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Specific medicine used for treating coccidiosis and preparation method of specific medicine

A technology for chicken coccidiosis and a specific drug, which is applied in the fields of animal medicine and medical engineering, can solve the problems of reducing the cost of coccidiosis prevention and control, the single efficacy of the effective components, and the imprecise formula, and achieves the advantages of being conducive to application and promotion, and good dispersion. Effect, effect of high drug bioavailability

Inactive Publication Date: 2015-10-28
FUJIAN BRADY PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The present invention provides a specific medicine for treating coccidiosis in chickens and a preparation method thereof, which overcomes the fact that most of the known anticoccidiosis medicines are not easily soluble in water, and most of them are not easy to dissolve in water due to unscrupulous formulas or mostly single effective components. In response to the defects of poor curative effect, there is an urgent need for more diverse and flexible drug application measures to improve its sensitivity to coccidiosis and reduce the market demand for the ever-increasing cost of coccidiosis control, providing a A specific drug for treating chicken coccidiosis and a preparation method thereof having many advantages such as strong specificity, quick effect, short drug withdrawal period, high mortality rate control and reduction, drug resistance reduction, and high drug bioavailability

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Embodiment 1: A kind of specific medicine for treating coccidiosis in chickens, the weight-number ratio of each component contained in the medicament of every 100 mL is: diclazuril 0.45 g, decoquinate 4.4 g, toltrex Zhuli 1.8 g, polyethylene glycol 35 mL, propylene glycol 15 mL, ethanolamine 0.75 mL, ethylparaben 0.1 g, dimethylformamide 35 mL, Tween 80 15 mL.

[0017] The above-mentioned preparation method for the specific drug for the treatment of chicken coccidiosis comprises the following steps:

[0018] (1) Water phase preparation: Add 15 mL of propylene glycol into the water phase tank, stir at a speed of 50 rpm / min; then add ethanolamine dropwise at a rate of 1.0 mL / min until the ethanolamine reaches 0.75 mL, thereby preparing into water phase;

[0019] (2) Oil phase preparation: Mix 35 mL of polyethylene glycol and 35 mL of dimethylformamide to form an emulsifier, then add 0.1 g of ethylparaben, 0.45 g of diclazuril, and 4.4 g of Decoquinate and 1.8 g of toltr...

Embodiment 2

[0022] Embodiment 2: A kind of specific drug for treating coccidiosis in chickens, the weight-number ratio of each component contained in the medicament of every 100 mL is: diclazuril 0.55 g, decoquinate 3.6 g, toltrex Zhuli 2.2 g, polyethylene glycol 35 mL, propylene glycol 15 mL, ethanolamine 0.75 mL, ethylparaben 0.1 g, dimethylformamide 35 mL, Tween 80 15 mL.

[0023] The above-mentioned preparation method for the specific drug for the treatment of chicken coccidiosis comprises the following steps:

[0024] (1) Water phase preparation: Add 15 mL of propylene glycol into the water phase tank, stir at a speed of 70 rpm / min; then add ethanolamine dropwise at a rate of 0.5 mL / min until the ethanolamine reaches 0.75 mL, thereby preparing into water phase;

[0025] (2) Oil phase preparation: Mix 35 mL of polyethylene glycol and 35 mL of dimethylformamide to form an emulsifier, then add 0.1 g of ethylparaben, 0.55 g of diclazuril, and 3.6 g of The decoquinate and 2.2 g of toltraz...

Embodiment 3

[0029] Select the same batch of 120 healthy chicks, male and female half and half, average weight, not immunized with any vaccines such as chicken coccidian vaccine, fed under clean and ventilated conditions, fed compound feed without adding antibiotics and anticoccidial drugs and cleaned Tap water, ad libitum feeding. When being raised to the age of 25 days, they were randomly divided into 4 groups, 30 in each group, artificially infected with Eimeria tenella in the 1st to 3rd groups, and after 48 h of infection, the first group was treated with chicken coccidiosis prepared in Example 1. The dose of 50 ml of specific drug 50 ml mixed with water 200 Kg is mixed with clean tap water, and administered continuously for 3 days; drink, continuous administration for 3 days; the third group was set as the infection control group without treatment; the fourth group was the healthy control group. The survival rate, average weight gain, relative weight gain rate, lesion value, oocyst v...

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Abstract

The invention discloses a specific medicine used for treating coccidiosis and a preparation method of the specific medicine. The specific medicine is mainly prepared from diclazuril, decoquinate and toltrazuril. Every 100 ml of the medicament comprises, by weight, 0.45-0.55 g of diclazuril, 3.6-4.4 g of decoquinate and 1.8-2.2 g of toltrazuril. The preparation method comprises the fours steps of aqueous preparation, oil phase preparation, emulsion and dissolution promotion. The pecific medicine is mainly prepared from diclazuril, decoquinate and toltrazuril. The effect of treating the coccidiosis is improved through the synergistic effect of diclazuril, decoquinate and toltrazuril, and the drug resistance is lowered. Formed double solvents can effectively improve the solubility of the main medicine components in water, and main medicine can be stable in the preparation and is easily dissolved in water. Meanwhile, the special medicine has the advantages of being capable of taking effects fast, short in drug withdrawal period, high in death rate control and reduction, high in drug bioavailability and the like.

Description

technical field [0001] The invention relates to the technical fields of animal medicine and medical engineering, in particular to a specific drug for treating chicken coccidiosis and a preparation method thereof. Background technique [0002] Since the reform and opening up, my country's aquaculture industry has developed rapidly, especially the chicken industry. The total amount of chickens on hand has ranked first in the world, and it has become a veritable chicken-raising country. However, with the expansion of the chicken industry, frequent movement and increased density, chicken diseases have become an important factor affecting or restricting the healthy and sustainable development of the chicken industry. Coccidiosis is currently a global protozoan disease that seriously harms the chicken industry and has the highest incidence rate. The disease often breaks out in 4-6 week-old chicken flocks, causing 20-80% mortality rates, huge economic losses, and sometimes Even de...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/53A61K47/34A61P33/02A61K31/47
Inventor 赵军肖建设杨荣平潘慧青张炎达赵清国史金慧邓翠芬林贺桂王新
Owner FUJIAN BRADY PHARMA CO LTD
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