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120 results about "Substituted carboxylic acid" patented technology
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Halohydrin dehalogenases and related polynucleotides
The present invention relates to novel halohydrin dehalogenase polypeptides and the polynucleotides that encode them. These polypeptides are useful in the production of 4-substituted-3-butyric acid derivatives and vicinal cyano, hydroxyl substituted carboxylic acid esters. The invention also provides related vectors, host cells and methods.
Owner:CODEXIS INC
Polyamide polyols and polyurethanes, methods for making and using, and products made therefrom
InactiveUS20080223519A1Polyureas/polyurethane adhesivesOrganic non-macromolecular adhesivePolyolPolyamide
A polyamide diol is prepared by the reaction of a diamine comprising a polymeric diamine and a non-polymeric diamine, dicarboxyic acid, and a hydroxy substituted carboxylic acid. A polyurethane is prepared by the reaction of the polyamide polyol with a diisocyanate.
Owner:ARIZONA CHEM CO
Enzymatic processes for the production of 4-substituted 3-hydroxybutyric acid derivatives and vicinal cyano, hydroxy substituted carboxylic acid esters
The present invention provides methods and compositions for preparing 4-substituted 3-hydroxybutyric acid derivatives by halohydrin dehalogenase-catalyzed conversion of 4-halo-3-hydroxybutyric acid derivatives. The present invention further provides methods and compositions for preparing 4-halo-3-hydroxybutyric acid derivatives by ketoreductase-catalyzed conversion of 4-halo-3-ketobutyric acid derivatives The present invention also provides methods and compositions for preparing vicinal cyano, hydroxyl substituted carboxylic acid esters.
Owner:CODEXIS INC
Alpha substituted carboxylic acids
InactiveUS20050187266A1Lower blood pressureLower blood sugar levelsBiocideOrganic chemistryDyslipidemiaBlood lipids
Alpha substituted carboxylic acids of formula (I): wherein R1 and R2 are as defined in the specification and R3 is wherein Y, Ar1, Ar2, Ar3, R4, R5, R6, R7, R8, R9, R9a, R10, R11, R12, R17, ring A, and p are as defined in the specification; pharmaceutical compositions containing effective amounts of said compounds or their salts are useful for treating PPAR, specifically PPAR α / γ related disorders, such as diabetes, dyslipidemia, obesity and inflammatory disorders.
Owner:AGOURON PHARMA INC +1
Environment-friendly type composite corrosion and scale inhibitor
InactiveCN1919752ACreate pollutionStrong scale resistanceScale removal and water softeningMolybdateSuccinic acid
The invention discloses an environmental-protective composite inhibiting antisludging agent, which comprises the following parts: inhibiting component, antisludging component and deionized water, wherein the inhibiting component is composed of one or more materials in the molybdate, tungstate, borate, organic substituted carboxylic acid or organic heterocyclic compound; the inhibiting component contains one or more materials in the natural macromolecular compound, epoxy succinic acid or acroleic acid ternary copolymer.
Owner:BEIJING HANBOYING ELECTRIC POWER TECH
Alpha substituted carboxylic acids
InactiveUS20050234066A1Lower blood pressureLower blood sugar levelsBiocideOrganic chemistryDyslipidemiaPharmaceutical drug
Alpha substituted carboxylic acids of formula (I): wherein R1 and R2 are as defined in the specification and R3 is wherein Y, Ar1, Ar2, Ar3, R4, R5, R6, R7, R8, R9, R9a, R10, R11, R12, R17, ring A, and p are as defined in the specification; pharmaceutical compositions containing effective amounts of said compounds or their salts are useful for treating PPAR, specifically PPAR α / γ related disorders, such as diabetes, dyslipidemia, obesity and inflammatory disorders.
Owner:AGOURON PHARMA INC
Marine engine lubrication
InactiveUS20120028522A1Easy to handlePropulsion power plantsOutboard propulsion unitsEngineeringFuel oil
Trunk piston marine engine lubrication, when the engine is fueled by heavy fuel oil, is effected by a composition comprising a major amount of an oil of lubricating viscosity containing at least 50 mass % of a basestock containing greater than or equal to 90% saturates and less than or equal to 0.03% sulphur or a mixture thereof, and respective minor amounts of an over-based metal hydrocarbyl-substituted hydroxybenzoate detergent other than such a detergent having a basicity index of less than two and a degree of carbonation of 80% or greater and at least 1 mass % of a hydrocarbyl-substituted carboxylic acid, anhydride, ester or amide thereof. Asphaltene precipitation in the lubricant, caused by the presence of contaminant heavy fuel oil, is prevented or inhibited.
