Medicine containing gemcitabine, its preparation method, pharmaceutical composition and application

A gemcitabine and drug technology, which is applied in drug combination, medical preparations containing active ingredients, drug delivery, etc., can solve the limitation of gemcitabine drug delivery reliability in small molecule drug gemcitabine, the contradiction between toxicity and transfection activity in its own design , difficult to connect, non-toxic degradation and other issues, to achieve high reliability, improve stability, and reduce the chance of contact
CN110960691BActive Publication Date: 2022-07-22BAI YAO ZHI DA BEIJING NANOBIO TECH CO LTD
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Patent Information

Authority / Receiving Office
CN ยท China
Patent Type
Patents(China)
Current Assignee / Owner
BAI YAO ZHI DA BEIJING NANOBIO TECH CO LTD
Publication Date
2022-07-22

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Abstract

The application provides a medicine containing gemcitabine, its preparation method, pharmaceutical composition and application. The drug includes nucleic acid nanoparticles and gemcitabine, and gemcitabine is mounted on the nucleic acid nanoparticles; the nucleic acid nanoparticles include a nucleic acid domain, the nucleic acid domain includes a sequence, b sequence and c sequence, and the a sequence includes a1 sequence or a1 sequence occurs at least A sequence of base insertion, deletion or substitution, b sequence contains b1 sequence or b1 sequence has at least one base insertion, deletion or substitution, c sequence contains c1 sequence or c1 sequence has at least one base insertion, deletion or substitution the sequence of. The gemcitabine-containing medicine provided by the present application, after the nucleic acid domain is modified by the target head, can have better targeting, can deliver gemcitabine stably, and has high reliability.
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Description

technical field

[0001] The present application relates to the field of medicine, in particular, to a medicine containing gemcitabine, its preparation method, pharmaceutical composition and application. Background technique

[0002] Gemcitabine is a new cytosine nucleoside derivative. Like cytarabine, it is activated by deoxycytosine kinase and metabolized by cytosine deaminase after entering the human body. This product is a pyrimidine antitumor drug with the same mechanism of action as cytarabine. Its main metabolite is incorporated into DNA in cells and mainly acts on the G1 / S phase. But the difference is that in addition to being incorporated into DNA, difluorodeoxycytidine can also inhibit nucleotide reductase, resulting in a decrease in intracellular deoxynucleoside triphosphate; another difference from cytarabine is that it can inhibit deoxycytidine Pyrimidine deaminase reduces the degradation of intracellular metabolites and has a self-potentiating effect. Clinical...

Claims

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