Drug containing doxorubicin and preparation method thereof

Abstract

The invention provides a drug containing doxorubicin and a preparation method. The drug includes nucleic acid nanoparticles and doxorubicin, and the doxorubicin is mounted on the nucleic acid nanoparticles; the nucleic acid nanoparticles include a nucleic acid domain, the nucleic acid domain includes a sequence, b sequence and c sequence, and the a sequence includes a1 sequence or A1 sequence contains at least one base insertion, deletion or substitution sequence, b sequence contains b1 sequence or b1 sequence contains at least one base insertion, deletion or substitution sequence, c sequence contains c1 sequence or c1 sequence contains at least one base insertion , deleted or substituted sequences. The drug containing doxorubicin provided by the present invention has good targeting ability after the nucleic acid domain is modified by the target head, can deliver doxorubicin stably, and has high reliability.

Description

technical field

[0001] The invention relates to the field of medicine, in particular to a medicine containing doxorubicin and a preparation method thereof. Background technique

[0002] Liver cancer is one of the most common malignant tumors. It refers to malignant tumors that occur in the liver, including primary liver cancer and metastatic liver cancer. People often say liver cancer refers to primary liver cancer. Primary liver cancer is one of the most common malignant tumors in the clinic. Currently, the incidence in my country accounts for more than half of the world's patients, accounting for 55% of the world's liver cancer patients.

[0003] Doxorubicin is an anti-tumor antibiotic, which is easy to penetrate the cell membrane and enter the cell, and then quickly combines with the nucleus, inserts into the DNA molecule, forms a stable complex, inhibits the synthesis of DNA, RNA and protein, and is effective for tumors of various growth cycles. Cells are killed. Since...

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