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Instant pyrobixi freeze-drying powdery injection and its production

A technology for pirarubicin and injection, which is applied in the field of instant pirarubicin for injection and its preparation, and can solve the problems of dissolution, slow speed, inconvenient medication and the like

Active Publication Date: 2007-09-05
深圳万乐药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] The currently marketed pirarubicin hydrochloride freeze-dried powder for injection is generally dissolved with water for injection or 5% glucose solution, and cannot be dissolved with normal saline, because when pirarubicin is dissolved with normal saline, the speed is very slow, in It is inconvenient to use medicine clinically

Method used

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  • Instant pyrobixi freeze-drying powdery injection and its production

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Experimental program
Comparison scheme
Effect test

Embodiment 4

[0025] prescription

[0026] The above-mentioned preparation process is adopted.

[0027] Prescription 1

[0028] It can be seen from the test results that when lactose is used as an excipient, the stability of the prescription is much better than that of mannitol, so lactose is better when choosing an excipient.

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Abstract

An instant freeze-dried powder injection of pirarubicin is prepared from pirarubicin, excipient and cosolvent through proportionally dissolving them in the water for injection, aseptic filtering, loading in containers, and freeze-drying.

Description

technical field [0001] The invention relates to an instant pirarubicin for injection and a preparation method thereof. The freeze-dried powder can improve the solubility of pirarubicin in normal saline. Background technique [0002] The currently marketed pirarubicin hydrochloride freeze-dried powder for injection is generally dissolved with water for injection or 5% glucose solution, and cannot be dissolved with normal saline, because when pirarubicin is dissolved with normal saline, the speed is very slow, and in It is very inconvenient to use medicine clinically. [0003] In the Chinese invention patent CN85107562 "Method for Improving the Solubility of an Anthracycline Glycoside Compound in an Injection Solution", it is proposed that for every 10 parts by weight of anthracycline glycoside, add 0.1 to 10 parts by weight of methyl p-hydroxybenzoate Esters can solve the solubility problem of the mentioned anthracycline glycosides in saline, such as doxorubicin, epirubicin...

Claims

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Application Information

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IPC IPC(8): A61K31/704A61K9/19A61K47/26A61K47/14A61K47/16A61K47/20A61P35/00
Inventor 欧阳德方卓秋绮王长平张汉利宝玉荣
Owner 深圳万乐药业有限公司
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