Instant pyrobixi freeze-drying powdery injection and its production
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- 深圳万乐药业有限公司
- Publication Date
- 2009-04-15
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Figure 1
Abstract
Description
technical field
[0001] The invention relates to an instant pirarubicin for injection and a preparation method thereof. The freeze-dried powder can improve the solubility of pirarubicin in normal saline. Background technique
[0002] The currently marketed pirarubicin hydrochloride freeze-dried powder for injection is generally dissolved with water for injection or 5% glucose solution, and cannot be dissolved with normal saline, because when pirarubicin is dissolved with normal saline, the speed is very slow, and in It is very inconvenient to use medicine clinically.
[0003] In the Chinese invention patent CN85107562 "Method for Improving the Solubility of an Anthracycline Glycoside Compound in an Injection Solution", it is proposed that for every 10 parts by weight of anthracycline glycoside, add 0.1 to 10 parts by weight of methyl p-hydroxybenzoate Esters can solve the solubility problem of the mentioned anthracycline glycosides in saline, such as doxorubicin, epirubicin...