39 results about "Paroxetine Hydrochloride" patented technology

A process for preparing amorphous paroxetine hydrochloride or sertraline hydrochloride is provided, which comprises preparing a solution in which paroxetine hydrochloride or sertraline hydrochloride and a water-soluble polymer are dissolved in a co-solvent of a volatile organic solvent and water. Said solution is dried to obtain a composition comprising amorphous paroxetine hydrochloride or sertraline hydrochloride and the water-soluble matrix.

The invention discloses a tablet containing paroxetine and a preparation method thereof. The tablet is composed of paroxetine hydrochloride and auxiliary materials accepted in pharmacy and prepared in a wet granulation process, thereby not affecting tablet manufacturing modes and guaranteeing quality and stability of tablets. The tablet is simple in preparation method, wide in application scope, convenient to transport and store and suitable for scale production. The preparation method is convenient to operate.

A process for drying paroxetine hydrochloride anhydrate comprising (A) reacting a paroxetine compound with hydrogen chloride in the presence of isopropyl alcohol and crystallizing the resulting product, to obtain paroxetine hydrochloride anhydrate, and drying the resulting paroxetine hydrochloride anhydrate at a temperature of not more than 60° C. and under normal pressure or lower in an atmosphere which does not substantially contain moisture until the content of isopropyl alcohol attains to not more than 15% by weight; and (B) further drying the paroxetine hydrochloride anhydrate at a temperature of 80° to 110°C. in an atmosphere reduced to not more than 20 mm Hg until the content of isopropyl alcohol attains to not more than 5% by weight. According to the present invention, the amount of remaining isopropyl alcohol contained in the paroxetine hydrochloride anhydrate, crystallized in the presence of isopropyl alcohol, can be efficiently reduced in a short period of time without necessitating a large-scaled apparatus.

Crystals of paroxetine hydrochloride ½-hydrate are allowed to separate out by adding water to a solution or suspension comprising paroxetine hydrochloride and a polar organic solvent which contains no water or at most 60% by weight of water to adjust the water content to at least 70% by weight when crystals of paroxetine hydrochloride ½-hydrate are allowed to separate out in a water-containing polar organic solvent. Crystals of paroxetine hydrochloride ½-hydrate being not colored in pink can be allowed to separate out in the presence of hydrogen chloride when crystals of paroxetine hydrochloride ½-hydrate are allowed to separate out in water or a water-containing polar organic solvent.

The invention relates to an Paroxetine Hydrochloride drop pill prepared by utilizing ultramicro disintegration and drop pill manufacturing process, which has the advantages of improving collapse and dissolving speed, dissolving out speed and degree, quick effect, increased medicament stability, reduced adjuvant consumption, lowered production costs, and easiness in carrying and use. oral or swallow administration, It has good compliance, thus is especially suitable for children, the elderly, bedridden patients and dysphagia patients.

The invention relates to a preparation method of an important intermediate of paroxetine hydrochloride for resisting various kinds of depression, which is suitable for industrial production, wherein the formula of the intermediate is shown in formula (1): compound (-)-trans-4R-(4- fluorophenyl)-3S-{[3', 4'-(methylene dioxygen group) phenoxyl] methyl}-1-phenoxy hydroxypiperidine. The invention also relates to a method for finely preparing paroxetine hydrochloride.

The invention provides a novel paroxetine hydrochloride osmotic pump type enteric controlled release tablet. In an osmotic pump type enteric controlled release tablet in an enteric coating, ethyl cellulose and polyvinylpyrrolidone are used as semipermeable membrane formation material, an asymmetric tablet type is preferable, the ageing phenomenon of the semipermeable membrane can be overcome, and the medicine residue is lowered. The invention also provides a method for improving the anti-ageing performance of the paroxetine hydrochloride osmotic pump type enteric controlled release tablet. The method is characterized in that the ethyl cellulose-polyvinylpyrrolidone is adopted to serve as the semipermeable membrane material. In addition, the invention also provides an application of the ethyl cellulose-polyvinylpyrrolidone composite to prepare the paroxetine hydrochloride osmotic pump type enteric controlled release tablet with the anti-ageing performance.

The invention relates to the field of medicine and particularly relates to a paroxetine hydrochloride compound and a synthetic method thereof. The paroxetine hydrochloride compound has the following structural formula. According to the paroxetine hydrochloride compound, ethyl chloroformate for industrial production is used as a demethylation reagent, the reagent is stable, the production condition of demethylation is moderate, the total yield is high and about 75%, and the paroxetine hydrochloride compound accords with the requirement of a 2010 edition of a pharmacopeia and applicable to industrial production.