Owner:INFINEUM INT LTD
Epoxy asphalt material for express highway and bridge, and preparation method
ActiveCN1546571AHigh strengthImprove performanceIn situ pavingsBuilding insulationsAsphaltSuccinic anhydride
An epoxy asphalt material for express highway and bridge wherein the mass portion of the composition is, part A, asphalt 50-80 parts, aliphatic diacid or substituted carboxylic acid 10-25 parts, aliphatic acid anhydride 1-20 parts, polyisobutylene succinic anhydride 2-15 parts, epoxy resin 0-30 parts, epoxy resin hardening accelerating agent 0.1-1.0 part. Part B, epoxy resin, the mass ratio of part an and part B is 2-8:1. The invention also discloses the process for preparing the epoxy asphalt material.
Owner:JURONG NINGWU SCI & TECH DEV
Method for making polyolefin nanocomposites
A polyolefin nanocomposite is prepared by melt blending (a) a polyolefin and (b) a smectite clay in the presence of at least one intercalating agent that is a solid at room temperature and is selected from the group consisting of (a) hydroxy-substituted carboxylic acid esters, (b) amides, (c) hydroxy-substituted amides, and (d) oxidized polyolefins, wherein the ratio of the intercalating agent to the clay is at least 1:3, based on the ash content of the clay.
Owner:BASSELL POLIOLEFINE ITAL SRL
Halohydrin dehalogenases and related polynucleotides
The present invention relates to novel halohydrin dehalogenase polypeptides and the polynucleotides that encode them. These polypeptides are useful in the production of 4-substituted-3-butyric acid derivatives and vicinal cyano, hydroxyl substituted carboxylic acid esters. The invention also provides related vectors, host cells and methods.
Owner:CODEXIS INC
Silver-organic conductive ink for printed electronics
The invention relates to a silver-organic conductive ink for printed electronics. The ink is a solution which is formed by dissolving a silver-organic compound in a specific solvent and can be subjected to ink jetting, gravure, silk screening to form conductive patterns. The silver-organic conductive ink comprises 10-60 wt.% of a saturated carboxylic acid silver compound, 5-50 wt.% of an amido compound, 10-85 wt.% of a solvent and 0-10 wt.% of a thickening agent, the saturated carboxylic acid silver compound comprises a linear chain, a branched chain and a hydroxyl, amido and sulfydryl substituted carboxylic acid silver compound, the amido compound is complex with carboxylic acid silver so as to improve dissolubility of the carboxylic acid silver, the amido compound is primary amine and secondary amine, the amido amount is two times of molar weight of silver ions, the solvent is not reacted with the carboxylic acid silver or amine, and the thickening agent is used for adjusting viscosity. The silver-organic conductive ink can be applied to preparation of conductive lines by means of methods of printed electronics and is capable of simplifying existing line preparation processes.
Owner:FUDAN UNIV
Substituted carboxylic acid derivatives
InactiveUS7176204B2BiocideOrganic chemistryPeroxisome proliferator-activated receptorSubstituted carboxylic acid
Novel substituted carboxylic acid derivatives which bind as ligands to human peroxisome proliferator activated receptor (PPAR) to activate the receptor and thereby exhibit potent effects of decreasing neutral fat, cholesterol, and blood sugar; and a processes for preparing the derivatives. Specifically, substituted carboxylic acid derivatives represented by general formula (1), and pharmaceutically acceptable salts and hydrates of the derivatives, and a processes for preparing the derivatives, the salts, or the hydrates
Owner:KYORIN PHARMA CO LTD
Process for producing optically active 2-substituted carboxylic acid
InactiveUS20050245764A1High optical purityHigh chemical purityOrganic compound preparationOrganic chemistry methodsMedicinal chemistrySubstituted carboxylic acid
The present invention relates to a process for efficiently producing an optically active 2-bromocarboylic acid and an optically active 2-sulfonyloxycarboxylic acid, which are important in the production of medicinal compounds and so forth. An optically active 2-sulfonyloxycarboxylic acid ester is subjected to deprotection under acid conditions to obtain an optically active 2-sulfonyloxycarboxylic acid. A metal bromide is caused to act on the acid to brominate it with configuration inversion at position 2 to thereby produce an optically active 2-bromocarboxylic acid. The resultant optically active 2-bromocarboxylic acid is isolated / purified by subjecting it to a step in which the acid is crystallized and separated as a salt with a base. Thus, an optically active 2-bromocarboxylic acid having a high chemical purity and high optical purity can be produced.
