Preparation method of proanthocyanidin

A proanthocyanidin and raw material technology, applied in the field of proanthocyanidin preparation, can solve the problems of inability to carry out large-scale industrial production and immature process, and achieve the effects of easy continuous production operation, short process flow and high separation efficiency

Inactive Publication Date: 2012-05-02
GUANGXI JINHONGXIN BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The aqueous two-phase method has been reported, but the process is immature. It is a l

Method used

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  • Preparation method of proanthocyanidin
  • Preparation method of proanthocyanidin

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Add 5 parts by weight of proanthocyanidin raw materials that have been removed, coarsely crushed or cut into sections into a stainless steel reaction tank, add the raw materials and 70% ethanol in a ratio of 1:3 by weight, heat and keep warm for extraction three times, and control the temperature at 50-60°C. The incubation time is 1.2h, and the extracts are combined. Add the extract to a stainless steel reaction kettle, add 2% polyacrylic acid and water or ethanol to the extract, adjust the ethanol content to 30-40% of the solution, stir evenly, let stand for 1.5h to form two phases, and obtain the upper phase extraction liquid, add 4 parts by weight (5:1, v / v) of two-phase extractant ethyl acetate-petroleum ether that is insoluble in water and water-soluble to extract, separate the extract, and distill the filtrate to reclaim the organic solvent, and finally control the temperature to be 60 Below ℃, the vacuum degree is above 0.08Mpa to carry out vacuum drying to obtai...

Embodiment 2

[0041] Add 5 parts by weight of proanthocyanidin raw materials that have been removed, coarsely crushed or cut into sections into a stainless steel reaction tank, add the raw materials and 70% ethanol in a ratio of 1:3 by weight, heat and keep warm for extraction three times, and control the temperature at 50-60°C. The incubation time is 1.2h, and the extracts are combined. Then add the extract of the extract into the enamel reaction kettle, add the extract 3% methyl polypropylene glycol and water or ethanol, adjust the ethanol content to 30-40% ethanol of the solution, stir evenly, and let it stand for 1h to form two phases , to obtain the upper phase extract, add water-insoluble and water-soluble two-phase extractant ethyl acetate-petroleum ether 4 parts by weight (5: 1, v / v) for extraction, separate the extract, distill the filtrate to reclaim the organic solvent, and finally The temperature is controlled below 60°C, and the vacuum degree is above 0.08Mpa for vacuum drying ...

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Abstract

The invention discloses a preparation method of proanthocyanidin. In the method, grape seed, pine bark, purple potato or any other plant with high proanthocyanidin content is used as a raw material, an ethanol aqueous solution is used as an extraction solvent, and a double water phase extraction method is utilized to efficiently prepare proanthocyanidin from a crude proanthocyanidin extract. The invention has the advantages of high product yield, high product purity, low solvent consumption, low cost and the like, and can easily implement industrial production.

Description

technical field [0001] The invention belongs to the technical field of biological extraction, and relates to a preparation method of proanthocyanidins. Background technique [0002] Proanthocyanidins, the English name is Oligomeric Proantho Cyanidins (OPC), is a bioflavonoid with a special molecular structure, is currently internationally recognized as the most effective natural antioxidant for removing free radicals in the human body. It is generally a reddish-brown powder with a slight gas and astringent taste, soluble in water and most organic solvents. Generally, it is grape seed extract, French maritime pine bark extract or purple potato extract. Proanthocyanidin is a new type of high-efficiency antioxidant, the most powerful free radical scavenger found so far, and has very strong activity in vivo. Experiments have proved that OPC's ability to resist free radical oxidation is 50 times that of vitamin E and 20 times that of vitamin C, and it can be absorbed quickly an...

Claims

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Application Information

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IPC IPC(8): C07D311/62
Inventor 罗亚东关健敏
Owner GUANGXI JINHONGXIN BIOTECH
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