injection hose is guided out through the tail end of the shell. According to the water injection high-frequency endotherm knife for the operations, tissue cutting efficiency and the fine degree can be improved in many ways, fine normal tissue like nerves is protected, the wound surface blood bleeding and seepage phenomena existing during operations and after operations are reduced, and therefore convenience is provided for surgical operations which are more fine and rapid.
Owner:XIN HUA HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE

Temperature controlled sustained-release injection containing anti-cancer medicine

The invention relates to a temperature-controlled sustained-release injection containing an anti-cancer drug, which consists of the anti-cancer drug and an amphiphilic block copolymer hydrogel and has the temperature-sensitive gelatinization feature, the temperature-controlled sustained-release injection is flowable liquid in the environment that is lower than the body temperature and can be automatically converted to the water-insoluble gel that can not flow and be biodegradable for absorption in an endotherm, thus allowing the drug to have the local sustained release in a tumor and maintain the effective drug concentration for a plurality of weeks to a plurality of months; the temperature-controlled sustained-release injection can be injected in the tumor or the tumor periphery or be arranged in the postoperative tumor cavity, thus significantly reducing the systemic reaction of the drug, strengthening the treatment effects of chemotherapy, radiotherapy and other non-surgical therapies, and being used for the treatment of the tumors in different stages. The anti-cancer drug can be vincristine, vinorelbine, navelbine, vindesine, vinleurosine, vinrosidine, cephalotaxine, bleomycin, daunomycin, aclarubicin, epirubicin, idarubicin, pirarubicin, valrubicin, mitomycin C, actinomycin D, losoxantrone, mitoxantrone, mitozolomide, temozolomide and so on.
Owner:SHANDONG LANJIN PHARMA +1

Temperature controlled sustained-release injection containing platinum compound

The invention relates to a temperature-controlled sustained-release injection containing a platinum compound and a preparation method thereof, the temperature-controlled sustained-release injection comprises effective anti-cancer amount of the platinum compound, an amphiphilic block copolymer and a certain amount of drug release regulator, wherein, the amphiphilic block copolymer is composed of polyethylene glycol and polyester, the mixture of the amphiphilic block copolymer and a solvent without organic solvent has the temperature-sensitive gelatinization feature, which is flowable liquid in the environment that is lower than the body temperature and can be automatically converted to the water-insoluble gel that can not flow and be biodegradable for absorption in an endotherm, and the water-insoluble gel can allow the contained platinum compound to have the local sustained release in a tumor and maintain the effective drug concentration for a plurality of weeks to a plurality of months; the anti-cancer sustained-release gel injection can be injected in the tumor or the tumor periphery or be arranged in the postoperative tumor cavity, thus being used for the treatment of the tumors in different stages. The platinum compound is selected from cisplatin, carboplatin, cycloplatin, eptaplatin, denaplatin, zeniplatin, enloplatin, sulfatodiaminocyclohexane platin, cis-spiroplatin, dexormaplatin, iproplatin, lobaplatin, miboplatin, picoplatin, nedaplatin, ormaplatin, oxaliplatin and so on.
Owner:SHANDONG LANJIN PHARMA +1
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