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4 results about "Treatment-resistant depression" patented technology
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Treatment-resistant depression (TRD) is a term used in clinical psychiatry to describe a condition that affects people with major depressive disorder (MDD) who do not respond adequately to a course of appropriate antidepressant medication within a certain time. Typical definitions of TRD vary, and they do not include a resistance to psychological therapies. Inadequate response has traditionally been defined as no clinical response whatsoever (e.g. no improvement in depressive symptoms). However, many clinicians consider a response inadequate if the person does not achieve full remission of symptoms. People with treatment-resistant depression who do not adequately respond to antidepressant treatment are sometimes referred to as pseudoresistant. Some factors that contribute to inadequate treatment are: early discontinuation of treatment, insufficient dosage of medication, patient noncompliance, misdiagnosis, and concurrent psychiatric disorders. Cases of treatment-resistant depression may also be referred to by which medications people with TRD are resistant to (e.g.: SSRI-resistant). In TRD adding further treatments such as psychotherapy, lithium, or aripiprazole is weakly supported as of 2019.
Induction regimen for administering 2-(2-chlorophenyl)-2-(methylamino)cyclohexan-1-one
The present invention relates to a dosing regimen of 2-(2-chlorophenyl)-2-(methylamino)cyclohexan-1-one, also known as ketamine, or a derivative thereof for use in the treatment of depression, in particular treatment resistant depression.
Owner:HMNC HOLDINGS
Monoacylglycerol Lipase Modulators
Fused compounds of Formula (I) and Formula (II), pharmaceutical compositions containing them, methods of making them, and methods of using them including methods for treating disease states, disorders, and conditions associated with MGL modulation, such as those associated with pain, psychiatric disorders, neurological disorders (including, but not limited to major depressive disorder, treatment resistant depression, anxious depression, bipolar disorder), cancers and eye conditions.Wherein R1, R2, R2a, R3, R3a, R4, and R4a are defined herein.
Owner:JANSSEN PHARMA NV
Bupropion dosage forms with reduced food and alcohol dosing effects
This disclosure relates to dosage forms comprising bupropion hydrochloride, another salt form of bupropion, or the free base form of bupropion; dextromethorphan hydrobromide, another salt form of dextromethorphan, or the free base form of dextromethorphan, and a polymer. In some embodiments, the dosage form has no significant dose dumping of bupropion in the presence of ethanol in vitro. In some embodiments, the dosage form does not have a food effect for bupropion or dextromethorphan when taken with a high-fat meal in human subjects. Some embodiments include a method of treating a nervous system condition (such as depression, e.g., major depressive disorder, including treatment-resistant depression, agitation associated with Alzheimer's disease (or agitation associated with dementia of the Alzheimer's type), agitation associated with dementia, anxiety (or generalized anxiety disorder), neuropathic pain, or peripheral diabetic neuropathic pain) comprising, administering a dosage form described herein to a human being in need thereof.
Owner:ANTECIP BIOVENTURES II LLC
A synergistic neuromodulation system for treatment-resistant depression
The application discloses a kind of synergic neuromodulation systems for refractory depression, it is related to neuromodulation technical field, including: obtaining individual historical conversation data to establish reference quantity, collect cortical physiology and salivary cortisol data to calculate cortical inhibition proxy quantity and axis drive proxy quantity;The above proxy quantity is standardized based on individual reference quantity and generates continuous flip point intensity;According to flip point intensity, the total stimulation load benchmark is continuously distributed as cortical stimulation component load and vagus-related regulation component load, and each component load is mapped into synergic control instruction to drive equipment to execute stimulation.The application quantifies physiological state and adaptively distributes load, avoids the reversal of stimulation effect under specific state, and improves treatment stability.
Owner:樊亚会