20 results about "Substituted carboxylic acid" patented technology

The invention belongs to the technical field of synthesis of organic compounds, and particularly relates to a benzocrown ether derivative and a synthesis method thereof. According to the invention, carboxylic acid or substituted carboxylic acid as shown in a general formula I, benzocrown ether as shown in a general formula II and substituted terephthalaldehyde as shown in a general formula IV are used as raw materials, and two kinds of benzocrown ether derivatives as shown in a general formula (A) and a general formula (B) are synthesized through Friedel-Crafts acylation reaction, reduction reaction and substitution reaction. The preparation method provided by the invention has the advantages of simple and easily available raw materials, simple post-treatment, high yield, good universality, environmental friendliness and the like. The two benzocrown ether derivatives as shown in the general formula (A) and the general formula (B), which are disclosed by the invention, serve as important organic synthesis intermediates and have great research values in the aspects of ion recognition, material preparation, medicine synthesis and the like.

The present application discloses a chiral dienyl-substituted carboxylate compound and an asymmetric preparation method thereof, wherein the chiral dienyl-substituted carboxylate compound is an optically active compound with the structure shown in the following formula I, including stereoisomers with the same chemical formula: in the formula, * represents a chiral carbon atom; the substituent R is selected from hydrogen, C 1‑10 alkyl or aryl; Ar is an aromatic ring or a substituted aromatic ring; R 1 , R 2 , R 3 , R 4 , R 5 are independently selected from hydrogen, halogen, C 1‑10 alkyl or alkoxy; R 6 is independently selected from C 1‑10 alkyl or aryl; R 7 is independently selected from C 1‑10 alkyl or aryl. The present application applies a chiral isothiourea catalytic electrochemical synthesis system to precisely and quickly synthesize the chiral dienyl-substituted carboxylate compound in a high yield and high stereoselectivity and in a gram-scale. The preparation method of the present application is simple, and has biomedical practicability and industrial application prospect.

Disclosed are methods for polypropylene decomposition. Also disclosed are products obtained from the decomposition polypropylene including carboxylic acids, dicarboxylic acids, nitro-substituted carboxylic acids and dicarboxylic acids; as well as the salts, esters, and anhydrides thereof.

The invention relates to a preparation method of alpha-bromo-carboxylic acid. The method comprises the following steps: under the protection of nitrogen, dissolving a malonic acid substrate, N-bromosuccinimide (NBS) and pyridine in a reaction solvent, and reacting for 1 hour at 50 DEG C under the irradiation of blue light; and separating the crude reaction product through column chromatography or preparative plate chromatography to obtain the target delta-bromo-carboxylic acid compound. The method has the advantages of mild reaction conditions, simple operation, easily available raw materials, low cost, and good functional group compatibility and substrate universality. In the obtained product, due to high reaction activity of bromine atoms, the bromine atoms can be further derived into various alpha-heteroatom substituted carboxylic acids, and the product has application potential in the fields of synthetic chemistry, drug research and development and the like.

The invention belongs to the technical field of biological medicines, and particularly relates to a novel pyrimidine compound containing substituted aniline as well as a preparation method and application of the novel pyrimidine compound. According to the preparation method, ester bonds are introduced through esterification of different substituted carboxylic acid compounds, so that the lipophilicity of the compounds is improved, the bioavailability is enhanced, the compounds A1-A11 are obtained, the compounds A1-A11 are condensed with different acyl chloride amides to form amido bonds, the stability of the compounds and the binding capacity of the compounds with proteins are improved, and the compounds A12-A21 are obtained. Experiments prove that the novel pyrimidine compound containing substituted aniline has remarkable anti-proliferation and anti-migration activity on non-small cell lung cancer cells, can achieve a remarkable effect of resisting proliferation of the non-small cell lung cancer under the condition of lower concentration, can remarkably inhibit migration of tumor cells, and has a better tumor treatment effect.

The invention relates to the technical field of fine chemical engineering, and particularly discloses a preparation method and a catalyst of 2-chloroethanol. Activated carbon provided by the invention has a high specific surface area and a porous structure, can be used as a mass transfer channel to promote diffusion of ethylene glycol and HCl to ZrO2 active sites, and can be used for preparing 2-chloroethanol through an addition reaction between double bonds. Maleic acid is grafted on the composite carrier, a carboxylic acid group passes through hydroxyl of protonated ethylene glycol to form a protonated intermediate, the nucleophilicity of the hydroxyl is reduced in the process, the electron deficiency of hydroxyl oxygen is enhanced, the hydroxyl oxygen is more easily substituted by Cl <->, and the catalytic effect of the catalyst is improved under the combined action of the carboxylic acid group and zirconium oxide; meanwhile, the activated carbon serves as a solid supporting body, so that the catalyst is easily recycled through filtration or centrifugation, the problem that a traditional homogeneous catalyst (such as adipic acid) is difficult to recycle is solved, and in addition, the catalyst provided by the invention still has a good catalytic effect after being recycled and reused.