Owner:KANEKA CORP
Halohydrin dehalogenases and related polynucleotides
The present invention relates to novel halohydrin dehalogenase polypeptides and the polynucleotides that encode them. These polypeptides are useful in the production of 4-substituted-3-butyric acid derivatives and vicinal cyano, hydroxyl substituted carboxylic acid esters. The invention also provides related vectors, host cells and methods.
Owner:CODEXIS INC
Preparation and utility of substituted carboxylic acid compounds
The present disclosure is directed to modulators of cyclooxygenase (COX) enzymes and pharmaceutically acceptable salts and prodrugs thereof, the chemical synthesis thereof, and the medical use of such compounds for the treatment and / or management of the severity and duration of non-specific pain, tension-type pain, headache, migraine, lower back pain, sciatica, dental pain, muscular pain, pain associated with acute soft tissue injuries, bursitis, tendonitis, lumbago, periarthritis, tennis elbow, sprains, strains, muscular problems associated with sports injuries, muscular problems associated with accidents, period pain, primary dysmenorrhoea, acute sore throat pain, osteoarthritis, rheumatoid arthritis, cancer, any disorder requiring analgesic response, any disorder requiring anti-inflammatory response, any disorder requiring antipyretic response, any conditions mediated by cyclooxygenase, cystic fibrosis, dementia, Alzheimer's disease, and / or conditions mediated by levels of β-amyloid are described.
Owner:AUSPEX PHARMA INC
Enzymatic processes for the production of 4-substituted 3-hydroxybutyric acid derivatives
Owner:CODEXIS INC
Oleanolic acid oxime ester derivate, preparation method and application thereof
The invention discloses an oleanolic acid oxime ester derivate compound, a preparation method and an application thereof. The structural formula of the compound is shown in formula I, and in the formula I, R refers to furyl, pyridyl, 1-menaphthyl, 4-chlorophenoxy methyl or phenyl with 1 to 2 substitutional groups; and the substitutional groups in phenyl with 1 to 2 substitutional groups are halogen (such as fluorine, chlorine, bromine and iodine) or nitryl. The preparation method comprises the following steps: 1) performing the esterification reaction between oleanolic oxime subject to benzylation protection and substituted carboxylic acids to prepare an oxime ester compound; and 2) removing benzylation protection on the oxime ester compound by Pd / C-H2 to prepare the compound in the formula I. The bactericidal activity test result shows that CAU2012-A has a favorable effect of inhibiting growth of sclerotinia scleotiorum, phytophthora melongenae, botrytis cintrea, pyricularia grisea, rhizoctonia solani and cotton fusarium wilt.
Owner:CHINA AGRI UNIV
Compositions comprising at least one hydroxy-substituted carboxylic acid
ActiveUS7635669B2Avoid corrosionPrevent rustOrganic compound preparationLiquid carbonaceous fuelsFluid compositionHydroxy group
Owner:AFTON CHEMICAL
Marine engine lubrication
InactiveUS20120028521A1Propulsion power plantsOutboard propulsion unitsFuel oilAsphaltene precipitation
Trunk piston marine engine lubrication, when the engine is fueled by heavy fuel oil, is effected by a composition comprising a major amount of an oil of lubricating viscosity containing at least 50 mass % of a Group II basestock, and respective minor amounts of an overbased metal hydrocarbyl-substituted hydroxybenzoate detergent other than such a detergent having a basicity index of less than two and a degree of carbonation of 80% or greater and at least 1 mass % of a hydrocarbyl-substituted carboxylic acid, anhydride, ester or amide thereof. Asphaltene precipitation in the lubricant, caused by the presence of contaminant heavy fuel oil, is prevented or inhibited.
