Gemcitabine-containing medicine and preparation method thereof, and pharmaceutical composition and application thereof

A technology of gemcitabine and drugs, which is applied in drug combinations, medical preparations containing active ingredients, drug delivery, etc., can solve the problem of the reliability of delivery of small molecule drug gemcitabine, the limited clinical application of gemcitabine drugs, the difficulty of connection, non-toxic degradation, impact, etc. question
CN110960691AActive Publication Date: 2020-04-07BAI YAO ZHI DA BEIJING NANOBIO TECH CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
BAI YAO ZHI DA BEIJING NANOBIO TECH CO LTD
Publication Date
2020-04-07

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Abstract

The application provides a gemcitabine-containing medicine and a preparation method thereof, and a pharmaceutical composition and an application thereof. The medicine comprises nucleic acid nanoparticles and gemcitabine, and besides, the gemcitabine is carried on the nucleic acid nanoparticles; and the nucleic acid nanoparticles comprise a nucleic acid domain, the nucleic acid domain comprises a sequence a, a sequence b and a sequence c, the sequence a comprises a sequence a1 or a sequence of the sequence a1 with at least one base insertion, deletion or substitution, the sequence b comprises asequence b1 or a sequence of the sequence b1 with at least one base insertion, deletion or substitution, and the sequence c comprises a sequence c1 or a sequence of the sequence c1 with at least onebase insertion, deletion or substitution. After the nucleic acid structural domain is modified by a target head, the provided gemcitabine-containing medicine has relatively good targeting property, can stably deliver the gemcitabine and is very high in reliability.
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Description

technical field

[0001] The application relates to the field of medicine, in particular, to a medicine containing gemcitabine, its preparation method, pharmaceutical composition and application. Background technique

[0002] Gemcitabine (Gemcitabine) is a new cytidine nucleoside derivative. Like cytarabine, it is activated by deoxycytosine kinase and metabolized by cytosine nucleoside deaminase after entering the human body. This product is a pyrimidine antineoplastic drug with the same mechanism of action as cytarabine. Its main metabolites are incorporated into DNA in cells and mainly act on the G1 / S phase. But the difference is that in addition to being incorporated into DNA, difluorodeoxycytidine can also inhibit nucleotide reductase, resulting in a decrease in deoxynucleoside triphosphate in cells; another difference from ara-C is that it can inhibit deoxycytidine Pyrimidine deaminase reduces the degradation of intracellular metabolites and has a self-enhancing effect....

Claims

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