Medicine containing docetaxel, its preparation method, pharmaceutical composition and application

A docetaxel and drug technology, applied in the field of preparation of docetaxel-containing drugs, can solve the problem of limited clinical application, toxicity and translocation of small molecule drug docetaxel delivery reliability Dyeing activity self-design contradictions, difficult connection and non-toxic degradation and other problems, to achieve high reliability, improve stability, and reduce the chance of contact
CN111166894BActive Publication Date: 2022-07-26BAI YAO ZHI DA BEIJING NANOBIO TECH CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
BAI YAO ZHI DA BEIJING NANOBIO TECH CO LTD
Publication Date
2022-07-26

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Abstract

The application provides a drug containing docetaxel, its preparation method, pharmaceutical composition and application. The drug includes nucleic acid nanoparticles and docetaxel, and the docetaxel is mounted on the nucleic acid nanoparticles; the nucleic acid nanoparticles include a nucleic acid domain, the nucleic acid domain includes a sequence, b sequence and c sequence, and the a sequence includes a1 The sequence or a1 sequence has at least one base insertion, deletion or substitution sequence, the b sequence contains the b1 sequence or the b1 sequence has at least one base insertion, deletion or substitution, and the c sequence contains the c1 sequence or the c1 sequence has at least one base substitution. Sequences of insertions, deletions or substitutions. The drug containing docetaxel provided by the present application, after the nucleic acid domain is modified by the target head, can have better targeting, can deliver docetaxel stably, and has high reliability.
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Description

technical field

[0001] The present application relates to the field of medicine, in particular, to a docetaxel-containing medicine, its preparation method, pharmaceutical composition and application. Background technique

[0002] Docetaxel has the same effect as paclitaxel (PTX) and is a specific drug for the M phase cycle, promoting the polymerization of small tubules into stable microtubules and inhibiting their polymerization, thereby significantly reducing the number of small tubules and destroying microtubules grid. In vitro experiments show that it has cytotoxic effect on a variety of mouse and human tumor cell lines, and its anti-tumor spectrum is wider than that of PTX.

[0003] At present, in order to achieve an effective therapeutic level at the tumor site, anti-tumor anti-drugs including docetaxel must apply large doses of chemotherapy drugs, but systemic administration of large doses may damage healthy normal cells, resulting in a series of Causes adverse react...

Claims

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