Methotrexate-containing medicine, preparation method, medicinal composition and application thereof

A methotrexate and drug technology, applied in the field of medicine, can solve problems such as the contradiction between toxicity and transfection activity, the difficulty of non-toxic degradation of connection, and the limited clinical application of small molecule drug methotrexate delivery reliability
CN110960683AActive Publication Date: 2020-04-07BAI YAO ZHI DA BEIJING NANOBIO TECH CO LTD
5 Cites 1 Cited by

Patent Information

Authority / Receiving Office
CN ยท China
Patent Type
Applications(China)
Current Assignee / Owner
BAI YAO ZHI DA BEIJING NANOBIO TECH CO LTD
Publication Date
2020-04-07

Smart Images

  • Figure 1
    Figure 1
  • Figure 2
    Figure 2
  • Figure 3
    Figure 3
Patent Text Reader

Abstract

The invention provides a methotrexate-containing medicine, a preparation method, a medicinal composition and application thereof. The medicine comprises nucleic acid nanoparticles and methotrexate, wherein the methotrexate is mounted on the nucleic acid nanoparticles; the nucleic acid nanoparticles comprise nucleic acid structural domains, including a sequences, b sequences and c sequences; each asequence contains an a1 sequence or a sequence having at least one basic group inserted, lost or substituted on the a1 sequence; each b sequence contains a b1 sequence or a sequence having at least one basic group inserted, lost or substituted on the b1 sequence; and each c sequence contains a c1 sequence or a sequence having at least one basic group inserted, lost or substituted on the c1 sequence. After the nucleic acid structural domains are subjected to target head modification, the methotrexate-containing medicine has relatively good target performance, can be used for stably deliveringthe methotrexate and has high reliability.
Need to check novelty before this filing date? Find Prior Art

Description

technical field

[0001] The application relates to the field of medicine, in particular, to a medicine containing methotrexate, its preparation method, pharmaceutical composition and application. Background technique

[0002] Methotrexate (Methotrexate, CSA: 133073-73-1, molecular formula: C 20 h 22 N 8 o 5 , Molecular weight: 454.45) is an anti-folate anti-tumor drug, mainly through the inhibition of dihydrofolate reductase to hinder the synthesis of tumor cells, and inhibit the growth and reproduction of tumor cells. It is mainly applicable to acute leukemia, breast cancer, choriocarcinoma and malignant mole, head and neck tumors, bone tumors, leukemic meningospinal infiltration, lung cancer, reproductive system tumors, liver cancer, refractory psoriasis vulgaris, systemic lupus erythematosus and Dermatomyositis and other autoimmune diseases.

[0003] Currently, antitumor antibiotics, including methotrexate, must be administered in large doses of chemotherapy drugs in ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More