380 results about "Adriamycinol" patented technology

The invention discloses an application of nanometer structure lipid carrier administration system in the antineoplastic drug to reverse the multiple-drug tolerance of tumour cell, which comprises the following parts: solid lipid material, liquid lipid material and antineoplastic drug, wherein the rate of the liquid lipid (such as oleic acid) is 0-30wt%; the solid lipid is selected from monoglyceride; the liquid lipid is oleic acid; the antineoplastic drug is Paclitaxel or adriablastina. The invention has highly effective cell uptaking and cytolymph condensing function with packing molecular target in the antineoplastic drug of cell, which avoids P-glucoprotein in the drug tolerant cytolymph from identifying the antineoplastic drug to reduce exclusion.

The invention discloses an Adriacin or adriacin hydrochloride liposome injection and its preparing process, wherein the injection is prepared from Adriacin or adriacin hydrochloride, neutral phosphatide, negative electric charge phosphatide, cholesterin, anti-oxidant, organic acid, alkali, sugar, buffering agent and water for injection through the steps of preparing margin liposome, homogenizing the liposome, preparing Adriacin or adriacin hydrochloride liposome and their suspension, keeping constant volume, degerming, split charging and conserving.

The invention discloses a tumor-targeted magnetic hydrogel nanoscale medicine delivery system, a construction method and application thereof. The tumor-targeted magnetic hydrogel nanoscale medicine delivery system is prepared by the following steps of: grafting a hydrogel with temperature and pH sensitivity onto the surfaces of ferroferric oxide nanoparticles to form a magnetic hydrogel carrier by a photochemical immobilization method, grafting tumor necrosis factor-alpha, interferon-gamma and a targeted molecular ligand, namely folic acid on the surface of the magnetic hydrogel carrier, and absorbing adriamycin. The system can deliver an antitumor medicine to the periphery of tumor cells by utilizing active targeting, the tumor necrosis factor-alpha, the interferon-gamma and a tumor cellsurface receptor are combined and used for inducing the programmed death of the tumor cells, and the antitumor medicine, namely the adriamycin enters the cells along with the carrier and then is released. Through the experiment, the medicine delivery system has a negligible toxic or side effect, and efficiently inhibits the growth of cancer cells through the coaction mechanism of the tumor necrosis factor-alpha, the interferon-gamma and the antitumor medicine, namely the adriamycin inside and outside the tumor cells.

The invention provides camptothecin-adriamycin prodrug. A structural formula of the prodrug is shown as a formula (I), wherein R1 is camptothecin or derivative group thereof, R2 is one of -CH2- or -O-, R3 is one of -CH2- or -O-, X is one of S or -CH2-, and n1 and n2 are numbers of repeated units, and are integers from 0 to 10. The prodrug can be easily wrapped by amphiphilic polymer to form nanoparticles. The nanoparticles are high in drug carrying efficiency and drug carrying capacity and capable of quickly releasing unmodified camptothecin and adriamycin in the presence of glutathione, and the nanoparticles can be effectively taken in by tumor cells to kill the same. The invention further provides a preparation method of the prodrug, a preparation of the prodrug and application of the prodrug in preparing cancer treating drug.

This invention relates to farmiblastina derivatives, shown as formula, wherein: R1=H or OH, R2 and R3= H or C1-4 hydrocarbon, R4=H, C1-40 saturated or unsaturated hydrocarbon or XR5, wherein X=NH or O, R5=C1-40 saturated or unsaturated hydrocarbon, W=O or NH, R6=H, OH, or O(C1-4 hydrocarbon), R7=H or OH. The invention relates to its preparation and use as medicinal active component thereof.

The invention relates to a preparation method of a dual-targeting drug carrier based on a magnetic metal organic framework material, belonging to the technical field of preparation of bio-medicinal functional materials. The preparation method comprises the following steps: firstly, modifying ferroferric oxide to form dopamine-wrapping ferroferric oxide, and preparing the dual-targeting drug carrier based on the magnetic metal organic framework material by taking dopamine-wrapping ferroferric oxide (Fe3O4@PDA) as the matrix material; and carrying out a series of treatment to obtain an adsorbent, and carrying out selective recognition and separation on adriamycin in an aqueous solution by adopting the adsorbent. The dual-targeting drug carrier based on the magnetic metal organic framework material prepared by adopting the method provided by the invention has good heat stability and very large medicine-carrying capacity, has the acid-base effect, and also has the function of controlling medicine release.

