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Combined medicine for curing treatment-resistant depression and applications thereof

A depression and refractory technology, applied in drug combinations, medical preparations containing active ingredients, pharmaceutical formulas, etc.

Inactive Publication Date: 2011-07-27
SHANGHAI MENTAL HEALTH CENT (SHANGHAI PSYCHOLOGICAL COUNSELLING TRAINING CENT)
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no report on a combination drug consisting of paroxetine and sodium valproate for the treatment of refractory depression

Method used

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  • Combined medicine for curing treatment-resistant depression and applications thereof
  • Combined medicine for curing treatment-resistant depression and applications thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] (1) Method

[0016] 1.1 Object

[0017] This study is a randomized, double-blind multi-center (8 centers) study, from January 2005 to December 2007, inclusion and exclusion criteria:

[0018] (1) Meet the diagnostic criteria of DSM-IV "major depressive episode";

[0019] (2) The current episode has been treated for 2 months, and the 17-item Hamilton Depression Scale (HAMD-17) score is still ≥ 17 points;

[0020] (3) The 17-item Hamilton Depression Scale (HAMD-17) score was still ≥ 17 at the time of enrollment;

[0021] (4) 18-65 years old, male or female;

[0022] (5) Junior high school education or above;

[0023] (6) Sufficient audio-visual level to complete the examinations necessary for the study.

[0024] (7) Exclude those who are currently suffering from serious physical diseases, those who have serious suicide attempts, and pregnant or lactating women;

[0025] (8) Exclude patients diagnosed with bipolar disorder who are currently suffering from depression;...

Embodiment 2

[0054] Chinese patent application number 200910002812.9 discloses an antidepressant drug combination preparation and its application method and use. The invention discloses an antidepressant drug combination preparation, especially a drug combination preparation comprising trazodone and other antidepressant drugs. , and its use in the preparation of medicaments for treating depression.

[0055] Fluoxetine + trazodone group: prepare the joint preparation according to the method disclosed in Chinese Patent Application No. 200910002812.9, fluoxetine (44.8 mg) + trazodone (100 mg);

[0056] Paroxetine + trazodone group: paroxetine (20mg) + trazodone (100mg);

[0057] Paroxetine + sodium valproate group: paroxetine (20mg) + sodium valproate (600mg).

[0058] Referring to the method of Example 1, 150 patients with refractory depression were randomly divided into 3 groups, and received the above three combination drugs for 8 weeks. A total of 121 (80.7%) patients completed the 8-we...

Embodiment 3

[0061] The preparation of embodiment 3 combination pharmaceutical preparations

[0062] Recipe 1:

[0063] Name of raw material

[0064] Recipe 2:

[0065] Name of raw material

[0066] Carboxymethyl Starch Sodium

[0067] Recipe 3:

[0068] Name of raw material

[0069] Recipe 4:

[0070] Name of raw material

[0071] Recipe 5:

[0072] Name of raw material

[0073] Preparation process: pass through 80-mesh sieve for paroxetine hydrochloride, 100-mesh sieve for sodium valproate, 80-mesh sieve for lactose and carboxymethyl starch sodium, 100-mesh sieve for starch, and 40-mesh sieve for magnesium stearate. Mix paroxetine hydrochloride and lactose evenly, then mix evenly with sodium valproate, then mix evenly with starch, granulate with starch slurry, dry in a 50-degree oven, granulate with a 20-mesh sieve, and punch out φ8mm tablets.

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Abstract

The invention relates to a combined medicine for curing treatment-resistant depression (TRD), which is characterized in that the combined medicine comprises paroxetine and sodium valproate. The invention also provides applications of the combined medicine. The invention has the advantages that the research on the TRD synergia strategy is provided for the first time in China, the combined medicine of paroxetine and sodium valproate, and the applications of the combined medicine in the preparation of medicine for curing the TRD are provided for the first time, the paroxetine combined with the sodium valproate for curing the TRD has higher remission rate, and the tolerance is high, so that the combined medicine can be taken as the new intensive treatment scheme for curing the TRD.

Description

technical field [0001] The invention relates to a combination medicine for treating depression, in particular to a combination medicine for treating refractory depression and application thereof. Background technique [0002] Depression is a common mental disorder with a chronic and recurrent course, which has a great impact on the social function of patients. The World Health Organization (WHO) Global Burden of Disease Cooperative Research predicts that by 2020, depression will become the second leading cause of coronary heart disease after coronary heart disease. Two major sources of disease burden. Most patients with depression respond to medication and psychotherapy, but 40% of patients do not respond to various treatments, which is commonly referred to as treatment-resistant depression (TRD). TRD refers to the diagnostic criteria for depressive episodes in the International Code of Diseases (ICD-10), the fourth edition of the American Diagnostic Criteria for Mental Dis...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4525A61K45/06A61P25/24
Inventor 方贻儒苑成梅易正辉
Owner SHANGHAI MENTAL HEALTH CENT (SHANGHAI PSYCHOLOGICAL COUNSELLING TRAINING CENT)
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