Method for preparing florfenicol microemulsion

A technology of florfenicol and microemulsion, which is applied in the field of preparation of florfenicol microemulsion, can solve the problems of short drug effect maintenance time, low bioavailability, poor drug dispersibility, etc., and achieve remarkable therapeutic effect and safety Good, long half-life effect

Inactive Publication Date: 2008-04-02
杨水新
View PDF0 Cites 10 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Compared with chloramphenicol, florfenicol has no potential bone marrow suppression or adverse reactions causing aplastic anemia, but florfenicol is insoluble in water, and the liquid preparation of florfenicol microemulsion on the market is in order to dissolve Florfenicol has added a large amount of organic solvents, so that the cost is higher, the irritation is large, the adverse pharmacological effects are obvious, and the bioavailability is low; at the same time, there are also poor drug dispersibility, easy to separate out when diluted, and drug effect maintenance. Defects such as short time

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] A kind of Florfenicol microemulsion is made by following method:

[0025] (1). Weigh 5g of Florfenicol, add 5ml of Tween-80, and stir evenly;

[0026] (2). Add 10ml of propylene glycol and stir evenly;

[0027] (3). Add 10ml of DMF and stir evenly;

[0028] (4). Add water to 100ml and stir to form a florfenicol microemulsion solution.

Embodiment 2

[0030] A kind of Florfenicol microemulsion is made by following method:

[0031] (1). Weigh 10g of Florfenicol, add Tween-80 5ml, and stir evenly;

[0032] (2). Add 20ml of propylene glycol and stir evenly;

[0033] (3). Add 20ml of DMF and stir well;

[0034] (4). Add water to 100ml and stir to form a florfenicol microemulsion solution.

Embodiment 3

[0036] A kind of Florfenicol microemulsion is made by following method:

[0037] (1). Weigh 15g of Florfenicol, add 15ml of Tween-80, and stir evenly;

[0038] (2). Add 10ml of propylene glycol and stir evenly;

[0039] (3). Add 10ml of DMF and stir evenly;

[0040] (4). Add water to 100ml and stir to form a florfenicol microemulsion solution.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention relates to the preparation method of a diclazuril micro-emulsion. The preparation procedure of the diclazuril micro-emulsion is as follows: (1) florfenicol is weighed, added with tween-80 and is mixed uniformly; (2) propanediol is added and mixed uniformly; (3) DMF dimethylformamide is added and mixed uniformly; (4) water is added and mixed, and then florfenicol micro-emulsion is prepared. The invention adopts advanced microemulsion technology, and florfenicol which is slightly soluble in water is prepared into florfenicol micro-emulsion solution in any proportion. The preparation method effectively improves the bioavailability of the product, the property of the quality is stationary and the absorption is complete. The drug is released by targeting drug release and the product has the characteristics of rapid, durable and high effects. The half-life is long and the effective plasma concentration is maintained in bodies for a long time. The diclazuril micro-emulsion of the invention has low toxicity, high effects, sound safety, is capable of curing bacterial diseases, is drinkable with water and the use is convenient.

Description

technical field [0001] The invention belongs to the field of microemulsion preparations, in particular to a preparation method of florfenicol microemulsion. Background technique [0002] Florfenicol is a new generation of chloramphenicol-like broad-spectrum antibiotics for animals. It has the characteristics of broad-spectrum antibacterial, oral administration, fast absorption by intramuscular injection, wide distribution in the body, safety and high efficiency, and strong antibacterial activity. Effective treatment of bacterial diseases. Compared with chloramphenicol, florfenicol has no potential bone marrow suppression or adverse reactions causing aplastic anemia, but florfenicol is insoluble in water, and the liquid preparation of florfenicol microemulsion on the market is in order to dissolve Florfenicol has added a large amount of organic solvents, so that the cost is higher, the irritation is large, the adverse pharmacological effects are obvious, and the bioavailabil...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/165A61K9/107A61K47/34A61P31/04A61K47/26
Inventor 杨水新
Owner 杨水新
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap