Ammonia maleate rubicin salt, and its preparing method and use
Patent Information
- Authority / Receiving Office
- CN Β· China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- JIANGSU HANSOH PHARMA CO LTD
- Publication Date
- 2008-06-18
- Estimated Expiration
- Not applicable Β· inactive patent
Smart Images
Figure 1 
Figure 2 
Figure 3
Abstract
Description
technical field
[0001] The invention relates to amrubicin maleate and a preparation method thereof, a pharmaceutical composition containing the compound, and an application of the compound in preparing antitumor drugs and pharmaceutical preparations. Background technique
[0002] Japanese patent JP3-5397 B2 and US patent 4,673,668 disclose the preparation of amrubicin hydrochloride and its use as a drug for cancer chemotherapy. Among them, amrubicin, the target compound specifically synthesized in the examples, was included, and amrubicin hydrochloride was prepared according to conventional methods.
[0003] US Patent No. 6,376,469 also discloses the preparation of crystalline amrubicin hydrochloride with a stable crystal form.
[0004] PCT document WO 9928331 A2 discloses a method for preparing amrubicin hydrochloride crystals by adding hydrochloric acid to a solution of amrubicin and adjusting the pH value.
[0005] Japanese Patent No. JP 1-40493 A and US Patent No. 4,95...