Medicine containing idarubicin, its preparation method, pharmaceutical composition and its application

A technology of idarubicin and drugs, which is applied in the field of drugs containing idarubicin, can solve the limited clinical application of small molecule drug idarubicin delivery reliability, the contradiction between toxicity and transfection activity, and the difficulty of connection Non-toxic degradation and other issues, to achieve high reliability, improve stability, and reduce the chance of contact
CN111053919BActive Publication Date: 2022-07-22BAI YAO ZHI DA BEIJING NANOBIO TECH CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
BAI YAO ZHI DA BEIJING NANOBIO TECH CO LTD
Publication Date
2022-07-22

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Abstract

The application provides a medicine containing idarubicin, its preparation method, pharmaceutical composition and application. The drug includes nucleic acid nanoparticles and idarubicin, and idarubicin is mounted on the nucleic acid nanoparticles; the nucleic acid nanoparticles include a nucleic acid domain, the nucleic acid domain includes a sequence, b sequence and c sequence, and the a sequence includes a1 The sequence or a1 sequence has at least one base insertion, deletion or substitution sequence, the b sequence contains the b1 sequence or the b1 sequence has at least one base insertion, deletion or substitution, and the c sequence contains the c1 sequence or the c1 sequence has at least one base substitution. Sequences of insertions, deletions or substitutions. The idarubicin-containing medicine provided by the present application, after the nucleic acid domain is modified by the target head, can have better targeting, can deliver idarubicin stably, and has high reliability.
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Description

technical field

[0001] The present application relates to the field of medicine, in particular, to a medicine containing idarubicin, its preparation method, pharmaceutical composition and application. Background technique

[0002] Idarubicin (Molecular formula: C 26 H 27 NO 9 , molecular weight: 497.49) is an anthracycline cell cycle non-specific anticancer drug, which can inhibit DNA synthesis, interfere with RNA polymerase, and inhibit topoisomerase II. Its potency intensity is stronger than that of daunorubicin and doxorubicin. Mainly used for the treatment of acute non-lymphocytic leukemia, advanced breast cancer, but also for the treatment of myelodysplastic syndrome and non-Hodgkin's lymphoma.

[0003] Currently, anti-tumor antibiotics, including idarubicin, must be administered in large doses of chemotherapeutic drugs in order to achieve effective therapeutic levels at the tumor site, but systemic administration of large doses may damage healthy normal cells and c...

Claims

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