Resin process of extracting proanthocyanidin from graup seed

A grape seed and anthocyanin technology is applied in the field of extraction of proanthocyanidins in plants, and can solve problems such as difficulty in large-scale industrial production, difficulty in meeting standards, increase in production cost, etc., and achieves low cost, no solvent residue, and production saving. cost effect

Inactive Publication Date: 2004-06-23
沈阳中科药业有限责任公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Foreign patentees have the problem that the raw materials are not easy to obtain, and the production process includes poisonous (chloroform), flammable (ethyl acetate, petroleum fans), volatile organic solvents, or production under low temperature conditions, and the final

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Take 100g of grape seeds, extract three times with 50% ethanol at 80°C, use 500ml of solvent each time for 2 hours, filter and recover the filtrate, distill the filtrate (i.e. recover ethanol) until there is no alcohol smell, add 1 times water to the solution and filter to remove Impurities, treated D101 macroporous adsorption resin on the filtrate, washed with water until nearly colorless, eluted with 60% ethanol, distilled eluent to recover ethanol, obtained mother liquor, dried to obtain 6g of finished product, proanthocyanidin content was 78%.

Embodiment 2

[0016] Take 100g of grape seeds and extract them three times with water at 50°C, using 500ml of water each time for 2 hours, then filter and recover the filtrate, wash the treated D201 macroporous adsorption resin on the filtrate until nearly colorless, and elute with 85% ethanol. The eluate was distilled to recover ethanol to obtain the mother liquor, which was dried to obtain 4.2 g of the finished product with a proanthocyanidin content of 85.6%.

Embodiment 3～7

[0018] The differences from Example 1 are shown in Table 1 below, and other conditions are the same as in Example 1.

[0019] serial number

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PUM

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Abstract

The present invention relates to the extraction of proanthocyanidin from plant material, and is especially the resin extraction process of proanthocyanidin from grape seed. Grape seed as material is extracted with water and/or alcohol as solvent at normal temperature or heating condition; the extractive liquid is filtered, concentrated while recovering alcohol solvent, re-filtered while adding water, the filtrate is adsorbed with macroporous adsorptive resin, the saturated resin is eluted with water solution of alcohol and the eluent is dried while recovering solvent to obtain the product. The process has yield of 3-10 %, and the product has proanthocyanidin content of 38-90 %. The present invention has the advantages of low cost and no residual solvent in the product, and is environment friendly and suitable for industrial production.

Description

technical field [0001] The invention relates to the extraction of proanthocyanidins in plants, in particular to a method for extracting proanthocyanidins in grape seeds by a resin method. Background technique [0002] Proanthocyanidins are polymers of flavonoids such as flavan-3,4 diols and flavanols, and most plants contain proanthocyanidins. However, plants such as pine bark, grape seed, and lemon bark contain more; these compounds, especially oligomeric proanthocyanidins (opc), can significantly improve the anti-aging ability of the body and improve heart function by removing excess free radicals in the body. Enhance the ability of the human body to resist allergies; pharmacological experiments show that it has a strong inhibitory effect on diseases such as arteriosclerosis, gastric ulcer, colon cancer, cataract, and diabetes complications; the antioxidant capacity of proanthocyanidins is 200 times that of vitamin C, and that of vitamin E 50 times, it is the natural anti...

Claims

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Application Information

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IPC IPC(8): C07D311/62C07D493/18
Inventor 王世成傅星朱丹
Owner 沈阳中科药业有限责任公司
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