Docetaxel-containing medicine, and preparation method, pharmaceutical composition and application thereof

A docetaxel and drug technology, applied in the field of medicine, can solve the problems of the small molecule drug docetaxel delivery reliability, the limited clinical application of the docetaxel drug, the influence, the toxicity and the self-design contradiction of the transfection activity, etc.
CN111166894AActive Publication Date: 2020-05-19BAI YAO ZHI DA BEIJING NANOBIO TECH CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
BAI YAO ZHI DA BEIJING NANOBIO TECH CO LTD
Publication Date
2020-05-19

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Abstract

The invention provides a docetaxel-containing medicine, and a preparation method, a pharmaceutical composition and application thereof. The medicine comprises nucleic acid nanoparticles and docetaxel,and the docetaxel is mounted on the nucleic acid nanoparticles; the nucleic acid nanoparticles comprise a nucleic acid domain, the nucleic acid domain comprises a sequence a, a sequence b and a sequence c. The sequence a comprises a sequence a1 or a sequence in which at least one base is inserted, deleted or replaced in the sequence a1; the sequence b comprises a sequence b1 or a sequence in which at least one base is inserted, deleted or replaced in the sequence b1; and the sequence c comprises a sequence c1 or a sequence in which at least one base is inserted, deleted or replaced in the sequence c1. After the nucleic acid domain of the docetaxel-containing medicine is modified by a target head, the docetaxel-containing medicine provided by the invention has relatively good targeting property, can stably deliver the docetaxel, and is very high in reliability.
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Description

technical field

[0001] The application relates to the field of medicine, in particular, to a drug containing docetaxel, its preparation method, pharmaceutical composition and application. Background technique

[0002] Docetaxel (Docetaxel) has the same effect as paclitaxel (PTX). It is an M-phase cycle-specific drug that promotes the polymerization of tubules into stable microtubules and inhibits their aggregation and disintegration, thereby significantly reducing the number of tubules and destroying microtubules. grid. In vitro experiments show that it has cytotoxic effect on various mouse and human tumor cell lines, and its antitumor spectrum is wider than that of PTX.

[0003] At present, in order to achieve an effective therapeutic level in the tumor site, antitumor drugs including docetaxel must use large doses of chemotherapy drugs, but large doses of systemic administration may damage healthy normal cells. Adverse reactions in tissues and organs. These adverse reac...

Claims

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