The invention discloses a comprehensive security monitoring method and a comprehensive security monitoring system based on a sentry. The comprehensive security monitoring method includes the following implementation steps: 1) setting a sleep pulse critical value, a life weak pulse critical value and a human movement sign critical value; and 2) collecting pulse and human movement signs of sentry security personnel in real time. Security monitoring alarm is achieved according to three factors of the pulse, the human movement signs and manually triggered alarm, a sentry site video is collected through a camera during the triggered alarm, and alarm and the site video collected by the camera are sent to a monitoring center. The comprehensive security monitoring system comprise the monitoring center and at least one sentry unit, the sentry unit comprises a video monitoring unit, a sentry base station and at least one security personnel terminal, the video monitoring unit comprises the camera with a rotary platform, and the security personnel terminal comprises a pulse sensor, an attitude sensor, an alarm button, a terminal controller and a terminal wireless module. The comprehensive security monitoring method and the comprehensive security monitoring system based on the sentry have the advantages of being good in security, high in reliability, accurate in video monitoring and simpleand convenient to use.