The invention relates to a medicine composition containing a hepatic cell growth factor receptor (cMet) inhibitor and a Bcl-2 inhibitor and an application of the medicine composition in preparing medicine for treating colon cancers, liver cancers, lung cancers, kidney cancers, stomach cancers, brain tumors, sarcoma, glioma, pancreatic cancers, ovarian cancers, breast cancers or prostate cancers. The medicine composition containing the cMet inhibitor and the Bcl-2 inhibitor has a remarkable synergistic effect, and thereby the curative effect of medicine is improved, the medicine dosage is reduced and the side effect is reduced.