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Preparation method and application of triazine anticoccidial medicinal composite molecularly imprinted polymer

A technology for imprinting polymers and composite molecules, which can be used in chemical instruments and methods, other chemical processes, etc., and can solve the problems of few preparation methods for molecularly imprinted solid-phase extraction columns.

Active Publication Date: 2015-01-07
ANHUI AGRICULTURAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

This patented new type of material called a special chemical substance (SCA) was developed by researchers at Cornell University during World War II when they discovered it's possible to create small particles made from certain types of materials such as silica gel or glasses. These tiny objects are able to bind different kinds of dyes together without being too big. They were found useful because their unique properties could help identify unknown components more easily than other methods based on size alone.

Problems solved by technology

The technical problem addressed by this patented method relates to finding ways to prepare small particles called mimicry beads or microcapsules containing certain types of medications while reducing their harmful effects when used in large amounts without causing any negative side reactions during consumption.

Method used

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  • Preparation method and application of triazine anticoccidial medicinal composite molecularly imprinted polymer
  • Preparation method and application of triazine anticoccidial medicinal composite molecularly imprinted polymer
  • Preparation method and application of triazine anticoccidial medicinal composite molecularly imprinted polymer

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Experimental program
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Effect test

Embodiment 1

[0021] (1) Comparing methanol, acetonitrile, N, N-dimethylamide, tetrahydrofuran respectively, investigating the dissolving effects of different solvents on DIC, TOL and MAA, the results show that DIC and MAA are insoluble in methanol, insoluble in acetonitrile, slightly soluble N,N-dimethylamide and tetrahydrofuran, while TOL is insoluble in water, but soluble in the above four solvents, and is most soluble in tetrahydrofuran. Therefore, tetrahydrofuran can be selected as the primer for the preparation of DIC and TOL composite molecularly imprinted polymers. Pore ​​agent. In this example, 0.204 g of DIC (0.5 mmol) and 0.213 g of TOL (0.5 mmol) were weighed and dissolved in 20 mL of tetrahydrofuran to obtain a tetrahydrofuran solution of composite template molecules.

[0022] (2) Compare the influence of functional monomer MAA and the ratio of template molecule I and II dosage: add functional monomer MAA in the tetrahydrofuran solution of the composite template molecule of ste...

Embodiment 2

[0044] (1) Weigh no more than 0.204g of template molecule I diclazuril (DIC) and no more than 0.213g of template molecule II toltrazuril (TOL) and dissolve them in 20mL of tetrahydrofuran, add 0.336mL of functional monomer Methacrylic acid MAA, ultrasonically oscillating at room temperature for 30 minutes to fully combine template molecules I and II with functional monomers; then add 5.06mL of cross-linking agent PETA; then add 0.123g of azobisisobutyronitrile AIBN, mix well , ultrasonic oscillation for 15min, at N 2 Heat in a 60°C water bath for 16 hours under protection to obtain a white solid polymer;

[0045] (2) Pulverize the white solid polymer in step (1), grind it through a 200-mesh sieve, and elute the template molecules (DIC&TOL) in the polymer with a volume ratio of 6:3:1 acetonitrile / water / acetic acid solution, collect The product was dried in an oven at 60°C to obtain molecularly imprinted polymers (DIC&TOL MIPs) using DIC and TOL as composite templates.

[0046...

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Abstract

The invention discloses a preparation method and application of a triazine anticoccidial medicinal composite molecularly imprinted polymer, and belongs to the technical field of molecular imprinting. The method comprises following steps: preparing a DIC (Diclazuril)-TOL (Toltrazuril) composite molecularly imprinted polymer by taking DIC as a template molecule I, taking TOL as a template molecule II, taking tetrahydrofuran as a pore-foaming agent, taking methacrylic acid (MAA) as a functional monomer, taking pentaerythritol triacrylate (PETA) as a cross-linking agent and taking azodiisobutyronitrile (AIBN) as an initiator; and mixing the imprinted polymer with diatomaceous earth at equal mass to obtain solid-phase extraction column filler which has high recognition capability specific to the DIC and the TOL. Through adoption of the method, the technical problem that a conventional molecular imprinting technology can only be applied to solid-phase extraction column preparation of a single target compound but cannot be applied to separate solid-phase extraction column preparation of various compounds is solved.

Description

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Claims

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Application Information

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Owner ANHUI AGRICULTURAL UNIVERSITY
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