Drug containing daunorubicin, preparation method thereof, pharmaceutical composition and application thereof

A daunorubicin and drug technology, applied in the field of medicine, can solve the problem of the small molecule drug daunorubicin delivery reliability. Problems such as poisoning and degradation, to achieve high reliability, improve stability, and reduce the chance of contact
CN110960689BActive Publication Date: 2022-07-22BAI YAO ZHI DA BEIJING NANOBIO TECH CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
BAI YAO ZHI DA BEIJING NANOBIO TECH CO LTD
Publication Date
2022-07-22

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Abstract

The application provides a daunorubicin-containing medicine, its preparation method, pharmaceutical composition and application. The drug includes nucleic acid nanoparticles and daunorubicin, and the daunorubicin is mounted on the nucleic acid nanoparticles; the nucleic acid nanoparticles include a nucleic acid domain, the nucleic acid domain includes a sequence, b sequence and c sequence, and the a sequence includes a1 The sequence or a1 sequence has at least one base insertion, deletion or substitution sequence, the b sequence contains the b1 sequence or the b1 sequence has at least one base insertion, deletion or substitution, and the c sequence contains the c1 sequence or the c1 sequence has at least one base substitution. Sequences of insertions, deletions or substitutions. The daunorubicin-containing drug provided by the present application, after the nucleic acid domain is modified by the target head, can have better targeting, can deliver daunorubicin stably, and has high reliability.
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Description

technical field

[0001] The present application relates to the field of medicine, in particular, to a daunorubicin-containing medicine, its preparation method, pharmaceutical composition and application. Background technique

[0002] Daunorubicin (Daunorubicin, CSA: 20830-81-3, molecular formula: C 27 H 29 NO 10 , molecular weight: 527.52) is mainly used for acute lymphoblastic or myeloid leukemia resistant to commonly used antineoplastic drugs, but the remission period is short, so it needs to be combined with other drugs. It is orange-red needle crystal, easily soluble in water. Its aqueous solution is quite stable, and its effect is the same as that of doxorubicin. It can inhibit the synthesis of RNA and DNA by intercalating DNA, and has a particularly obvious effect on RNA, selectively acting on purine nucleosides.

[0003] Currently, antitumor antibiotics, including daunorubicin, must be administered in large doses of chemotherapeutic drugs in order to achieve effect...

Claims

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