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Nanometer system for multi-model diagnosis and treatment integration as well as preparation method and application of nanometer system

A multimodal and systematic technology, applied in nanotechnology for materials and surface science, formulations for in vivo experiments, nanotechnology, etc., to achieve the effect of fewer steps, efficient preparation process, and high photothermal conversion efficiency

Active Publication Date: 2017-09-08
SHANGHAI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, a single treatment method cannot meet the current needs of cancer treatment, so the synergistic dual-modal treatment method that combines photothermal physiotherapy and chemotherapy will greatly improve the effect of cancer treatment
However, there is currently no suitable material and technology that can achieve this requirement

Method used

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  • Nanometer system for multi-model diagnosis and treatment integration as well as preparation method and application of nanometer system
  • Nanometer system for multi-model diagnosis and treatment integration as well as preparation method and application of nanometer system
  • Nanometer system for multi-model diagnosis and treatment integration as well as preparation method and application of nanometer system

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] The method for preparing a nanosystem for the integration of multimodal diagnosis and treatment provided in this example is prepared by in-situ growth nano-gold-modified rare earth up-conversion method, which includes the following steps:

[0046] (1) The prepared particle size is 25 to 30nm and the surface is coated with inert NaGdF 4 layer of oil-soluble rare earth erbium-doped up-conversion luminescent nanoparticles;

[0047] (2) Prepare 1.0g of sodium citrate and 30mL of diethylene glycol, mix the sodium citrate and diethylene glycol, raise the temperature to 110°C in argon, and maintain it for 30min;

[0048] (3) Prepare chloroform and toluene raw materials, get 50mg of step (1) and wrap the surface with inert NaGdF 4 The oil-soluble rare earth erbium doped up-conversion luminescent nanoparticles in the layer are added to chloroform and toluene for dispersion and mixing;

[0049] (4) Mix the mixture prepared in step (3) with the mixture prepared in step (2), heat...

Embodiment 2

[0058] The preparation method of a nano system for the integration of multimodal diagnosis and treatment provided in this example is basically the same as that of Example 1, except that it includes the following steps:

[0059] (1) The prepared particle size is 25 to 30nm and the surface is coated with inert NaGdF 4 layer of oil-soluble rare earth thulium doped up-conversion luminescent nanoparticles;

[0060] (2) Prepare 1.0g of sodium citrate and 30mL of diethylene glycol, mix the sodium citrate and diethylene glycol, raise the temperature to 110°C in argon, and maintain it for 30min;

[0061] (3) Prepare chloroform and toluene raw materials, get 50mg of step (1) and wrap the surface with inert NaGdF 4 layer of oil-soluble rare earth thulium doped up-conversion luminescent nanoparticles, adding it to chloroform and toluene for dispersion and mixing;

[0062] (4) Mix the mixture prepared in step (3) with the mixture prepared in step (2), heat up to 130° C. in argon, keep mi...

Embodiment 3

[0071] The preparation method of a nano system for the integration of multimodal diagnosis and treatment provided in this example is basically the same as that of Examples 1 and 2, except that it includes the following steps:

[0072] (1) The prepared particle size is 25 to 30nm and the surface is coated with inert NaGdF 4 layer of oil-soluble rare earth erbium / thulium co-doped up-conversion luminescent nanoparticles;

[0073] (2) Prepare 1.0g of sodium citrate and 30mL of diethylene glycol, mix the sodium citrate and diethylene glycol, raise the temperature to 110°C in argon, and maintain it for 30min;

[0074] (3) Prepare chloroform and toluene raw materials, get 50mg of step (1) and wrap the surface with inert NaGdF 4 The oil-soluble rare earth erbium / thulium co-doped up-conversion luminescent nanoparticles in the layer are added to chloroform and toluene for dispersion and mixing;

[0075] (4) Mix the mixture prepared in step (3) with the mixture prepared in step (2), heat...

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Abstract

The invention discloses a method for preparing a nanometer system for multi-model diagnosis and treatment integration. The method comprises the following steps: adopting an in-situ growth nanogold modified rare-earth upconversion nanoparticle method to perform ligand exchange modification on oil-soluble upconversion luminescence nanoparticles of citric acid with a core-shell structure to be water-soluble, and performing citric acid ligand modification on the surfaces of the nanoparticles; uniformly growing nanogold particles on the surface through an in-situ crystal growth method so as to obtain in-situ growth nanogold modified upconversion luminescence nanoparticles; and linking polyethylene glycol-adriamycin hydrochloride containing hydrazone bonds and thiol onto the nanogold surface, thereby obtaining the rare-earth upconversion nanometer system. The invention further provides the nanometer system and application thereof. The nanometer system provided by the invention is uniform in size, high in stability and high in biocompatibility, has the effects of chemotherapy and photo-thermal physiotherapy and can be applied to the fields of upconversion fluorescence imaging, magnetic resonance imaging, anti-cancer drug delivery, photo-thermal physiotherapy of cancers and the like.

Description

technical field [0001] The invention relates to the technical field of nano-biological materials, in particular to a nano-system for the integration of multimodal diagnosis and treatment and its preparation method and application. Background technique [0002] In recent years, fluorescence imaging has become one of the research hotspots in optical imaging technology, because fluorescence imaging has the advantages of high sensitivity and no damage to cells and biological tissues. Among them, rare earth-doped upconversion luminescent nanomaterials have attracted widespread attention as a new type of fluorescent material, because they are usually excited by low-energy light (usually near-infrared light 980nm, 808nm) and emit high-energy light ( Red light, green light, near-infrared light 800nm), these advantages can eliminate biological background fluorescence interference. Although near-infrared-excited fluorescence imaging has high sensitivity from cells to tissues to small...

Claims

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Application Information

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IPC IPC(8): A61K49/00A61K49/08A61K49/18A61K31/704A61K47/60A61K41/00A61P35/00B82Y30/00B82Y5/00
CPCA61K31/704A61K41/0052A61K49/0002A61K49/0019A61K49/0067A61K49/08A61K49/1824B82Y5/00B82Y30/00
Inventor 孙丽宁施利毅魏若艳李海宏赵磊刘金亮
Owner SHANGHAI UNIV
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