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Method for preparing coccidium-resistant suspension

A suspension and anti-coccidian technology, which is applied in the direction of medical preparations containing active ingredients, anti-infectives, and pharmaceutical formulas, to achieve the effects of convenient administration, increased dissolution rate, and increased saturation solubility

Inactive Publication Date: 2010-12-08
TIANJIN RINGPU BIO TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0013] The object of the present invention is to provide a suspension containing diclazuril and maduramycin ammonium and its preparation method, to solve the problems of convenient administration, reducing waste and ensuring dosage

Method used

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  • Method for preparing coccidium-resistant suspension
  • Method for preparing coccidium-resistant suspension
  • Method for preparing coccidium-resistant suspension

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Prescription containing diclazuril and maduramycin ammonium anticoccidial suspension:

[0030] components

Dosage

Diclazuril

0.5% (W / V)

Ammonium Maduramycin

2.0% (W / V)

ethanol

3% (V / V)

sodium lauryl sulfate

0.06% (W / V)

glycerin

8% (V / V)

sodium bicitrate

2% (W / V)

Disodium edetate

0.05% (W / V)

Double long chain quaternary ammonium salt

0.03% (W / V)

[0031] Methylparaben

0.03% (W / V)

purified water

Add to 100% (V / V)

[0032] The preparation method of diclazuril and maduramycin ammonium anticoccidial suspension:

[0033] (1) First dissolve sodium bicitrate into a small amount of purified water, then add diclazuril, ammonium maduramycin, ethanol and sodium lauryl sulfate, and stir to obtain solution A.

[0034] (2) Take an appropriate amount of purified water, add methyl paraben, heat to dissolve, and place it at room temperature, then add ...

Embodiment 2

[0039] Prescription containing diclazuril and maduramycin ammonium anticoccidial suspension:

[0040] components

Dosage

Diclazuril

1% (W / V)

Ammonium Maduramycin

5% (W / V)

ethanol

5% (V / V)

glycerin

12% (V / V)

sodium bicitrate

2.5% (W / V)

Disodium edetate

0.05% (W / V)

phenol

0.5% (W / V)

purified water

Add to 100% (V / V)

[0041] Preparation method containing diclazuril and maduramycin ammonium anticoccidial:

[0042] (1) Dissolve sodium hydrogen citrate into a small amount of purified water first, then add diclazuril, ammonium maduramycin and ethanol, and stir to obtain solution A.

[0043] (2) Take an appropriate amount of purified water, add disodium edetate, stir until dissolved, and obtain solution B.

[0044](3) Take glycerin, add molten phenol, stir evenly, and obtain solution C.

[0045] (4) Pour solution B and solution C into solution A, stir and mix well, and then dis...

Embodiment 3

[0049] Product Stability Test

[0050] 1. Materials

[0051] 1.1 Diclazuril solution

[0052] 1.2 Suspension: anticoccidial suspension containing diclazuril and maduramycin ammonium

[0053] 2 methods

[0054] The solution and the suspension were respectively placed in an incubator with a temperature of 40°C and a relative humidity of 75%, and stability tests were carried out before and after 1 month, 2 months and 6 months.

[0055] 3. Experimental results

[0056] The stability experiment result of table 1 solution and suspension

[0057]

[0058] As can be seen from the experimental results, the color, content and related substance items of the suspension are all relatively stable, while the color, content and related substance items of the solution vary greatly. This shows that the stability of the suspension is obviously better than that of the solution. Solution.

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Abstract

The invention relates to a method for preparing coccidium-resistant suspension containing Diclazuril and maduramicin ammonium. A user can take the suspension with water; and diluted stock solution can be uniformly dispersed in water and keep the stable suspension state, and has the characteristics of convenient administration, waste reduction, dosage guarantee, high dissolution rate of medicaments, high saturated solubility of the medicaments, long detention time of the medicaments in vivo, high bioavailability, no blockage of drinkers and the like. The coccidium-resistant suspension containing the Diclazuril and the maduramicin ammonium can fully exert the medical effect when treating chicken coccidiosis.

Description

technical field [0001] The invention belongs to the field of veterinary medicine, in particular to an anticoccidial suspension and a preparation method thereof. Background technique [0002] Chicken coccidiosis is a parasitic disease that seriously harms the poultry industry produced by Eimeria. There are 7 species of Eimeria parasitizing in chicken intestines, namely Eimeria tenella, E.acervulina, Eimeria poisonous ( E. necatrix), E. maxima, E. mitis, E. brinetti and E. precocious (E. .praecox). Various coccidia parasitize in different parts of the digestive tract of chickens. Eimeria tenella parasitizes in the cecum, Eimeria heaps parasitizes in the duodenum, Eimeria giant and Eimeria venom Parasitic in the small intestine, Eimeria brucei parasitizes in the lower small intestine and rectum. [0003] Chicken coccidiosis is distributed in a wide range of areas, and chicken coccidiosis occurs in almost all places where chickens are raised. According to literature reports...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61K31/53A61K9/10A61P33/02
Inventor 富艳玲
Owner TIANJIN RINGPU BIO TECH
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