Magnetic pirarubicin nano-drug composite

A pirarubicin and magnetic technology, which is applied in the field of magnetic pirarubicin nano-pharmaceutical composition to treat bladder cancer, can solve problems such as inability to withstand infusion chemotherapy, lack of targeting of chemotherapy drugs, and killing of bladder epithelial cells, and achieve Reduce toxic and side effects, good dispersibility
CN103536626BInactive Publication Date: 2015-05-27代宏 +1
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
代宏
Publication Date
2015-05-27
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention belongs to the field of pharmaceutical preparations, and particularly relates to a magnetic pirarubicin nano-drug composite. The magnetic pirarubicin nano-drug composite comprises pirarubicin, an Fe3O4 nanoparticle and 3-aminopropyl triethoxysilane, wherein the particle diameter of the Fe3O4 nanoparticle is 10-100 nanometers. The magnetic pirarubicin nano-drug composite disclosed by the invention has good stability and dispersity and property of being positioned to a tumour part in a targeted way through an external magnetic field and reduces the toxic side effect on a normal structure by restricting the dual inhibiting effect of THP and Fe3O4 on a cell on a specific tumour part.
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Description

technical field

[0001] The invention belongs to the field of pharmaceutical preparations, and in particular relates to a magnetic pirarubicin nanometer pharmaceutical composition and its application for treating bladder cancer. Background technique

[0002] Bladder cancer is the malignant overgrowth of cells in the bladder that develops into a malignant tumor. Worldwide, bladder cancer is the seventh most common cancer in men, causing 112,300 deaths per year. In contrast, female patients are slightly less than male patients. Bladder cancer is the most common malignant tumor of the urinary system, 90% of which are transitional cell carcinomas, about 5% are phosphorous cell carcinomas, and 2% are adenocarcinomas.

[0003] Currently, the most common treatments for bladder cancer are radical cystectomy and radiotherapy. But this treatment can cause irreversible damage to the patient, resulting in loss of organs, loss of sexual function, damage to normal tissues, etc. Therefo...

Claims

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