Owner:INFINEUM INT LTD
Pretreatment liquid of organic weldable protective agent preparation method
ActiveCN101638785AGood processing effectImprove featuresNon-metallic protective coating applicationBenzimidazole derivativeOxidation resistant
The invention relates to a pretreatment liquid of an organic weldable protective agent preparation method, which is suitable for antioxidant operation of finishing surface processing working procedurein the manufacture process of a printed-circuit board (PCB). The pretreatment liquid is prepared by no less than two benzimidazole derivatives, no less than two substituted carboxylic acid ammonium salts and deionized water, wherein the usage of the benzimidazole derivative is 0.005%-0.25% and the usage of substituted carboxylic acids ammonium salt is 0.05-0.5%. The pretreatment liquid can obviously improve the reaction activity of the copper surface, adjusts the deposition reaction of the follow-up OSP, improves the compactness and hydrophobicity of the final OSP coating; therefore, the pretreatment liquid can obviously increase the anti-oxidation capability of the printed circuit board in the storage process and the high temperature usage condition, meets the excellent weldable requirements of an electronic assembly plant on the printed circuit board.
Owner:GUANGDONG TONESET SCI & TECH
Marine engine lubrication
Trunk piston marine engine lubrication, when the engine is fueled by heavy fuel oil, is effected by a composition comprising a major amount of an oil of lubricating viscosity containing at least 50 mass % of a basestock containing greater than or equal to 90% saturates and less than or equal to 0.03% sulphur or a mixture thereof, and respective minor amounts of an overbased metal hydrocarbyl-substituted hydroxybenzoate detergent other than such a detergent having a basicity index of less than two and a degree of carbonation of 80% or greater and at least 1 mass % of a hydrocarbyl-substituted carboxylic acid, anhydride, ester or amide thereof. Asphaltene precipitation in the lubricant, caused by the presence of contaminant heavy fuel oil, is prevented or inhibited.
Owner:INFINEUM INT LTD
Amide derivative containing alpha-aminoketone structure and preparation method and application thereof
ActiveCN107056747AEasy to manufactureRaw materials are easy to getBiocideOrganic chemistryWater dispersibleStructural formula
The invention discloses an amide derivative containing an alpha-aminoketone structure and a preparation method and application thereof. A structural formula of the amide derivative is shown in the attached figure. The preparation method comprises the following step of using substituted o-aminobenzoic acid and substituted carboxylic acid R3COOH as initial raw materials, and performing a series of reactions, so as to obtain the amide derivative. When the amide derivative is used for preparing an insecticide, the amide derivative containing the alpha-aminoketone structure is dissolved into a thinner, so as to obtain the insecticide; the weight percentage of the amide derivative containing the alpha-aminoketone structure in the insecticide is 0.001 to 99.99%. During specific application, the insecticide is a conventional preparation, such as a water emulsion, a suspension agent, wettable powder and a water dispersible granule.
Owner:HUBEI BIOPESTICIDE ENG RES CENT
Halohydrin dehalogenases and related polynucleotides
Owner:CODEXIS INC
Preparation of chirality-1-t-butyloxycarboryl-3-hydroxy piperidine and method for chirality turning
ActiveCN103864673AReduce total usageSolve the problem that it is not easy to purify and obtain, and it is difficult to industrializeAsymmetric synthesesSulfonyl chlorideTert-Butyloxycarbonyl protecting group
The invention relates to preparation of chirality-1-t-butyloxycarboryl-3-hydroxy piperidine and a method for chirality turning. The preparation mainly comprises the following steps: resolving N-benzyl-3-hydroxy piperidine as a raw material to obtain a (S) or (R)-1-benzyl-3-hydroxy piperidine camphorsulfonic acid salt, performing alkali freedom to obtain (S) or (R)-1-benzyl-3-hydroxy piperidine, performing palladium carbon hydrogenation debenzylation / t-butyloxycarboryl protection to obtain (S) or (R)-1-t-butyloxycarboryl-3-hydroxy piperidine, acylating substituting sulfonyl chloride of (R) or (S)-1-substituting-3-hydroxy piperidine as a raw material to obtain (R) or (S)-1-substituting-3-hydroxy piperidine sulfonate, substituting by using substituting carboxylate to obtain (S) or (R)-1-substituting-3-hydroxy piperidine carboxylic ester, and performing alkaline hydrolysis to obtain (S) or (R)-1-substituting-3-hydroxy piperidine. The synthesis route is gentle in reaction condition, and is applicable to industrial large-scale production.
