Botulinum Toxin and the Treatment of Primary Disorders of Mood and Affect

a neurotoxin and botulinum toxin technology, applied in the field of treating primary disorders of mood and affect with a neurotoxin, can solve the problems of not being able to direct injection into the brain, ssris also produces numerous side effects, and major depression is particularly disabling and pernicious, so as to reduce agitation behavior, reduce and reduce the effect of at least one central nervous system neurotransmitter
US20150086532A1Inactive Publication Date: 2015-03-26REVANCE THERAPEUTICS INC
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Patent Information

Authority / Receiving Office
US · United States
Patent Type
Applications(United States)
Current Assignee / Owner
REVANCE THERAPEUTICS INC
Publication Date
2015-03-26
Estimated Expiration
Not applicable · inactive patent

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Abstract

A method of treating major depression comprising the steps of: identifying a subject with one or more symptoms of a depressive disorder; and administering a botulinum toxin to soft tissues outside the neurocranium using an injection selected from the group consisting of: a transdermal injection; a subcutaneous injection; and a percutaneous injection; and thereby reducing at least one symptom of depression.
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Description

[0001] This application claims benefit to U. S. Provisional Application Ser. No. 60 / 690,162, filed on Jun. 14, 2005; U. S. Provisional Application Ser. No. 60 / 693,771, filed on Jun. 27, 2005; U. S. Provisional Application Ser. No. 60 / 721,060, filed on Sep. 28, 2005; U. S. Provisional Application Ser. No. 60 / 738,981, filed on Nov. 23, 2005, all of which are hereby incorporated herein by reference in their entireties.FIELD OF THE INVENTION

[0002] The present invention relates to the treatment of primary disorders of mood and affect with a neurotoxin, including depressive, anxiety and sleep disorders as well as other CNS disorders.BACKGROUND OF THE INVENTION

[0003] Depression is one of the most prevalent and pervasive forms of mental illness that affects individuals across age and gender lines. (Gainotti et al. (2001) J. Neural Neurosurg. Psychiatr. 71: 258-261; Wong et al. (2001) Nature Rev. Neurosci. 2: 343-351; Nestler et al. (2002) Neuron 34: 13-25). The lifetime risk of major depressio...

Claims

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