The invention discloses a paroxetine hydrochloride enteric-coated and sustained-release tablet, which comprises a tablet core, an isolating layer, a semipermeable membrane, an enteric coating and a moistureproof coat; the isolating layer is arranged between the tablet core and the semipermeable membrane, the enteric coating is arranged between the semipermeable membrane and the moistureproof coat,wherein the tablet core is prepared from paroxetine hydrochloride, penetrating agent, filling agent, binding agent and lubricant; the penetrating agent comprises one or more drug release hole. The invention further provides a preparation method of the paroxetine hydrochloride enteric-coated and sustained-release tablet, which includes steps of preparing tablet core grains and performing compression moulding to obtain the tablet core; making the tablet core pass through the isolating layer, the emipermeable membrane, the enteric coating and moistureproof coat, drying to obtain the paroxetine hydrochloride enteric-coated and sustained-release tablet. The paroxetine hydrochloride enteric-coated and sustained-release tablet can effectively control the drug release rate, and keep stable blooddrug concentration and durable drug effect, increase the safety, effectiveness and compliance of patients after taking drugs; the production preparation technique is simple, and the cost is low.

The invention discloses a compound preparation for treating premature ejaculation and erectile dysfunction. The compound preparation is composed of the following medicines by weight: 40-120 mg of sildenafil citrate, and 10-50 mg of paroxetine hydrochloride. The compound preparation has the following beneficial effects: the sildenafil citrate treats the erectile dysfunction, the paroxetine hydrochloride relieves anxiety and depression in patients, so that the treatment effect on the erectile dysfunction is improved; and the paroxetine hydrochloride treats the premature ejaculation, the sildenafil citrate treats side effects of the erectile dysfunction due to the paroxetine hydrochloride, so that the effective rate of the premature ejaculation treatment is improved.

The invention relates to the technical field of drug dosage form structure, and in particular relates to a paroxetine hydrochloride time-controlled release pharmaceutical composition and a preparation method thereof. The paroxetine hydrochloride time-controlled release medicinal composition comprises a paroxetine hydrochloride drug release layer, a coated isolation layer and a coated paroxetine hydrochloride drug release layer. Through a large number of tests and prescription screening, the invention provides the paroxetine hydrochloride time-controlled release pharmaceutical composition for the majority of patients, and fills the domestic blank to meet the needs of clinical medication.

The invention provides a PEG6000-DSPE-paroxetine hydrochloride composite material, and a preparation method thereof. According to the preparation method, paroxetine hydrochloride and amphiphilic polymeric material PEG6000-DSPE are subjected to self assembling solvent evaporation so as to obtain a polymer micelle, freeze drying technology is adopted for freeze drying of the polymer micelle so as toobtain free dried powder, wet granulation is adopted to prepare the oral disintegrating tablet. The preparation method is capable of improving tablet mouthfeel, increasing main drug stability and dissolution rate, and increasing in vivo bioavailability.

The invention relates to a pharmaceutical composition containing paroxetine hydrochloride and its application, belonging to the technical field of medicine. In order to overcome the technical deficiencies of the existing antidepressants that have relatively large side effects and unsustainable drug effects, the present invention provides a pharmaceutical composition containing paroxetine hydrochloride, which consists of paroxetine hydrochloride and silybin. The pharmaceutical composition can significantly improve the behavioral score of depression rats when treating depression, and has a significant improvement effect on the cerebral cortex monoamine neurotransmitters of depression rats, thus playing a role in depression. Very good therapeutic effect.

A process for preparing a paroxetine hydrochloride hydrate, comprising reacting (3S, 4R)-1-tert-butoxycarbonyl-4-(4-fluorophenyl)-3-[(3,4-methylene-dioxy)phenoxymethyl]piperidine with hydrogen chloride in the presence of water, and allowing crystals to separate out from the resulting reaction mixture in the presence of water.

The invention relates to a paroxetine hydrochloride sustained release tablet and belongs to the technical field of pharmacy. According to a technical scheme, the paroxetine hydrochloride sustained release tablet is composed of a sustained release micro-pellet and common excipients. The sustained release micro-pellet is composed of a medicine-carrier layer, a sustained release layer and an enteric layer. The use amount of talcum powder in the sustained release layer is 20-100% of a high-molecular sustained release material in the layer. The use amount of talcum powder in the enteric layer is 50-200% of a high-molecular enteric material in the layer. Through regulation on the use amount of talcum powder, an effect of shading protection on the active component is achieved.

The invention discloses a preparation method of a key intermediate of paroxetine hydrochloride. The preparation method comprises: carrying out benzyl site halogenation on (+)-trans-4-(4-fluorophenyl)-3-hydroxymethyl-1-methylpiperidine as a starting material through a halogenation reagent to obtain a compound II, carrying out an elimination reaction process on the compound II to obtain a compound III, and carrying out catalytic hydrogenation reduction on the compound III to obtain (+)-trans-4-(4-fluorophenyl)-3-hydroxymethyl-1-methylpiperidine. The preparation method can convert a by-product (+)-trans-4-(4-fluorophenyl)-3-hydroxymethyl-1-methylpiperidine, which cannot be directly utilized, into (+/-)-trans-4-(4-fluorophenyl)-3-hydroxymethyl-1-methylpiperidine. The product can be directly used as an intermediate for synthesizing paroxetine hydrochloride, change wastes into valuables, improve the benefits of enterprises and reduce the input cost of the enterprise.

A process for preparing paroxetine A hydrochloride includes such steps as adding semi-hydrous paroxetine hydrochloride and solvent (oxylipohydrocarbon derivative) to the crystallizer with jacket, heating, stirring, natural cooling while educting out crystal, and stirring for 30-120 min.