The invention relates to the field of synthesis of pharmaceutical chemistry and particularly relates to a specific method for ferroferric oxide, PDA-coated ferroferric oxide, pegylation and final drug-loading and various steps. A preparation method of pegylated polydopamine-coated drug-loaded magnetic nanoparticles specifically comprises the following steps: (1) synthesizing ferroferric oxide by adopting an alkaline coprecipitation method; (2) carrying out auto-polymerization on dopamine under an alkaline condition in the presence of the ferroferric oxide; (3) pegylating PDA-coated magnetic nanoparticles; and (4) carrying anti-cancer drug adriamycin to the magnetic nanoparticles by using hydrophobic interaction. The obtained composite nanodrug delivery system has the advantages of targeting delivery, high drug loading capacity and good biocompatibility.

The invention belongs to the fields of supramolecular polymer polymer chemistry and drop formation control, and particularly relates to supramolecular hydrogel microsphere modified with cyclodextrin water-solubility polymer and adamantine water-solubility polymer and formed by assembling subjective and objective bodies in a liquid drop, and a preparation method and application thereof. The first purpose of the invention is to provide novel supramolecular hydrogel microsphere formed by assembling subjective and objective bodies and a preparation method thereof method, the second purpose of the invention is to adopt liquid drop as a template to realize supramolecular assembly and achieve uniform particle size and controllable dimension of the supramolecular hydrogel microsphere, and the third purpose of the invention is to provide application of the type of supramolecular hydrogel microsphere in adriacin doxorubicin and taxol water-solubility antitumor drug sustained release, so as to achieve the purpose that a drug can keep a high concentration level for a long time.

The invention relates to a pH-sensitive anticancer prodrug and a preparation method as well as application thereof, which belongs to the field of medicine and chemical industry. The technical problem to be solved is to provide the pH-sensitive anticancer prodrug, and the anticancer prodrug has highest solubility when the pH value is between 4 and 6, can nearly not be dissolved when the pH value is less than 3 or more than 7, and almost does not release adriamycin during the circulation due to small solubility particularly when circulating in blood (the pH value is approximately equal to 7.4), thereby having small toxic side effect. The pH-sensitive anticancer prodrug is a conjugate obtained by coupling the adriamycin and pectin with a molecular weight of between 71,000 and 400,000 through a chemical bond. The pH-sensitive anticancer prodrug is obtained by the following steps: a pectin aqueous solution and an adriamycin aqueous solution are added with a dehydrating agent to react under the condition that the pH value is between 6 and 8, and then are dialyzed and condensed.

The invention belongs to the technical field of composite medicine materials as well as a preparation method and application thereof, more particularly discloses a nanoparticle for embedding medicinal Adriamycin. The nanoparticle has a core-shell type structure with an inner core embedded by an outer shell, wherein the inner core is embedded medicinal adriamycin, and the material for the outer shell is silicon dioxide; and the preparation method of the nanoparticle comprises the following steps of: evenly mixing cyclohexane, a surfactant and n-hexylalcohol, adding a sodium fluoride solution into the mixed solution after being evenly mixed to form a reverse-phase microemulsion; adding adriamycin and tetraethoxysilane into the reverse-phase microemulsion, and reacting to obtain a nanoparticle microemulsion system for embedding the adriamycin; adding a silylanization reagent containing functional groups into the microemulsion system, stirring for reacting, adding ethanol and demulsifying, centrifuging and then preparing the nanoparticle for embedding the medicinal adriamycin and modifying the functional groups. The nanoparticle embedding for the adriamycin has good stability, good biocompatibility, long slow-release time, large drug-loading rate, high medicine packaging rate, and the like, and has application prospect in the fields of tumor imaging and treatment.

The present invention provides one kind of adriamycin derivative in the structure as shown. The modified adriamycin derivative, pharmacological experiment shows, has obvious antitumor activity, as well as cytotoxicity lower than that of adriamycin, obvious targeting property, stable quality and high controllability.

The invention discloses a carbon nanometer tube decorated by polyethyleneimine and a compound of plasmid DNA thereof. The plasmid DNA adopted in the invention comprises P53DNA, green fluorescent protein expression (JPC) and unmethylated oligomerization deoxynucleotide plasmid DNA. The carbon nanometer tube decorated by the polyethyleneimine and the compound of the plasmid DNA have the advantages of high transfection efficiency and less toxicity to cells; in particular, when the concentration is 30 g/ml, the transfection efficiency is larger than 90 percent, and the validity of the cells is larger than 80 percent. The carbon nanometer tube decorated by the polyethyleneimine and the compound of the plasmid DNA have wide application prospect during the process of preparing medicaments for remedying genes outside transfecting osteosarcoma cell bodies and in animal bodies; and the carbon nanometer tube decorated by the polyethylene imine/the plasmid DNA/an adriacin nanometer compound also have wide application during the process of preparing medicaments for restraining the growth of tumor.

