43results about How to "Stable intercalation" patented technology

The application provides a medicine containing vincristine, its preparation method, pharmaceutical composition and application. The drug includes nucleic acid nanoparticles and vincristine, and vincristine is mounted on the nucleic acid nanoparticles; the nucleic acid nanoparticles include a nucleic acid domain, the nucleic acid domain includes a sequence, b sequence and c sequence, and the a sequence includes an a1 sequence or The a1 sequence has at least one base insertion, deletion or substitution, the b sequence contains the b1 sequence or the b1 sequence has at least one base insertion, deletion or substitution, and the c sequence contains the c1 sequence or the c1 sequence has at least one base insertion , missing or substituted sequences. The drug containing vincristine provided by the present application, after the nucleic acid structure domain is modified by the target head, can have better targeting, can stably deliver vincristine, and has high reliability.

The application provides a medicine containing gemcitabine, its preparation method, pharmaceutical composition and application. The drug includes nucleic acid nanoparticles and gemcitabine, and gemcitabine is mounted on the nucleic acid nanoparticles; the nucleic acid nanoparticles include a nucleic acid domain, the nucleic acid domain includes a sequence, b sequence and c sequence, and the a sequence includes a1 sequence or a1 sequence occurs at least A sequence of base insertion, deletion or substitution, b sequence contains b1 sequence or b1 sequence has at least one base insertion, deletion or substitution, c sequence contains c1 sequence or c1 sequence has at least one base insertion, deletion or substitution the sequence of. The gemcitabine-containing medicine provided by the present application, after the nucleic acid domain is modified by the target head, can have better targeting, can deliver gemcitabine stably, and has high reliability.

The present application provides a cisplatin-containing medicine, its preparation method, pharmaceutical composition and application. The drug includes nucleic acid nanoparticles and cisplatin, and the cisplatin is mounted on the nucleic acid nanoparticles; the nucleic acid nanoparticles include a nucleic acid domain, the nucleic acid domain includes a sequence, b sequence and c sequence, and the a sequence includes a1 sequence or a1 sequence The sequence with at least one base insertion, deletion or substitution, the b sequence contains the b1 sequence or the b1 sequence has at least one base insertion, deletion or substitution, the c sequence contains the c1 sequence or the c1 sequence has at least one base insertion, deletion or a sequence of substitutions. The cisplatin-containing drug provided by the present application, after its nucleic acid domain is modified by the target head, can have better targeting, can deliver cisplatin stably, and has high reliability.

The present application provides a medicine containing epirubicin, its preparation method, pharmaceutical composition and application. The drug includes nucleic acid nanoparticles and epirubicin, and epirubicin is mounted on the nucleic acid nanoparticles; the nucleic acid nanoparticles include a nucleic acid domain, the nucleic acid domain includes a sequence, b sequence and c sequence, and the a sequence includes a1 The sequence or a1 sequence has at least one base insertion, deletion or substitution sequence, the b sequence contains the b1 sequence or the b1 sequence has at least one base insertion, deletion or substitution, and the c sequence contains the c1 sequence or the c1 sequence has at least one base substitution. Sequences of insertions, deletions or substitutions. The epirubicin-containing medicine provided by the present application can have good targeting ability after the nucleic acid domain is modified by the target head, can deliver epirubicin stably, and has high reliability.

The invention provides a drug containing doxorubicin and a preparation method. The drug includes nucleic acid nanoparticles and doxorubicin, and the doxorubicin is mounted on the nucleic acid nanoparticles; the nucleic acid nanoparticles include a nucleic acid domain, the nucleic acid domain includes a sequence, b sequence and c sequence, and the a sequence includes a1 sequence or A1 sequence contains at least one base insertion, deletion or substitution sequence, b sequence contains b1 sequence or b1 sequence contains at least one base insertion, deletion or substitution sequence, c sequence contains c1 sequence or c1 sequence contains at least one base insertion , deleted or substituted sequences. The drug containing doxorubicin provided by the present invention has good targeting ability after the nucleic acid domain is modified by the target head, can deliver doxorubicin stably, and has high reliability.

