A kind of pirarubicin drug-loaded gelatin submicroemulsion material and its preparation method and application

A technology of pirarubicin gelatin and pirarubicin, which is applied in the direction of pharmaceutical formulations, drug combinations, antineoplastic drugs, etc., to achieve the effects of increasing drug absorption, improving bioavailability, and reducing toxic and side effects
CN112754993BActive Publication Date: 2021-12-17PINGDINGSHAN UNIVERSITY
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
PINGDINGSHAN UNIVERSITY
Publication Date
2021-12-17

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Abstract

The present invention relates to the technical field of slow-release medicine preparation, specifically a pirarubicin drug-loaded gelatin submicroemulsion material and its preparation method and application. The present invention firstly prepares the gelatin water phase material A, and then mixes it with the oil phase Material B was blended to prepare W / O type blank gelatin material C, and pirarubicin was coated by using W / O type blank gelatin material C; pirarubicin was combined with W / O type blank gelatin material The compatibility of C is poor, so before coating, pirarubicin is dissolved in a glucose solution with a volume fraction of 5%, and under the action of glucose solution, pirarubicin is coated with W / O type Blank gelatin material C, and then obtain the structurally stable pirarubicin gelatin drug-loaded submicron emulsion material. The invention not only prepares a pirarubicin gelatin drug-loaded submicron emulsion material, but also the pirarubicin gelatin drug-loaded submicron emulsion material can be applied to the preparation of slow-release antitumor drugs.
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Description

technical field

[0001] The invention relates to the technical field of slow-release medicine preparation, in particular to a pirarubicin drug-loaded gelatin submicroemulsion material and a preparation method and application thereof. Background technique

[0002] Cancer has seriously endangered human health and has become one of human killers, ranking first among the common causes of death. Primary liver cancer is one of the common malignant tumors, and its morbidity and mortality are high. According to statistics, the annual incidence of liver cancer in the world ranks fifth in the incidence of malignant tumors, and its mortality rate ranks third, while my country is According to statistics, 55% of liver cancer occurs in my country, with high morbidity and mortality, rapid progression and poor quality of life. In the advanced stage, the surgical resection rate is low, and it is not sensitive to systemic chemotherapy and radiotherapy, and systemic chemotherapy has disadvantage...

Claims

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