The invention discloses a preparation method of a photo-thermal and chemotherapeutic precise synergic antitumor temperature-sensitive gold nanocage hydrogel drug carrying system. The preparation method comprises the following steps of: 1) mixing a gold nanocage with a high-temperature ligand, stirring and incubating the mixture and performing centrifugation to obtain a high-temperature ligand-modified gold nanocage, wherein the high-temperature ligand is a chain-like temperature-sensitive polymer containing a disulfide bond, and the phase change temperature of the high-temperature ligand is 39-50 DEG C; 2) dispersing the high-temperature ligand-modified gold nanocage obtained in the step 1) in an ammonium sulfate solution, stirring and centrifugalizing the mixture, dispersing a solid with an aqueous solution of adriamycin, and leaving the mixture to stand in a dark place to obtain a drug-carrying gold nanocage; and 3) mixing the drug-carrying gold nanocage obtained on the step 2) with a low-temperature ligand, and stirring and incubating the mixture and performing centrifugation to obtain the photo-thermal and chemotherapeutic precise synergic antitumor temperature-sensitive gold nanocage hydrogel drug carrying system, wherein the low-temperature ligand is a chain-like temperature-sensitive polymer containing a disulfide bond, and the phase change temperature of the low-temperature ligand is 26-35 DEG C.

The invention discloses a trgeting and slow-release antineoplastic medicine nanoparticle with amphiphilic polyurethane as a carrier and a preparation method thereof. The nanoparticle is of a nucleus-shell structure provided with two shell layers; a hydrophilic section of amphiphilic polyurethane serves as the shell layer, and a hydrophobic section serves as the nucleus; the nucleus covers the medicines; a functional molecule exposes from the surface of the shell layer of the nanoparticle; organo-siloxane can be hydrolyzed to form another shell layer between the hydrophilic section and the hydrophobic section; the medicines include capecitabine, adriamycin and paclitaxel; the functional molecule is folic acid; and organo-siloxane is tetramethoxysilane. The targeting and slow-release antineoplastic medicine nanoparticle with amphiphilic polyurethane as the carrier has the characteristics that degradable polymer materials are used as the medicine release-control preparations, which enables the medicine to act on a specified wound position with the minimum dosage; and the medicine release rate can be optimized to improve the treatment effect as well as reduce the toxic and side effects.

The invention relates to the technical field of medicines. The invention relates to the field of biomimetic drugs, in particular to biomimetic drug-loaded nanoparticles targeting brain tumor and a preparation method and application thereof, and particularly relates to adriamycin-loaded polyglutamic acid biomimetic nanoparticles which target brain tumor cells and is coated by human brain glioma U87cell membranes and a preparation method and application thereof in drugs for treating brain tumor diseases. The preparation method of the biomimetic drug-loaded nanoparticles targeting brain tumor comprises the following steps: preparing adriamycin-loaded polyglutamic acid nanoparticles, and coating the surfaces of the nanoparticles with the human brain glioma U87 cell membranes to form the stable biomimetic drug-loaded nanoparticles. Therefore, higher encapsulation efficiency and better slow release performance are realized, the targeting property of the nano drug delivery system is improved, the biomimetic drug delivery nanoparticles penetrating through the blood-brain barrier can be more effectively gathered in a brain tumor area, and the effect of treating brain tumors by chemotherapeutic drugs is improved.

The invention relates to a method for preparing a dual-function targeting quantum dot lipidosome. The method comprises the following steps: preparing a single quantum dot lipidosome: dissolving phospholipid, cholesterol, methoxy polyethylene glycol-phospholipid complex and NRP-1 ligand polypeptide polyethylene glycol phospholipid complex into chloroform to obtain a uniform lipid membrane, and drying the chloroform by evaporation; dissolving in an ammonium sulfate solution of quantum dots, and oscillating to obtain lipidosome suspension; extruding, and diluting with normal saline to obtain an active targeting lipidosome containing the quantum dots; adding the active targeting lipidosome containing the quantum dots into an adriamycin normal saline solution, and treating in a water bath for 20 minutes at the temperature of 60 DEG C; and diluting with normal saline through a SephadexG-50 gel column, removing free medicaments, and thus obtaining the dual-function targeting quantum dot lipidosome. The lipidosome prepared by the method can be used for marking and treating glioma cells.

The present invention discloses one kind of folic acid receptor mediated targeting chitosan carrier and its preparation process and application. The present invention has folic acid and its derivative as targeting agent, chitosan and its derivative as carrier and chemotherapeutic medicine adriamycin and other synergistic antisense nucleic acid as acting medicine to raise the stability and targeting property of the administration system. Therefore, the nanometer carrier has wide application foreground in treating tumor.

