Combined Chinese and western medicine sustained-release agent for preventing and treating rabbit coccidiosis and preparation method thereof

A technology of rabbit coccidiosis and a sustained-release agent, which is applied to the field of drug control of livestock and poultry parasites, can solve the problems of slowing down the growth rate of rabbits, affecting the treatment effect, affecting the control effect, etc. Extraction works well

Inactive Publication Date: 2008-11-05
HEZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, at present, most of the anticoccidial Chinese medicines are powdered by pulverization or even fresh or dry products are chopped and fed. The active ingredients of the traditional Chinese medicine are leached slowly. The decoction of traditional Chinese medicine needs to be administered orally. When the rabbit is seriously infected with coccidiosis, the appetite will decrease, and oral administration is difficult. It needs to be fed, and the control effect will be affected. At the same time, the growth rate of the rabbit will be slowed down.

Method used

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  • Combined Chinese and western medicine sustained-release agent for preventing and treating rabbit coccidiosis and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] (1) Weigh 30g Changshan, 40g Qingyu, 30g Sophora flavescens, 20g Pulsatilla, 20g Bupleurum, 20g Imperata rhizome, 1og licorice, mix well, and set aside.

[0031] (2) Mix the medicinal powder in step (1), soak in 90% ethanol, the amount of ethanol added is 15cm above the medicinal surface, and the container is a stainless steel bucket, which needs to be airtight to prevent the ethanol from volatilizing. After 1 day, put it in a traditional Chinese medicine extraction tank, condense and reflux for extraction at 80°C for 2 hours, centrifuge the extract, and distill under reduced pressure to recover ethanol to obtain a black extract for future use.

[0032] (3) Soak the dregs extracted by ethanol in step (2) in distilled water, add water to the extent that the amount of water is 12, put it in a traditional Chinese medicine extraction tank after 1 day, condense and reflux for extraction at 100 ° C for 2 hours, and centrifuge The extract is combined with the extract from step...

Embodiment 2

[0039] In this example, weigh 25g Changshan, 45g Qingyu, 25g Sophora, 25g Pulsatilla, 12g Bupleurum, 25g Imperata Rhizome, 13g Licorice; add ethanol to the surface of 15cm, soak in ethanol for 1 day; soak in water for 1 day Weigh 0.20g of dicrotidine and dissolve it with 2.5mL N, N-dimethyl sulfoxide; the amount of porous starch is 90g; weigh 0.20g of chitosan and dissolve it with 5% acetic acid 3mL; the rest of the preparation methods and processes are the same In Example 1. Finally, every 1g of medicinal powder is equivalent to 0.0012g of 1g of Chinese herbal crude drug and dicloprazole.

Embodiment 3

[0041]In this example, weigh Changshan 32g, Qingyu 38g, Sophora flavescens 33g, Pulsatilla 17g, Bupleurum 17g, Imperata rhizome 18g, Licorice 15g; add ethanol to the surface of 15cm, soak in ethanol for 1 day; soak in water for 1 day Weigh 0.30g of dicrotidine and dissolve it with 3.5mL N, N-dimethyl sulfoxide; the amount of porous starch is 90g; weigh 0.20g of chitosan and dissolve it with 5% acetic acid 3mL; the rest of the preparation methods and processes are the same In Example 1. Finally, every 1g of medicinal powder is equivalent to 0.0018g of 1g of Chinese herbal crude drug and dicloprazole.

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Abstract

The invention discloses a retarder combining Chinese medicines and western medicines and used for preventing and curing the rabbit coccidiosis and a preparation method thereof, pertaining to the technical field of prevention and cure with the drug of poultry and livestock parasite. The retarder comprises ingredients with portions by weight: 2 to 5 portions of antifeverile dichroa root, 3 to 6 portions of abrotanum, 2 to 5 portions of sophora flavescens, 1 to 3 portions of pulsatilla chinensis, 1 to 3 portions of radix bupleuri, 1 to 3 portions of rhizoma imperatae, 1 to 3 portions of liquoric root, 0.01 to 0.05 portions of diclazuril, 8 to 10 portions of porous starch and 0.001 to 0.003 portions of chitosan. The ingredients are prepared by the steps of soaking in ethanol and Soxhlet extraction, followed by soaking in water and Soxhlet extraction, mixing, absorption and combination of extract and diclazuril as well as porous starch and chitosan, and regulation of medicinal powder quality, etc. The results from the experiments show that the egg reduction rate for the rabbit coccidiosis is 99.2 percent; in addition, the retarder of the invention is mainly applied to the prevention and cure of the rabbit coccidiosis.

Description

technical field [0001] The invention belongs to the technical field of poultry parasite drug prevention and control, and relates to a slow-release agent combined with Chinese and Western medicine for preventing and treating rabbit coccidiosis and a preparation method thereof. Background technique [0002] Rabbit coccidiosis is a parasitic disease caused by protozoa, and is one of the most common and serious parasitic diseases in rabbits. It is reported that the infection rate of young rabbits is as high as more than 90%, and the mortality rate is close to 60%. The literature reports more than 16 species of coccidia in rabbits, among which Eimeria stezeri parasitizes in the epithelial cells of the liver and bile ducts, and the rest parasitize in the epithelial cells of the intestinal mucosa. The predisposing factors of this disease are generally intestinal type, liver type and mixed type infection. Up to now, the main means of preventing and controlling coccidiosis in rabbi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/899A61K47/36A61P33/02A61K31/53
Inventor 周民杰梁柏林
Owner HEZHOU UNIV
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