The invention discloses a chiral alpha-alkenyl substituted carboxylic ester compound and an asymmetric preparation method thereof, and the chiral alpha-alkenyl substituted carboxylic ester compound is an optically active compound with a structure as shown in the following formula I, and comprises a stereoisomer with the same chemical general formula, in the formula, * represents a chiral carbon atom; ar is an aromatic ring or a substituted aromatic ring; r1, R2, R3, R4 and R5 are respectively and independently selected from hydrogen, halogen, alkyl or alkoxy of C1-10, aryl and trifluoromethyl; r6 is independently selected from H, C1-10 alkyl or alkoxy, aryl or substituted aryl, and a substituent group of the substituted aryl is selected from halogen and C1-10 alkyl. According to the invention, the chiral alpha-alkenyl substituted carboxylic ester compound is accurately and rapidly synthesized with high yield, high stereoselectivity and gram-level scale. The preparation method is simple, and has biomedical practicability and industrial application prospects.

Compositions comprising a) a metal detergent and b) an acid comprising at least one hydrocarbyl-substituted carboxylic acid. The metal detergent comprises at least one alkali metal, alkaline earth metal, or combinations thereof. The weight ratio of the metal detergent a) to the acid b) ranges from 50:1 to 1:10, or 25:1 to 1:10, or 10:1 to 1:10, or 5:1 to 1:7, or 2:1 to 1:3. The compositions may be added to industrial coating or lubricant compositions to reduce corrosion of metal components.

Provided is an alpha-iodine-substituted carboxylic acid having excellent stability with respect to heat, light, and the like. The [alpha]-iodine-substituted carboxylic acid according to the present invention is represented by general formula (1) (in the formula, R1 and R2 each independently represent a hydrogen atom, a carboxyl group, an aliphatic group or an aromatic group, and the [alpha]-iodine-substituted carboxylic acid has a water content in the range of 0.1-15.0 mass% and an acid component content in the range of 0.15-3.0 mass%. [Chemical Formula 1]

An aqueous seed coating composition includes water and a formulation that includes a polymer component including a particular acrylate copolymer and a particular polyurethane that includes the reaction product of a 2,2-hydroxymethyl-substituted carboxylic acid, a component including active hydrogen atoms, and a diisocyanate. The composition is used to coat seeds such that the coated seeds produce minimal dust when transported and / or utilized.

Provided herein are compositions and methods for cleaning distillation units, parts of a desalination unit, or process unit surfaces, and / or for removing inorganic and organic scaling from such units, comprising mixtures of short chain organic acids; mixtures of substituted carboxylic acids; mixtures of phosphonic acids and / or phosphonates; mixtures of chelating agents; or mixtures of carboxylate copolymers, homopolymers, and / or terpolymers.

To provide an oil-based corrosion inhibitor.SOLUTION: A composition comprises a) a metal detergent and b) an acid comprising at least one hydrocarbyl-substituted carboxylic acid. The metal detergent comprises at least one alkali metal, alkaline earth metal, or a combination thereof. A weight ratio of the metal detergent a) to the acid b) is in a range of 50:1 to 1:10, or 25:1 to 1:10, or 10:1 to 1:10, or 5:1 to 1:7, or 2:1 to 1:3. The composition may be added to an industrial coating or a lubricant composition and can reduce corrosion of metal components.SELECTED DRAWING: None

The invention provides electronic-grade gamma-substituted carboxylic acid as well as a purification method and application thereof, the purification method of the electronic-grade gamma-substituted carboxylic acid comprises the following steps: dissolving industrial-grade gamma-substituted carboxylic acid solid, then adding alpha-aminobutyric acid, and uniformly mixing to obtain a mixed solution; the mixed solution is purified through cation exchange resin and anion exchange resin, metal ions are removed, and an electronic-grade gamma-substituted carboxylic acid solution is obtained; carrying out multi-stage filtration on the electronic-grade gamma-substituted carboxylic acid solution to remove particulate matters larger than 50nm in the electronic-grade gamma-substituted carboxylic acid solution so as to obtain the electronic-grade gamma-substituted carboxylic acid solution without microparticles; and drying the electronic-grade gamma-substituted carboxylic acid solution without the microparticles to obtain an electronic-grade gamma-substituted carboxylic acid solid. The prepared electronic-grade gamma-substituted carboxylic acid has the advantages of high purity and low metal ion content, and can meet the requirements of semiconductor process raw materials.