The invention discloses a method for preparing a nanometer system for multi-model diagnosis and treatment integration. The method comprises the following steps: adopting an in-situ growth nanogold modified rare-earth upconversion nanoparticle method to perform ligand exchange modification on oil-soluble upconversion luminescence nanoparticles of citric acid with a core-shell structure to be water-soluble, and performing citric acid ligand modification on the surfaces of the nanoparticles; uniformly growing nanogold particles on the surface through an in-situ crystal growth method so as to obtain in-situ growth nanogold modified upconversion luminescence nanoparticles; and linking polyethylene glycol-adriamycin hydrochloride containing hydrazone bonds and thiol onto the nanogold surface, thereby obtaining the rare-earth upconversion nanometer system. The invention further provides the nanometer system and application thereof. The nanometer system provided by the invention is uniform in size, high in stability and high in biocompatibility, has the effects of chemotherapy and photo-thermal physiotherapy and can be applied to the fields of upconversion fluorescence imaging, magnetic resonance imaging, anti-cancer drug delivery, photo-thermal physiotherapy of cancers and the like.

The invention discloses an acid-responsive nanometer micelle for drug loading, a preparation method and an application thereof. The nano-micelles were self-assembled from hydrophilic segment polyethylene glycol (PEG) and hydrophobic segment pH-sensitive polyaspartyl diisopropylethylenediamine/di-n-butylethylenediamine (PAsp (DIP/DBA)). The nano-micelles can prolong the drug circulation time, aggregate in the tumor site, increase the local drug concentration, and respond to the micro-acid environment of the tumor tissue. As a drug carrier of stimulation response, the nano-micelles can rapidly release the loaded chemotherapeutic drug adriamycin in the tumor site, and play a significant anti-tumor effect. At the same time, the nano-micelles loaded with magnetic resonance contrast agent superparamagnetic iron oxide can be used for tumor magnetic resonance imaging and monitoring drug uptake and aggregation. This method utilizes nano-drug aggregation at tumor site and acid responsiveness ofcarrier to realize rapid drug release to improve tumor therapeutic effect, and endows nano-micellar MRI visualization function, which provides a promising innovative strategy for cancer diagnosis andtreatment, and has broad application prospects.

The invention discloses a stable system for carrying adriamycin albumin lipid and a preparation method thereof. The invention is characterized by combining the adriamycin on albumin lipid vesica through ultrasonic, high pressure isotrope or micro-fluidization technique. The invention has the advantages of both significantly improving the efficacy and stability of adriamycin lipid vesica and raising the entrapment rate of medicine in the lipid vesica.

The invention belongs to the field of biotechnology, and specifically, relates to a tumor-targeting double-drug carrying and delivery system and a preparation method thereof. The tumor-targeting double-drug carrying and delivery system adopts high-molecular materials, polyethylene glycol, a polypeptide, a treatment gene and a chemotherapeutic drug, wherein the polypeptide is utilized as a targeting head and the high-molecular materials are utilized as base high-molecular carriers. The preparation method comprises that the chemotherapeutic drug of adriamycin and the like are inserted into double chains of the treatment gene to form a gene-chemotherapeutic drug compound; and through electrostatic interaction between the gene chemotherapeutic compound and the base high-molecular carriers, the tumor-targeting double-drug carrying and delivery system which simultaneously carries the treatment gene and the chemotherapeutic drug is obtained. The high-molecular materials are novel polypeptide-modified high-molecular materials, are selected by a phage display technology, and can enter into cells by endocytosis, and thus the gene and chemotherapeutic drug intake capability of tumor cells are improved and safety is improved. The polypeptide (T7) as the targeting head has advantages belonging to transferrin, can effectively avoid interferences from endogenous transferrin, has high targeting and treatment efficiency, is easy for preparation, and can be further developed and be utilized for targeting treatment on other tumor tissue.

The invention discloses an adriamycin-wrapped polyethyleneimine-polyethylene glycol-creatine copolymer micelle and a preparation method thereof. The preparation method comprises the following steps: under the action of pyridine, synthesizing a bicarboxyl-polyethylene glycol copolymer; synthesizing an amino-polyethylene glycol-carboxyl copolymer through amino group termination of ethylene diamine; connecting creatine and an amino group to synthesize a creatine-polyethylene alcohol-carboxyl copolymer; reacting the activated creatine-polyethylene glycol-carboxyl with polyethyleneimine to obtain a creatine-polyethylene glycol-polyethyleneimine copolymer; dialyzing to obtain the creatine-polyethylene glycol-polyethyleneimine micelle; connecting the polyethyleneimine and the creatine at the two ends of polyethylene glycol, and forming a vesicle to wrap adriamycin, with the copolymer as a drug carrier. The adriamycin is applied to clinical treatment of malignant tumors, but have relatively serious damage to normal tissues and organs of a body. The creatine is connected at one end of the polyethylene glycol, the adriamycin is wrapped inside the drug carrier, and the polyethyleneimine is connected at the other end of the polyethylene glycol, so that the stability of the adriamycin-wrapped polyethyleneimine-polyethylene glycol-creatine copolymer micelle can be improved.