Diclazuril effervescence patch for birds

A technology of diclazuril and effervescent tablets, which is applied in the direction of medical preparations, drug combinations, and pharmaceutical formulas of non-active ingredients, and can solve the problem of not considering the influence of the solubility of diclazuril soluble powder and the absence of diclazuril. Diclazuril’s stability is not considered due to bioavailability, digestion and physiological combination, so as to ensure high dispersibility, improve bioavailability, and high dissolution rate

Inactive Publication Date: 2008-04-02
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this method also changes the solubility of diclazuril by adjusting the pH value, and does not consider the influence of the pH value of the chicken's gastrointestinal tract environment on the solubility of the produced diclazuril soluble powder, nor does it consider Effects of Acidic and Alkaline Solubilizers on the Stability of Diclazuril
[0006] Ma Xiaoping (2004) reported that β-cyclodextrin inclusion method was used to improve the solubility of diclazuril, but whether diclazuril after inclusion can have

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0055] Take 5 grams of diclazuril and 45 grams of polyvinylpyrrolidone and dissolve them in 100 milliliters of dimethylformamide, and heat to dissolve them all. The solution was dried under reduced pressure in a vacuum drying oven to remove dimethylformamide to obtain 50 g of a solid. Put it still in the freezer for 24 hours to make it brittle, and then crush it through a 30-mesh sieve to obtain the soluble powder of diclazuril. With 50 grams of diclazuril soluble powder of gained and 150 grams of citric acid, 100 grams of sodium bicarbonate and 195 grams of soluble starch, use 100 milliliters of ethanol solutions of 5% polyvinylpyrrolidone to moisten and granulate, and cold wind evaporates ethanol to prepare It is made into 500g granules, then granulated, and pressed into 150 tablets with a weight of 3.3 grams.

Embodiment 2

[0057] Take 20 grams of diclazuril and 80 grams of polyvinylpyrrolidone and dissolve them in 150 milliliters of dimethylformamide, and heat to dissolve them all. The solution was dried under reduced pressure in a vacuum oven to remove dimethylformamide to obtain 100 g of solid. Put it still in the freezer for 24 hours to make it brittle, and then crush it through a 40-mesh sieve to obtain the soluble powder of diclazuril. 100 grams of diclazuril soluble powder obtained with 300 grams of citric acid, 250 grams of sodium bicarbonate and 300 grams of glucose were wetted and granulated with 500 milliliters of ethanol solution of 10% polyvinylpyrrolidone, and the ethanol was evaporated by cold wind to prepare 1000 grams of granules, then whole, pressed into 300 tablets, weighing 3.3 grams.

Embodiment 3

[0059] Take 30 grams of diclazuril and 70 grams of polyvinylpyrrolidone and dissolve them in 200 milliliters of dimethylformamide, and heat to dissolve them all. The solution was dried under reduced pressure in a vacuum oven to remove dimethylformamide to obtain 100 g of solid. Put it still in the freezer for 24 hours to make it brittle, and then crush it through a 60-mesh sieve to obtain the soluble powder of diclazuril. 100 grams of diclazuril soluble powder obtained with 300 grams of fumaric acid, 250 grams of sodium carbonate and 320 grams of glucose were wetted and granulated with 300 milliliters of 10% polyvinylpyrrolidone ethanol solution, and the ethanol was evaporated by cold wind to prepare 1000 grams of granules, then whole, pressed into 200 tablets, weighing 5 grams.

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PUM

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Abstract

The invention discloses a Diclazuril effervescent tablet prepared with Diclazuril soluble power. The Diclazuril soluble power contains 1 to 5 portion of Diclazuril and 9 to 20 portion of polyvinylpyrrolidone by weight. The Diclazuril is diffused in the polyvinylpyrrolidone in form of molecules. The Diclazuril soluble power is mixed evenly with pharmaceutically acceptable disintegrant, pharmaceutically acceptable disintegrant and dispersant, and then is wetted by adhesive to produce granules, which are arranged and tabletted. Then the Diclazuril effervescent tablet is prepared. The Diclazuril soluble power of the invention has the advantages of high dissolution and high bioavailability. The effervescent tablet prepared in the method further improves the treating effects, and the effervescent tablet has the advantages of convenient transport and storage, no need of weighing and direct use, etc, thereby suitable for prevention of coccidiosis in peasant houses and livestock farms. So the invention has wide marketing prospects.

Description

(1) Technical field [0001] The invention relates to an anticoccidiostat for poultry-an effervescent tablet made from the diclazuril soluble powder of the invention. (2) Background technology [0002] Coccidiosis is a common disease in the livestock and poultry industry, especially for the poultry industry. Every year, coccidiosis will cause great harm to the poultry industry. attention. At present, the prevention of coccidiosis mostly adopts the method of adding anticoccidial drugs to the feed, and adding anticoccidial drugs to the feed can prevent the occurrence of coccidiosis to a certain extent. However, when coccidiosis breaks out, the effect of adding anticoccidiostats to the feed is not good. At the same time, due to the small amount of anticoccidiostat and the large feed particles, it is difficult to mix evenly and the operation is inconvenient. It is a better method to treat coccidiosis by adding anticoccidiostats to the drinking water of livestock and poultry. D...

Claims

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Application Information

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IPC IPC(8): A61K31/53A61K9/46A61K47/32A61P33/02
Inventor 杨彩梅刘金松曾新福杨庆华
Owner ZHEJIANG UNIV
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