Medicine containing aspirin, preparation method of medicine containing aspirin, medicine composition and application

Abstract

The application provides medicine containing aspirin, a preparation method of the medicine containing aspirin, a medicine composition and application. The medicine comprises nucleic acid nanoparticlesand the aspirin, wherein the aspirin is hung and loaded on the nucleic acid nanoparticles; the nucleic acid nanoparticles comprise a nucleic acid structural domain; the nucleic acid structural domaincomprises a sequence a, a sequence b and a sequence c; the sequence a comprises a sequence a1 or a sequence obtained by performing insertion, deletion or substitution of at least one base on the sequence a1; the sequence b comprises a sequence b1 or a sequence obtained by performing insertion, deletion or substitution of at least one base on the sequence b1; and the sequence c comprises a sequence c1 or a sequence obtained by performing insertion, deletion or substitution of at least one base on the sequence c1. The medicine containing aspirin provided by the invention has the advantages thatafter the nucleic acid structural domain is modified by a target head, good targeting performance is realized; the aspirin can be stably delivered; and the reliability is very high.

Description

technical field [0001] The present application relates to the field of medicine, in particular to a medicine containing aspirin, its preparation method, pharmaceutical composition and application. Background technique [0002] Aspirin (Aspirin, acetylsalicylic acid) is a white crystal or crystalline powder, odorless or slightly smelly of acetic acid, slightly soluble in water, easily soluble in ethanol, soluble in ether and chloroform, and its aqueous solution is acidic. Aspirin is a derivative of salicylic acid. After nearly a hundred years of clinical application, it has been proved to be effective in relieving mild or moderate pain, such as toothache, headache, neuralgia, muscle pain and dysmenorrhea. It is also used for fever such as cold and flu. The fever of the disease, the treatment of rheumatic pain, etc. In recent years, it has been found that aspirin has an inhibitory effect on platelet aggregation and can prevent the formation of thrombus. It is clinically used ...

AI Technical Summary

Problems solved by technology

Cationic liposomes have high transfection activity in vivo and in vitro, however, because the positive charge on the surface affects their normal distribution in vivo, at the same time, cationic lipids can cause immunogenicity and inflammatory responses in animal experiments

The development of polycationic gene carriers has been relatively mature. However, it is difficult to ensure that the targeting group is on the surface of the structure in the structural design, and there is a self-design contradiction between toxicity and transfection activity. At the same time, its connection is difficult to achieve non-toxic degradation in vivo.

[0004] Therefore, how to improve the delivery reliability of the existing small molecule drug aspirin is one of the difficulties in solving the current limited clinical application of aspirin.

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