The invention discloses a chiral dienyl substituted carboxylic ester compound and an asymmetric preparation method thereof, the chiral dienyl substituted carboxylic ester compound is an optical active compound with a structure as shown in the following formula I, and comprises a stereoisomer with the same chemical general formula: # imgabs0 # in the formula: * represents a chiral carbon atom; the substituent R is selected from hydrogen, C1-10 alkyl or aryl; ar is an aromatic ring or a substituted aromatic ring; r1, R2, R3, R4 and R5 are respectively and independently selected from hydrogen, halogen, C1-10 alkyl or alkoxy; r6 is independently selected from a C1-10 alkyl group or an aryl group; and R7 is independently selected from C1-10 alkyl groups or aryl groups. According to the invention, a chiral isothiourea catalytic electrochemical synthesis system is applied, and the chiral dialkenyl substituted carboxylic ester compound is accurately and rapidly synthesized with high yield, high stereoselectivity and gram-level scale. The preparation method is simple, and has biomedical practicability and industrial application prospects.

There are provided a recombinant polypeptide having an excellent carboxylic acid reducing activity, and a production method of an aliphatic compound using the recombinant polypeptide.A recombinant polypeptide has: (a) an amino acid sequence A having a sequence identity of 60% or higher, 65% or higher, 70% or higher, 75% or higher, 80% or higher, 85% or higher, 88% or higher, 90% or higher, 95% or higher, 97% or higher, 98% or higher, or 99% or higher with an amino acid sequence set forth in SEQ ID NO: 1; (b) a substitution of at least one amino acid at a position corresponding to a substrate-binding site of a polypeptide having an amino acid sequence set forth in SEQ ID NO: 1 in the amino acid sequence A; and (c) a carboxylic acid reducing activity.

Provided herein are compositions and methods for cleaning distillation units, parts of a desalination unit, or process unit surfaces, and / or for removing inorganic and organic scaling from such units, comprising mixtures of short chain organic acids; mixtures of substituted carboxylic acids; mixtures of phosphonic acids and / or phosphonates; mixtures of chelating agents; or mixtures of carboxylate copolymers, homopolymers, and / or terpolymers.

This invention discloses an asymmetric method for synthesizing fluorine-containing chiral quaternary carbon compounds, relating to the field of organic synthesis techniques. The method includes: using a carboxylic acid compound of Formula 1 and isopropanol as starting materials, and under the action of a catalyst, activating reagent, and base, with a fluorinated reagent as the fluorine source, reacting in an organic solvent to obtain an α-fluoro-α-substituted isopropyl carboxylate as shown in Formula 2. Using a carboxylic acid compound and isopropanol as starting materials, and under the action of a specific catalyst, activating reagent, and base, with a fluorinated reagent as the fluorine source, a specific reaction route is used to achieve highly enantioselective construction of α-fluoro-α-substituted carboxylic acid ester structures. This method has advantages such as mild reaction conditions, simple operation steps, and a wide range of applicable substrates, providing a new and effective approach for enriching the methods for constructing fluorine-containing chiral quaternary carbon compounds.

The invention relates to a preparation method of DOTA-PNP, and belongs to the technical field of material synthesis. Cheap cycleanine is used as a starting raw material and reacts with tert-butyl bromoacetate to generate a tri-substituted product, the tri-substituted product is further substituted with ethyl bromoacetate to obtain a tetra-substituted product, ethyl ester is further hydrolyzed to obtain substituted carboxylic acid, the substituted carboxylic acid and p-nitrophenol are condensed, and finally tert-butyl is removed to obtain a target product.

The invention relates to a 7-series aluminum alloy surface cleaning agent, application of the 7-series aluminum alloy surface cleaning agent and a 7-series aluminum alloy surface cleaning method, and adopts the technical scheme that the 7-series aluminum alloy surface cleaning agent comprises 10 parts of hydroxyl substituted carboxylic acid; 2 to 15 parts of a surfactant; 2-10 parts of a metal complexing agent; and 1-10 parts of a corrosion inhibitor. The cleaning agent has the characteristics of high cleaning capacity and low corrosion to the surface of the 7-series aluminum alloy on silicon dioxide left on the surface of the 7-series aluminum alloy due to polishing of a silicon dioxide polishing solution.