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Pharmacogenomic decision support for modulators of the nmda, glycine, and ampa receptors

A technology of regulators and drugs, applied in the fields of genomics, drugs or prescriptions, proteomics, etc.

Pending Publication Date: 2021-11-09
RGT UNIV OF MICHIGAN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Thus, rTMS and ketamine exhibit similar mechanisms of action to alleviate TRD, but about half of all TRD patients do not respond to treatment with either treatment option

Method used

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  • Pharmacogenomic decision support for modulators of the nmda, glycine, and ampa receptors
  • Pharmacogenomic decision support for modulators of the nmda, glycine, and ampa receptors
  • Pharmacogenomic decision support for modulators of the nmda, glycine, and ampa receptors

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Embodiment Construction

[0054] While the following text sets forth a detailed description of many different embodiments, it should be understood that the legal scope of this description is defined by the words of the claims set forth at the conclusion of this disclosure. The detailed description should be construed as exemplary only and does not describe every possible embodiment since describing every possible embodiment would be impractical, if not impossible. There are many alternative embodiments, which could be implemented, using either current technology or technology developed after the filing date of this patent, which would still fall within the scope of the claims.

[0055] It should also be understood that there is no intention to limit the meaning of said term unless the term is expressly defined in this patent using the sentence "As used herein, the term '______' is defined herein to mean..." or a similar sentence, whether express or implied, beyond their plain or ordinary meaning, and t...

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Abstract

Methods for identifying patients diagnosed with treatment resistant or refractory depression, pain or other clinical indications who are eligible to receive N-methyl-D-aspartate receptor antagonist, glycine receptor beta (GLRB) modulator, or alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR)-based therapies to include determining the appropriate medication, an optimal dose for each patient, and determining which patients are not eligible to receive the therapy. The pharmacogenomic clinical decision support assays include targeted single nucleotide polymorphisms and clinical values or a combination of targeted single nucleotide polymorphisms, targeted ketamine- specific expansion and contraction of topologically associated domains, and clinical values. The methods described herein allow for a more effective determination of which patients will experience drug efficacy and which patients will experience adverse drug events. The methods provide personalized patient recommendations for dose, the frequency of medication administration, and recommendations on drug choice.

Description

[0001] References to related applications [0002] This application requires an application titled "Methods and Systems to Reconstruct DrugSpatial Networks from Pharmacogenomic Regulatory Interactions and Uses Thereof" submitted on January 23, 2019 (1) U.S. Provisional Application Serial No. 62 / 795,705 and entitled "Companion Diagnostic Assays for N-Methyl-D-Aspartate Receptor Modulators" filed on January 23, 2019 methyl-D-Aspartate Receptor Modulators)" (2) U.S. Provisional Application Serial No. 62 / 795,710, the entire disclosure of each of which is hereby expressly incorporated by reference This article. technical field [0003] The technique described here is related to pharmacogenomic clinical decision support assays and can be used to select N-methyl-D-aspartate (NMDA) receptors, glycine receptors, and α-amino-3-hydroxy-5- Therapy of methyl-4-isoxazolepropionic acid (AMPA) receptors for depression (especially treatment-resistant or treatment-resistant depression) and o...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G16H20/10
CPCG16H20/10G16B5/00G16B40/00G16B45/00G16B50/10G16B30/00G16H50/20G16H50/50G16B5/10
Inventor B·D·阿西G·A·希金斯A·艾德A·卡利宁N·里马鲁恩J·S·伯恩斯
Owner RGT UNIV OF MICHIGAN
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