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Composition for treating the bladder cancer and application of hydrogen physiological saline

A technology of physiological saline and composition, applied in the field of medicine, can solve the problem of large side effects of bladder cancer perfusion, and achieve the effects of inhibiting the growth of bladder cancer cells, promoting tumor cell apoptosis, and good histocompatibility

Inactive Publication Date: 2019-11-19
SHENZHEN LUOHU PEOPLELS HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] The technical problem to be solved by the present invention is to provide a composition for treating bladder cancer and the application of hydrogen saline in order to solve the problem of large side effects of bladder cancer perfusion in the prior art.

Method used

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  • Composition for treating the bladder cancer and application of hydrogen physiological saline
  • Composition for treating the bladder cancer and application of hydrogen physiological saline
  • Composition for treating the bladder cancer and application of hydrogen physiological saline

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specific Embodiment

[0046] Preparation of hydrogen normal saline: Use a hydrogen generator or a hydrogen tank to ventilate for 1 hour, dissolve pure hydrogen in sterile normal saline to a saturated state, subpackage and store in medical centrifuge tubes, and store at normal pressure at 4 degrees Celsius.

[0047] Further, inject hydrogen into the normal saline at different time intervals, detect the hydrogen content in the normal saline after hydrogen injection, and the time it takes to reach hydrogen saturation. The specific results are as follows: figure 1 shown. After the hydrogen content in the normal saline reaches saturation, stop the flow of hydrogen, and detect the curve of the hydrogen content in the normal saline over time. The specific results are as follows: figure 2 shown. After passing hydrogen in normal saline for 5 minutes, the hydrogen content in the solution remains stable, reaching 0.8 ppm, and the content remains above 0.6 ppm within 6 hours. When injection or infusion is r...

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Abstract

The invention discloses a composition for treating the bladder cancer and application of hydrogen physiological saline. The composition includes hydrogen physiological saline and chemotherapeutic drugs, wherein the chemotherapeutic drugs are one or more of cisplatin, adriamycin, hydroxycamptothecin, pirarubicin, epirubicin and gemcitabine. Through the hydrogen physiological saline, the growth of in-vitro bladder cancer cells can be inhibited significantly, apoptosis of tumor cells is promoted; and in addition, exogenous hydrogen taken through respiration or drinking or injection has good histocompatibility, safety, and few side effects, even if the taken exogenous hydrogen is excessive, the taken exogenous hydrogen can be discharged through respiration without residues.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a composition for treating bladder cancer and the application of hydrogen saline. Background technique [0002] Bladder cancer refers to malignant tumors that occur on the bladder mucosa. It is the most common malignant tumor in the urinary system and one of the ten most common tumors in the whole body. Bladder cancer can occur at any age, even in children. The incidence rate increases with age, and the highest incidence age is 50-70 years old. The incidence rate of bladder cancer in men is 3-4 times that of women. The pathological types of bladder cancer in the histological classification of tumors of the urinary tract system in WHO "Pathology and Genetics of Tumors of the Urinary System and Male Genital Organs" in 2004 include bladder urothelial carcinoma, bladder squamous cell carcinoma, bladder adenocarcinoma, and other rare There are clear cell carcinoma of the bladder, s...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/00A61K33/24A61P35/00A61K31/704A61K31/4745A61K31/7048A61K31/7068
CPCA61K31/4745A61K31/704A61K31/7048A61K31/7068A61K33/00A61K33/24A61P35/00A61K2300/00
Inventor 吴松王飞刘晓岑孙瑞
Owner SHENZHEN LUOHU PEOPLELS HOSPITAL
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