Medicine containing 10-hydroxycamptothecin, its preparation method, pharmaceutical composition and application thereof

A technology of hydroxycamptothecin and drugs, applied in the field of medicine, can solve problems such as impact, toxicity and transfection activity, self-design contradictions, difficulty in ensuring targeting groups, etc.
CN110960684BActive Publication Date: 2022-05-20BAI YAO ZHI DA BEIJING NANOBIO TECH CO LTD
5 Cites 0 Cited by

Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
BAI YAO ZHI DA BEIJING NANOBIO TECH CO LTD
Publication Date
2022-05-20

Smart Images

  • Figure 1
    Figure 1
  • Figure 2
    Figure 2
  • Figure 3
    Figure 3
Patent Text Reader

Abstract

The application provides a medicine containing 10-hydroxycamptothecin, its preparation method, pharmaceutical composition and application. The drug includes nucleic acid nanoparticles and 10-hydroxycamptothecin, and 10-hydroxycamptothecin is mounted on the nucleic acid nanoparticles; the nucleic acid nanoparticles include a nucleic acid domain, and the nucleic acid domain includes a sequence, b sequence and c sequence, The a sequence includes the a1 sequence or the sequence in which at least one base insertion, deletion or substitution occurs in the a1 sequence, the b sequence includes the b1 sequence or the sequence in which at least one base insertion, deletion or substitution occurs in the b1 sequence, and the c sequence includes the c1 sequence or the c1 sequence A sequence in which at least one base has been inserted, deleted or substituted. The drug containing 10-hydroxycamptothecin provided by the present application, after the nucleic acid domain is modified by the target head, can have better targeting, can stably deliver 10-hydroxycamptothecin, and has high reliability.
Need to check novelty before this filing date? Find Prior Art

Description

technical field

[0001] The application relates to the field of medicine, in particular, to a medicine containing 10-hydroxycamptothecin, its preparation method, pharmaceutical composition and application. Background technique

[0002] At present, cancer has become one of the major diseases that threaten human health and quality of life. Finding effective drugs and treatment strategies for cancer treatment has become an urgent problem to be solved in the entire medical field around the world. 10-Hydroxycamptothecin is a commonly used drug in the treatment of liver cancer, gastric cancer, head and neck cancer or leukemia, and plays an important role in medical oncology.

[0003] In order to alleviate the side effects caused by the poor targeting of drug active ingredients, drug delivery carriers have emerged. Their main function is to carry drug active ingredients and transport the active ingredients into blood or tissue cells to treat diseases. At present, there are various ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More