Medicine containing methotrexate, its preparation method, pharmaceutical composition and application thereof

A methotrexate and drug technology, applied in the field of medicine, can solve the problems of limited clinical application of the delivery reliability of small molecule drug methotrexate, contradiction between toxicity and transfection activity in its own design, difficult connection and non-toxic degradation, etc. Achieve high reliability, improve stability, and reduce the chance of contact
CN110960683BActive Publication Date: 2022-05-20BAI YAO ZHI DA BEIJING NANOBIO TECH CO LTD
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Patent Information

Authority / Receiving Office
CN ยท China
Patent Type
Patents(China)
Current Assignee / Owner
BAI YAO ZHI DA BEIJING NANOBIO TECH CO LTD
Publication Date
2022-05-20

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Abstract

The application provides a medicine containing methotrexate, its preparation method, pharmaceutical composition and application. The drug includes nucleic acid nanoparticles and methotrexate, and the methotrexate is mounted on the nucleic acid nanoparticles; the nucleic acid nanoparticles include a nucleic acid domain, the nucleic acid domain includes a sequence, b sequence and c sequence, and the a sequence includes a1 sequence or a1 sequence with at least one base insertion, deletion or substitution, b sequence contains b1 sequence or b1 sequence with at least one base insertion, deletion or substitution, c sequence contains c1 sequence or c1 sequence with at least one base sequences of insertions, deletions, or substitutions. The drug containing methotrexate provided by the present application, after the nucleic acid structure domain is modified by the target head, can have better targeting, can deliver methotrexate stably, and has high reliability.
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Description

technical field

[0001] The application relates to the field of medicine, in particular, to a medicine containing methotrexate, its preparation method, pharmaceutical composition and application. Background technique

[0002] Methotrexate (Methotrexate, CSA: 133073-73-1, molecular formula: C 20 h 22 N 8 o 5 , Molecular weight: 454.45) is an anti-folate anti-tumor drug, mainly through the inhibition of dihydrofolate reductase to hinder the synthesis of tumor cells, and inhibit the growth and reproduction of tumor cells. It is mainly applicable to acute leukemia, breast cancer, choriocarcinoma and malignant mole, head and neck tumors, bone tumors, leukemic meningospinal infiltration, lung cancer, reproductive system tumors, liver cancer, refractory psoriasis vulgaris, systemic lupus erythematosus and Dermatomyositis and other autoimmune diseases.

[0003] Currently, antitumor antibiotics, including methotrexate, must be administered in large doses of chemotherapy drugs in ...

Claims

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