36 results about "Pirarubicin" patented technology

Disclosed is a compound anticancer slow release agent which comprises slow release microspheres and dissolvent, wherein the slow release microballoons comprise anti-cancer active constituents and slowrelease auxiliary materials, the dissolvent being specific dissolvent containing suspension adjuvant. The anticancer effective ingredients include Aclarubicin, Idarubicin, Doxorubicin, Epirubicin, Valtaxin, Pirarubicin, Losaxantrone, Losoxantrone and / or anticancer antibiotic synergistic agents selected from phosphoinositide-3-kinase inhibitor, pyrimidine analogues and / or DNA restoration enzymeinhibitor, the slow release auxiliary materials are selected from polylactic acid copolymer EVAc, or sebacic acid copolymer, the viscosity of the suspension adjuvant is 100-3000cp (at 20-30 deg C). The slow release microspheres can also be prepared into slow release implanting agent for lowering down the whole body toxicity reaction of the medicament when locally dispensing on the tumor, and for selectively increasing the tumor local medicinal concentration.

The invention relates to a preparation method for a Sappan Wood extract, in particular to a preparation process for Sappan Wood extract perfusate and application thereof in treating bladder cancer, which solves the problem of the application of the Sappan Wood extract in treating bladder cancer tumors. The preparation process comprises the following steps: taking and smashing Sappan Wood, carrying out water extracting for three times, combining the extracting solutions obtained by three-time water extracting, and carrying out decompression concentrating; standing overnight, and removing sediments; adding petroleum ether, extracting, and retaining aqueous phase; adding ethyl acetate, extracting, and removing the aqueous phase; carrying out decompression volatilizing to remove all the ethylacetate; weighing dry substances, adding purified water to enable the dry substance content to be 2%, heating for dissolving, standing overnight at room temperature, and filtering out sediments; and freeze-drying, and carrying out split charging. The experiment research result shows that the extract has obvious killing effect on bladder neoplasm cells; and compared with mitomycin, epirubicin, Pirarubicin and other anticancer drugs, which are clinically and frequently used, the Sappan Wood extract perfusate has the advantages of high anticancer activity, less toxicity, safety, effectiveness and the like.

An instant freeze-dried powder injection of pirarubicin is prepared from pirarubicin, excipient and cosolvent through proportionally dissolving them in the water for injection, aseptic filtering, loading in containers, and freeze-drying.

The invention belongs to the field of pharmaceutical preparations, and particularly relates to a magnetic pirarubicin nano-drug composite. The magnetic pirarubicin nano-drug composite comprises pirarubicin, an Fe3O4 nanoparticle and 3-aminopropyl triethoxysilane, wherein the particle diameter of the Fe3O4 nanoparticle is 10-100 nanometers. The magnetic pirarubicin nano-drug composite disclosed by the invention has good stability and dispersity and property of being positioned to a tumour part in a targeted way through an external magnetic field and reduces the toxic side effect on a normal structure by restricting the dual inhibiting effect of THP and Fe3O4 on a cell on a specific tumour part.