Temperature controlled sustained-release injection containing platinum compound

Abstract

The invention relates to a temperature-controlled sustained-release injection containing a platinum compound and a preparation method thereof, the temperature-controlled sustained-release injection comprises effective anti-cancer amount of the platinum compound, an amphiphilic block copolymer and a certain amount of drug release regulator, wherein, the amphiphilic block copolymer is composed of polyethylene glycol and polyester, the mixture of the amphiphilic block copolymer and a solvent without organic solvent has the temperature-sensitive gelatinization feature, which is flowable liquid in the environment that is lower than the body temperature and can be automatically converted to the water-insoluble gel that can not flow and be biodegradable for absorption in an endotherm, and the water-insoluble gel can allow the contained platinum compound to have the local sustained release in a tumor and maintain the effective drug concentration for a plurality of weeks to a plurality of months; the anti-cancer sustained-release gel injection can be injected in the tumor or the tumor periphery or be arranged in the postoperative tumor cavity, thus being used for the treatment of the tumors in different stages. The platinum compound is selected from cisplatin, carboplatin, cycloplatin, eptaplatin, denaplatin, zeniplatin, enloplatin, sulfatodiaminocyclohexane platin, cis-spiroplatin, dexormaplatin, iproplatin, lobaplatin, miboplatin, picoplatin, nedaplatin, ormaplatin, oxaliplatin and so on.

Description

(1) Technical field [0001] The invention relates to a temperature-controlled sustained-release injection containing platinum compounds, belonging to the technical field of medicines. Specifically, the invention relates to a slow-release gel preparation capable of stably releasing platinum compounds locally on solid tumors, mainly a slow-release gel injection. The slow-release gel preparation is an aqueous solution at room temperature and can It can become a semi-solid or solid gel in the body, so it can slowly release the contained platinum compounds locally in the tumor, from several days to several weeks. (2) Background technology [0002] Local application of chemotherapeutic drugs, especially local sustained release, has become the current research direction and focus of solid tumor chemotherapy. However, the current biodegradable sustained and controlled release preparations mostly use solid polymers such as polyglycolic acid, polylactic acid or their copolymers as sus...

AI Technical Summary

Problems solved by technology

Therefore, in most cases, the final sustained-release formulations are mostly solid shapes (eg, microspheres, tablets, or rods), which require a more complicated implantation process and are prone to tissue trauma and even tumor cell seeding or dissemination

In addition, organic solvents or high-heat processes often lead to the degradation and denaturation of many anti-cancer active ingredients, and solid implants cannot effectively cover the irregular tumor cavity after tumor resection. relapse