The application provides a daunorubicin-containing medicine, its preparation method, pharmaceutical composition and application. The drug includes nucleic acid nanoparticles and daunorubicin, and the daunorubicin is mounted on the nucleic acid nanoparticles; the nucleic acid nanoparticles include a nucleic acid domain, the nucleic acid domain includes a sequence, b sequence and c sequence, and the a sequence includes a1 The sequence or a1 sequence has at least one base insertion, deletion or substitution sequence, the b sequence contains the b1 sequence or the b1 sequence has at least one base insertion, deletion or substitution, and the c sequence contains the c1 sequence or the c1 sequence has at least one base substitution. Sequences of insertions, deletions or substitutions. The daunorubicin-containing drug provided by the present application, after the nucleic acid domain is modified by the target head, can have better targeting, can deliver daunorubicin stably, and has high reliability.

The application provides a drug containing docetaxel, its preparation method, pharmaceutical composition and application. The drug includes nucleic acid nanoparticles and docetaxel, and the docetaxel is mounted on the nucleic acid nanoparticles; the nucleic acid nanoparticles include a nucleic acid domain, the nucleic acid domain includes a sequence, b sequence and c sequence, and the a sequence includes a1 The sequence or a1 sequence has at least one base insertion, deletion or substitution sequence, the b sequence contains the b1 sequence or the b1 sequence has at least one base insertion, deletion or substitution, and the c sequence contains the c1 sequence or the c1 sequence has at least one base substitution. Sequences of insertions, deletions or substitutions. The drug containing docetaxel provided by the present application, after the nucleic acid domain is modified by the target head, can have better targeting, can deliver docetaxel stably, and has high reliability.

The invention discloses a spliced type outdoor display screen structurally comprising a protection plate, a controller, a rotating rod, gap rotating teeth, an adjusting device, an elastic rod, displayscreen bodies, a frame body and a supporting rod; after the improvement, when the spliced type outdoor display screen is used, the display screen bodies are buckled on a positioning frame in parallel; supporting push blocks are connected to the rear portions of the display screen bodies, and adsorption strips can be mounted on the display screen bodies due to the acting force of the supporting push blocks; suckers can firmly adsorb the display screen bodies without loosening due to the strong adsorption force of bionic octopus, so the display screen bodies can be stably mounted on the positioning frame, and the use stability of the display screen bodies is improved. The position of a swing rod is adjusted left and right on a dial through a rotating shaft, after the swing rod is adjusted to a certain position on a sliding rail, the inner wall of a buckle is matched with an elastic buckle, the elastic buckle is fixedly clamped on a lock catch, the flatness, perpendicularity and levelness of spliced display screen bodies are located on the same plane, and the display effect of the display screen is improved.

The application provides a medicine containing methotrexate, its preparation method, pharmaceutical composition and application. The drug includes nucleic acid nanoparticles and methotrexate, and the methotrexate is mounted on the nucleic acid nanoparticles; the nucleic acid nanoparticles include a nucleic acid domain, the nucleic acid domain includes a sequence, b sequence and c sequence, and the a sequence includes a1 sequence or a1 sequence with at least one base insertion, deletion or substitution, b sequence contains b1 sequence or b1 sequence with at least one base insertion, deletion or substitution, c sequence contains c1 sequence or c1 sequence with at least one base sequences of insertions, deletions, or substitutions. The drug containing methotrexate provided by the present application, after the nucleic acid structure domain is modified by the target head, can have better targeting, can deliver methotrexate stably, and has high reliability.

The application provides a medicine containing pentafluorouracil, its preparation method, pharmaceutical composition and application. The drug includes nucleic acid nanoparticles and pentafluorouracil, and pentafluorouracil is mounted on the nucleic acid nanoparticles; the nucleic acid nanoparticles include a nucleic acid domain, the nucleic acid domain includes a sequence, b sequence and c sequence, and the a sequence includes a1 sequence or a1 sequence The sequence with at least one base insertion, deletion or substitution, the b sequence contains the b1 sequence or the b1 sequence has at least one base insertion, deletion or substitution, the c sequence contains the c1 sequence or the c1 sequence has at least one base insertion, deletion or a sequence of substitutions. The pentafluorouracil-containing medicine provided by the present application can have better targeting ability after the nucleic acid domain is modified by the target head, can deliver pentafluorouracil stably, and has high reliability.