Owner:ABA CHEM CORP
Preparation method and use of pentadiene ketone compound containing 1,3,4-oxadiazole sulfo-ethyoxyl
The invention discloses a preparation method and biological activity of a pentadiene ketone compound, containing 1,3,4-oxadiazole sulfo-ethyoxyl, with a function of preventing and treating a plant virus disease, namely a compound expressed in a general formula (I) and a preparation method of the compound. According to the method, by using substituted carboxylic acid, hydrazine hydrate, carbon disulfide, acetone, 4-substituted hydroxy benzaldehyde, substituted aromatic aldehyde, 1,2-dibromoethane and the like as raw materials, methanol, ethanol and N,N-dimethylformamide as solvents and potassium carbonate, sodium hydroxide and potassium hydroxide as catalysts, pentadiene ketone compound containing 1,3,4-oxadiazole sulfo-ethyoxyl is prepared through seven-step synthesis. The compounds I3, I4, I6, I11, I13, I14, I16 and I17 have good functions in cucumber mosaic virus, tobacco mosaic virus, southern rice black-streaked dwarf virus and the like. The formula is shown in the specification.
Owner:GUIZHOU UNIV
Enzymatic resolution of an alpha-substituted carboxylic acid or an ester thereof by Carica papaya lipase
InactiveUS20060003428A1Efficiently and economically obtainedHigh purityFermentationThioester synthesisPapaya family
Disclosed herein is a process for enzymatically resolving a mixture of R- and S-enantiomers of an α-substituted carboxylic acid or an ester or thioester thereof, in which a Carica papaya lipase is used as a biocatalyst to effect the resolution as desired.
Owner:NAT CHENG KUNG UNIV
Method for the determination of lipase
InactiveUS6322993B1Improve validityElimination reactionMicrobiological testing/measurementEnzymologyHydrogenTetra
The invention concerns a method and reagent for the determination of lipase in the presence of a colour substrate and at least one N-substituted carboxylic acid amide derivative or a compound of the general formula (I) or (Ia)in which R1 and R2 independently of one another represent hydrogen or a saturated or unsaturated, substituted or unsubstituted hydrocarbon residue with 2 to 24 carbon atoms, Z denotes a saturated or unsaturated, substituted, cyclic or straight-chained hydrocarbon residue with 1 to 10 carbon atoms, X represents an atom or a group of atoms with positive charge and n is a number from 1 to 3. Tetra-sodium-N-(1,2-dicarboxylethyl)-N-alkylsulfosuccinamide or a mixture containing such a compound has proven to be particularly advantageous for the elimination of unspecific reactions in the determination of lipase in a biological sample.
Owner:BOEHRINGER MANNHEIM GMBH
Bifunctional small molecule compound capable of activating enzyme catalytic reaction, and applications thereof
ActiveCN110128364AUnlimited quantityRealize rationalityOrganic chemistryFermentationBiological activationSubstituted carboxylic acid
Owner:QINGDAO INST OF BIOENERGY & BIOPROCESS TECH CHINESE ACADEMY OF SCI
Process for the preparation of alpha-substituted carboxylic acids from the series comprising alpha-hydroxycarboxylic acids and n-substituted-alpha-aminocarboxylic acids
InactiveUS20070095674A1Electrolysis componentsElectrolytic organic reductionKetoneSubstituted carboxylic acid
A process for the preparation of α-substituted carboxylic acids from the series including α-hydroxycarboxylic acids and N-substituted-α-aminocarboxylic acids by cathodic carboxylation with carbon dioxide of a compound corresponding to the general formula R1—C(═X)R2 which is constituted by aldehydes, ketones or N-substituted imines. In the past, that carboxylation has taken place in an undivided electrolytic cell with the use of a sacrificial anode. As described herein, the carboxylation takes place in the absence of a sacrificial anode in an electrolytic cell divided by a separator, at a diamond film cathode. The anode is formed of a material which is stable under electrolytic conditions; in particular, it is a diamond film electrode. The catholyte includes an organic solvent and a conducting salt.
Owner:EVONIK DEGUSSA GMBH
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