Method for preparing florfenicol microemulsion

Abstract

The invention relates to the preparation method of a diclazuril micro-emulsion. The preparation procedure of the diclazuril micro-emulsion is as follows: (1) florfenicol is weighed, added with tween-80 and is mixed uniformly; (2) propanediol is added and mixed uniformly; (3) DMF dimethylformamide is added and mixed uniformly; (4) water is added and mixed, and then florfenicol micro-emulsion is prepared. The invention adopts advanced microemulsion technology, and florfenicol which is slightly soluble in water is prepared into florfenicol micro-emulsion solution in any proportion. The preparation method effectively improves the bioavailability of the product, the property of the quality is stationary and the absorption is complete. The drug is released by targeting drug release and the product has the characteristics of rapid, durable and high effects. The half-life is long and the effective plasma concentration is maintained in bodies for a long time. The diclazuril micro-emulsion of the invention has low toxicity, high effects, sound safety, is capable of curing bacterial diseases, is drinkable with water and the use is convenient.

Description

technical field [0001] The invention belongs to the field of microemulsion preparations, in particular to a preparation method of florfenicol microemulsion. Background technique [0002] Florfenicol is a new generation of chloramphenicol-like broad-spectrum antibiotics for animals. It has the characteristics of broad-spectrum antibacterial, oral administration, fast absorption by intramuscular injection, wide distribution in the body, safety and high efficiency, and strong antibacterial activity. Effective treatment of bacterial diseases. Compared with chloramphenicol, florfenicol has no potential bone marrow suppression or adverse reactions causing aplastic anemia, but florfenicol is insoluble in water, and the liquid preparation of florfenicol microemulsion on the market is in order to dissolve Florfenicol has added a large amount of organic solvents, so that the cost is higher, the irritation is large, the adverse pharmacological effects are obvious, and the bioavailabil...

AI Technical Summary

Problems solved by technology

Compared with chloramphenicol, florfenicol has no potential bone marrow suppression or adverse reactions causing aplastic anemia, but florfenicol is insoluble in water, and the liquid preparation of florfenicol microemulsion on the market is in order to dissolve Florfenicol has added a large amount of organic solvents, so that the cost is higher, the irritation is large, the adverse pharmacological effects are obvious, and the bioavailability is low; at the same time, there are also poor drug dispersibility, easy to separate out when diluted, and drug effect maintenance. Defects such as short time