Cisplatin-containing medicine, preparation method of cisplatin-containing medicine, medicine composition and application of cisplatin-containing medicine

A drug, cisplatin technology, applied in the field of medicine, can solve the problems of impact, reliability of small molecule drug cisplatin delivery, limited clinical application of cisplatin, toxicity and self-design contradiction of transfection activity, etc.
CN111150852AActive Publication Date: 2020-05-15BAI YAO ZHI DA BEIJING NANOBIO TECH CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
BAI YAO ZHI DA BEIJING NANOBIO TECH CO LTD
Publication Date
2020-05-15

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Abstract

The invention provides a cisplatin-containing medicine, a preparation method of the cisplatin-containing medicine, a medicine composition and application. The medicine comprises a nucleic acid nanoparticle and cisplatin mounted on the nucleic acid nanoparticle; and the nucleic acid nanoparticle comprises a nucleic acid structural domain, the nucleic acid structural domain comprises a sequence a, asequence b and a sequence c, the sequence a comprises a sequence a1 or a sequence obtained after insertion, deletion or substitution of at least one base of the sequence a1, the sequence b comprisesa sequence b1 or a sequence obtained after insertion, deletion or substitution of at least one base of the sequence b1, and the sequence c comprises a sequence c1 or a sequence obtained after insertion, deletion or substitution of at least one base of the sequence c1. After target head modification, the nucleic structural domain of the cisplatin-containing medicine has better targeting ability, can stably deliver cisplatin and has high reliability.
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Description

technical field

[0001] The application relates to the field of medicine, in particular, to a cisplatin-containing medicine, its preparation method, pharmaceutical composition and application. Background technique

[0002] Cisplatin (Cisplatin, referred to as DDP, CSA: 15773-27-1, molecular formula: Cl 2 h 4 N 2 PtI, molecular weight: 298.029) is orange or yellow crystalline powder, slightly soluble in water, easily soluble in methylformamide. It can be gradually converted into trans or hydrolyzed in aqueous solution. It is clinically effective for various solid tumors such as ovarian cancer, prostate cancer, testicular cancer, lung cancer, nasopharyngeal cancer, esophageal cancer, malignant lymphoma, head and neck squamous cell carcinoma, thyroid cancer and osteogenic sarcoma.

[0003] Currently, antineoplastic drugs including cisplatin must be administered with high doses of chemotherapy drugs in order to achieve effective therapeutic levels at the tumor site, but syste...

Claims

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