Method for producing 4-pentafluoride-sulfanyl-benzoylguanidines

An alkyl and compound technology, applied in organic chemistry, pharmaceutical formulations, in vivo radioactive preparations, etc., can solve the problems of huge technical complexity, low yield, unsuitable reagents and reaction conditions, etc.
CN101475519BInactive Publication Date: 2012-04-25SANOFI AVENTIS DEUT GMBH
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
SANOFI AVENTIS DEUT GMBH
Publication Date
2012-04-25
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to a method for producing 4-pentafluoride-sulfanyl-benzoylguanidines of formula (I) wherein groups from R1 to R4 correspond to meanings given in claims. The compounds of the formula (I) constitute NHE1 inhibitors and can be used for curing cardiovascular diseases.
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Description

[0001] This application is a divisional application, the application number of the original application is 200480033480.6, the application date is November 3, 2004, and the title of the invention is "method for preparing 4-thiobenzoylguanidine pentafluoride". technical field

[0002] The present invention relates to a process for the preparation of 4-pentafluorothiobenzoylguanidine of formula I. Compounds of formula I are NHE1 inhibitors and are useful, for example, in the treatment of cardiovascular disorders. Background technique

[0003] German application 10222192 describes pentafluorothiobenzoylguanidines as NHE1 inhibitors. However, the methods described therein for the preparation of these compounds have low yields, require reagents and reaction conditions which cause great technical complexity or are not suitable for large-scale preparations. Contents of the invention

[0004] It has now been found that a new and highly efficient synthetic method which avoids the ...

Claims

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