Medicine containing epirubicin, preparation method thereof, pharmaceutical composition and application thereof

A technology of epirubicin and drugs, which is applied in the field of medicine, can solve the problem of the small molecule drug epirubicin delivery reliability, the limited clinical application of epirubicin drugs, the contradiction between toxicity and transfection activity, and the difficulty of connection Poison degradation and other issues, to achieve high reliability, improve stability, and reduce the chance of contact
CN110960690BActive Publication Date: 2022-07-22BAI YAO ZHI DA BEIJING NANOBIO TECH CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
BAI YAO ZHI DA BEIJING NANOBIO TECH CO LTD
Publication Date
2022-07-22

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Abstract

The present application provides a medicine containing epirubicin, its preparation method, pharmaceutical composition and application. The drug includes nucleic acid nanoparticles and epirubicin, and epirubicin is mounted on the nucleic acid nanoparticles; the nucleic acid nanoparticles include a nucleic acid domain, the nucleic acid domain includes a sequence, b sequence and c sequence, and the a sequence includes a1 The sequence or a1 sequence has at least one base insertion, deletion or substitution sequence, the b sequence contains the b1 sequence or the b1 sequence has at least one base insertion, deletion or substitution, and the c sequence contains the c1 sequence or the c1 sequence has at least one base substitution. Sequences of insertions, deletions or substitutions. The epirubicin-containing medicine provided by the present application can have good targeting ability after the nucleic acid domain is modified by the target head, can deliver epirubicin stably, and has high reliability.
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Description

technical field

[0001] The present application relates to the field of medicine, in particular, to a medicine containing epirubicin, its preparation method, pharmaceutical composition and application. Background technique

[0002] Epirubicin (Epirubicin, CSA: 56420-45-2, molecular formula: C 27 H 29 NO 11 .HCI, molecular weight: 580.0) is an anti-tumor antibiotic and an isomer of doxorubicin. Its mechanism of action is to directly intervene between DNA nucleic acid base pairs, interfere with the transcription process, prevent the formation of mRNA, and thereby inhibit DNA , RNA and protein synthesis. It is a cell cycle non-specific drug that is effective against a variety of transplanted tumors, including acute leukemia and malignant lymphoma, breast cancer, bronchial lung cancer, ovarian cancer, Wilms tumor, soft tissue sarcoma, liver cancer (including primary hepatic cell carcinoma and metastatic carcinoma) and a variety of solid tumors such as medullary thyroid carcin...

Claims

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