Adriamycin-containing medicine and preparation method thereof

A doxorubicin and drug technology, applied in the field of doxorubicin-containing drugs and their preparation, can solve the contradiction between toxicity and transfection activity, the non-nucleic acid drug delivery effect has no valuable reports, and the connection is difficult. Toxic degradation and other issues
CN110711253AActive Publication Date: 2020-01-21BAI YAO ZHI DA BEIJING NANOBIO TECH CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
BAI YAO ZHI DA BEIJING NANOBIO TECH CO LTD
Publication Date
2020-01-21

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Abstract

The invention provides adriamycin-containing medicine and a preparation method thereof. The medicine includes a nucleic acid nanoparticle and adriamycin, and the adriamycin is mounted on the nucleic acid nanoparticle; and the nucleic acid nanoparticle includes a nucleic acid structural domain, the nucleic acid structural domain contains an a sequence, a b sequence and a c sequence, and the a sequence contains an a1 sequence or a sequence of the a1 sequence in which at least one base is inserted, missed or replaced, the b sequence contains a b1 sequence or a sequence of the b sequence in whichat least one base is inserted, missed or replaced, and the c sequence contains a c1 sequence or a sequence of the c sequence in which at least one base is inserted, missed or replaced. According to the adriamycin-containing medicine, after the nucleic acid structural domain is modified by a target, targetability is good, adriamycin can be stably delivered, and reliability is high.
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Description

technical field

[0001] The invention relates to the field of medicines, in particular to a medicine containing doxorubicin and a preparation method thereof. Background technique

[0002] Liver cancer is one of the most common malignant tumors. It refers to malignant tumors that occur in the liver, including primary liver cancer and metastatic liver cancer. People usually refer to primary liver cancer when they say liver cancer. Primary liver cancer is one of the most common clinical malignant tumors. At present, the number of cases in my country accounts for more than half of the world, accounting for 55% of the global liver cancer patients.

[0003] Doxorubicin is an anti-tumor antibiotic that easily penetrates the cell membrane and enters the cell, then quickly binds to the nucleus, inserts into the DNA molecule, forms a stable complex, inhibits the synthesis of DNA, RNA and protein, and is effective for tumors of various growth cycles Cells are killed. Since the 1970s, ...

Claims

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