A kind of pirarubicin drug-loaded gelatin submicroemulsion material and its preparation method and application

A technology of pirarubicin gelatin and pirarubicin, which is applied in the direction of pharmaceutical formulations, drug combinations, antineoplastic drugs, etc., to achieve the effects of increasing drug absorption, improving bioavailability, and reducing toxic and side effects

Active Publication Date: 2021-12-17
PINGDINGSHAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] Pirarubicin is a cycline antibiotic with a broad anti-tumor spectrum, so it is widely used in anti-tumor drugs. Its main toxic side effect is cardiotoxicity, which can cause severe myocardial damage and heart failure, and the degree of damage is closely related to the dose. relationship, the main method to reduce its cardiotoxicity is to use drug carriers to change its biodistribution through the carrier, reduce the distribution in the whole body, especially in the heart tissue, and increase its content in local tumors. There is no sustained release drug in the prior art. Anti-tumor pirarubicin drug-loaded gelatin submicroemulsion material was prepared and applied to the preparation of sustained-release anti-tumor drugs

Method used

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  • A kind of pirarubicin drug-loaded gelatin submicroemulsion material and its preparation method and application
  • A kind of pirarubicin drug-loaded gelatin submicroemulsion material and its preparation method and application
  • A kind of pirarubicin drug-loaded gelatin submicroemulsion material and its preparation method and application

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Embodiment 1

[0037] A preparation method of pirarubicin gelatin submicroemulsion material, comprising the steps of:

[0038] (1) Preparation of W / O blank gelatin powder:

[0039] S1. Prepare the aqueous phase: adjust the pH of the acetic acid solution to 5, dissolve 15 mg of gelatin in 1 mL of the acetic acid solution with a volume fraction of 1%, and filter to obtain the aqueous phase material A;

[0040] S2. Preparation of oil phase material B: After mixing paraffin oil and tween80 with a volume ratio of 100:6 evenly, oil phase material B is obtained;

[0041] S3. Preparation of W / O type blank gelatin: add the water phase material A of S1 dropwise to the oil phase material B of S2 according to the volume ratio of 1:4.5, stir and mix for 2.5 hours, and solidify by dropping glutaraldehyde for 4 hours. The sequence of ether, isopropanol aqueous solution and distilled water was repeatedly washed three times and freeze-dried to obtain a W / O type blank gelatin material C;

[0042] Wherein, t...

Embodiment 2

[0048] A preparation method of pirarubicin gelatin submicroemulsion material, comprising the steps of:

[0049] (1) Preparation of W / O blank gelatin powder:

[0050] S1. Prepare the water phase: adjust the pH of the acetic acid solution to 5.5, dissolve 20 mg of gelatin in 1 mL of the acetic acid solution with a volume fraction of 1%, and filter to obtain the water phase material A;

[0051] S2. Preparation of oil phase material B: After uniformly mixing paraffin oil and tween80 with a volume ratio of 100:5, oil phase material B is obtained;

[0052]S3. Preparation of W / O blank gelatin: Add the water phase material A of S1 dropwise to the oil phase material B of S2 at a volume ratio of 1:5, stir and mix for 2 hours, and solidify by adding glutaraldehyde dropwise for 4.5 hours. The sequence of ether, isopropanol aqueous solution and distilled water was repeatedly washed 4 times and freeze-dried to obtain W / O blank gelatin material C;

[0053] Wherein, the ratio of the total v...

Embodiment 3

[0059] A preparation method of pirarubicin gelatin submicroemulsion material, comprising the steps of:

[0060] (1) Preparation of W / O blank gelatin powder:

[0061] S1. Prepare the water phase: adjust the pH of the acetic acid solution to 6, dissolve 25 mg of gelatin in 1 mL of the acetic acid solution with a volume fraction of 1%, and filter to obtain the water phase material A;

[0062] S2. Preparation of oil phase material B: After uniformly mixing paraffin oil and tween80 with a volume ratio of 100:4, oil phase material B is obtained;

[0063] S3. Preparation of W / O blank gelatin: add the water phase material A of S1 dropwise to the oil phase material B of S2 at a volume ratio of 1:5.5, stir and mix for 1.5 hours, and solidify by dropping glutaraldehyde for 5 hours. The sequence of ether, isopropanol aqueous solution and distilled water was repeatedly washed 5 times and freeze-dried to obtain W / O type blank gelatin material C;

[0064] Wherein, the ratio of the total vo...

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Abstract

The present invention relates to the technical field of slow-release medicine preparation, specifically a pirarubicin drug-loaded gelatin submicroemulsion material and its preparation method and application. The present invention firstly prepares the gelatin water phase material A, and then mixes it with the oil phase Material B was blended to prepare W / O type blank gelatin material C, and pirarubicin was coated by using W / O type blank gelatin material C; pirarubicin was combined with W / O type blank gelatin material The compatibility of C is poor, so before coating, pirarubicin is dissolved in a glucose solution with a volume fraction of 5%, and under the action of glucose solution, pirarubicin is coated with W / O type Blank gelatin material C, and then obtain the structurally stable pirarubicin gelatin drug-loaded submicron emulsion material. The invention not only prepares a pirarubicin gelatin drug-loaded submicron emulsion material, but also the pirarubicin gelatin drug-loaded submicron emulsion material can be applied to the preparation of slow-release antitumor drugs.

Description

technical field [0001] The invention relates to the technical field of slow-release medicine preparation, in particular to a pirarubicin drug-loaded gelatin submicroemulsion material and a preparation method and application thereof. Background technique [0002] Cancer has seriously endangered human health and has become one of human killers, ranking first among the common causes of death. Primary liver cancer is one of the common malignant tumors, and its morbidity and mortality are high. According to statistics, the annual incidence of liver cancer in the world ranks fifth in the incidence of malignant tumors, and its mortality rate ranks third, while my country is According to statistics, 55% of liver cancer occurs in my country, with high morbidity and mortality, rapid progression and poor quality of life. In the advanced stage, the surgical resection rate is low, and it is not sensitive to systemic chemotherapy and radiotherapy, and systemic chemotherapy has disadvantage...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/107A61K47/36A61K47/26A61K31/7048A61P35/00
CPCA61K9/1075A61K47/36A61K47/26A61K31/7048A61P35/00
Inventor 杜会强杜迎吴青坡
Owner PINGDINGSHAN UNIVERSITY
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