7 results about "Substituted carboxylic acid" patented technology

The invention relates to a preparation method of alpha-bromo-carboxylic acid. The method comprises the following steps: under the protection of nitrogen, dissolving a malonic acid substrate, N-bromosuccinimide (NBS) and pyridine in a reaction solvent, and reacting for 1 hour at 50 DEG C under the irradiation of blue light; and separating the crude reaction product through column chromatography or preparative plate chromatography to obtain the target delta-bromo-carboxylic acid compound. The method has the advantages of mild reaction conditions, simple operation, easily available raw materials, low cost, and good functional group compatibility and substrate universality. In the obtained product, due to high reaction activity of bromine atoms, the bromine atoms can be further derived into various alpha-heteroatom substituted carboxylic acids, and the product has application potential in the fields of synthetic chemistry, drug research and development and the like.

The invention discloses a chiral alpha-alkenyl substituted carboxylic ester compound and an asymmetric preparation method thereof, and the chiral alpha-alkenyl substituted carboxylic ester compound is an optically active compound with a structure as shown in the following formula I, and comprises a stereoisomer with the same chemical general formula, in the formula, * represents a chiral carbon atom; ar is an aromatic ring or a substituted aromatic ring; r1, R2, R3, R4 and R5 are respectively and independently selected from hydrogen, halogen, alkyl or alkoxy of C1-10, aryl and trifluoromethyl; r6 is independently selected from H, C1-10 alkyl or alkoxy, aryl or substituted aryl, and a substituent group of the substituted aryl is selected from halogen and C1-10 alkyl. According to the invention, the chiral alpha-alkenyl substituted carboxylic ester compound is accurately and rapidly synthesized with high yield, high stereoselectivity and gram-level scale. The preparation method is simple, and has biomedical practicability and industrial application prospects.

An aqueous seed coating composition includes water and a formulation that includes a polymer component including a particular acrylate copolymer and a particular polyurethane that includes the reaction product of a 2,2-hydroxymethyl-substituted carboxylic acid, a component including active hydrogen atoms, and a diisocyanate. The composition is used to coat seeds such that the coated seeds produce minimal dust when transported and / or utilized.

Provided herein are compositions and methods for cleaning distillation units, parts of a desalination unit, or process unit surfaces, and / or for removing inorganic and organic scaling from such units, comprising mixtures of short chain organic acids; mixtures of substituted carboxylic acids; mixtures of phosphonic acids and / or phosphonates; mixtures of chelating agents; or mixtures of carboxylate copolymers, homopolymers, and / or terpolymers.

Provided herein are compositions and methods for cleaning distillation units, parts of a desalination unit, or process unit surfaces, and / or for removing inorganic and organic scaling from such units, comprising mixtures of short chain organic acids; mixtures of substituted carboxylic acids; mixtures of phosphonic acids and / or phosphonates; mixtures of chelating agents; or mixtures of carboxylate copolymers, homopolymers, and / or terpolymers.

This invention discloses an asymmetric method for synthesizing fluorine-containing chiral quaternary carbon compounds, relating to the field of organic synthesis techniques. The method includes: using a carboxylic acid compound of Formula 1 and isopropanol as starting materials, and under the action of a catalyst, activating reagent, and base, with a fluorinated reagent as the fluorine source, reacting in an organic solvent to obtain an α-fluoro-α-substituted isopropyl carboxylate as shown in Formula 2. Using a carboxylic acid compound and isopropanol as starting materials, and under the action of a specific catalyst, activating reagent, and base, with a fluorinated reagent as the fluorine source, a specific reaction route is used to achieve highly enantioselective construction of α-fluoro-α-substituted carboxylic acid ester structures. This method has advantages such as mild reaction conditions, simple operation steps, and a wide range of applicable substrates, providing a new and effective approach for enriching the methods for constructing fluorine-containing chiral quaternary carbon compounds.