Cisplatin-containing medicine, preparation method, pharmaceutical composition and application thereof

A drug, cisplatin technology, applied in the field of medicine, can solve the problems of the small molecule drug cisplatin delivery reliability, the limited clinical application of cisplatin drugs, the contradiction between toxicity and transfection activity, the difficulty of connection and non-toxic degradation, etc., to achieve The effect of high reliability, improved stability, and reduced chance of contact
CN111150852BActive Publication Date: 2022-07-26BAI YAO ZHI DA BEIJING NANOBIO TECH CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
BAI YAO ZHI DA BEIJING NANOBIO TECH CO LTD
Publication Date
2022-07-26

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Abstract

The present application provides a cisplatin-containing medicine, its preparation method, pharmaceutical composition and application. The drug includes nucleic acid nanoparticles and cisplatin, and the cisplatin is mounted on the nucleic acid nanoparticles; the nucleic acid nanoparticles include a nucleic acid domain, the nucleic acid domain includes a sequence, b sequence and c sequence, and the a sequence includes a1 sequence or a1 sequence The sequence with at least one base insertion, deletion or substitution, the b sequence contains the b1 sequence or the b1 sequence has at least one base insertion, deletion or substitution, the c sequence contains the c1 sequence or the c1 sequence has at least one base insertion, deletion or a sequence of substitutions. The cisplatin-containing drug provided by the present application, after its nucleic acid domain is modified by the target head, can have better targeting, can deliver cisplatin stably, and has high reliability.
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Description

technical field

[0001] The present application relates to the field of medicine, in particular, to a cisplatin-containing medicine, its preparation method, pharmaceutical composition and application. Background technique

[0002] Cisplatin (Cisplatin, referred to as DDP, CSA: 15773-27-1, molecular formula: Cl 2 H 4 N 2 PtI, molecular weight: 298.029) is orange-yellow or yellow crystalline powder, slightly soluble in water, easily soluble in methylformamide. It can be gradually converted to trans or hydrolyzed in aqueous solution. It is clinically used in various solid tumors such as ovarian cancer, prostate cancer, testicular cancer, lung cancer, nasopharyngeal cancer, esophageal cancer, malignant lymphoma, head and neck squamous cell carcinoma, thyroid cancer and osteosarcoma.

[0003] Currently, antitumor drugs, including cisplatin, must be administered in large doses of chemotherapeutic drugs in order to achieve effective therapeutic levels at the tumor site. However,...

Claims

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