Medicine containing epirubicin, preparation method, medicine composition and application thereof

A technology of epirubicin and drugs, which is applied in the field of medicine, can solve problems such as impact, difficult connection and non-toxic degradation, delivery reliability of small molecule drug epirubicin, limited clinical application of epirubicin drugs, etc.
CN110960690AActive Publication Date: 2020-04-07BAI YAO ZHI DA BEIJING NANOBIO TECH CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
BAI YAO ZHI DA BEIJING NANOBIO TECH CO LTD
Publication Date
2020-04-07

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Abstract

The application provides a medicine containing epirubicin, a preparation method, a medicine composition and application thereof. The medicine comprises nucleic acid nanoparticles and the epirubicin, and the epirubicin is mounted on nucleic acid nanoparticles. Nucleic acid nanoparticles include a nucleic acid domain, and the nucleic acid domain contains a a sequence, a b sequence and a c sequence.The a sequence contains a a1 sequence or a sequence that at least one base insertion, base deletion or base substitution occurs in a1 sequence. The b sequence contains a b1 sequence or a sequence thatat least one base insertion, base deletion or base substitution occurs in b1 sequence. The c sequence contains a c1 sequence or a sequence that at least one base insertion, base deletion or base substitution occurs in c1 sequence. After the nucleic acid domain is modified by the target head, the medicine containing epirubicin provided by the present application has better targeting, can stably delivers epirubicin, and has high reliability.
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Description

technical field

[0001] The application relates to the field of medicine, in particular, to a medicine containing epirubicin, its preparation method, pharmaceutical composition and application. Background technique

[0002] Epirubicin (CSA: 56420-45-2, molecular formula: C 27 h 29 NO 11 .HCI, molecular weight: 580.0) is an anti-tumor antibiotic, which is an isomer of doxorubicin. Its mechanism of action is to directly intercalate between DNA nucleic acid base pairs, interfere with the transcription process, prevent the formation of mRNA, and thus inhibit DNA , RNA and protein synthesis. It is a cell cycle non-specific drug that is effective against a variety of transplanted tumors, including acute leukemia and malignant lymphoma, breast cancer, bronchial lung cancer, ovarian cancer, Wilms tumor, soft tissue sarcoma, liver cancer (including primary liver cancer) cell carcinoma and metastatic carcinoma) and various solid tumors such as medullary thyroid carcinoma.

[0003] ...

Claims

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