Paroxetine hydrochloride oral disintegrating tablet
A technology of paroxetine hydrochloride and oral disintegrating tablets, which can be used in drug combinations, nervous system diseases, organic active ingredients, etc., and can solve problems such as poor compliance
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Examples
Embodiment 1
[0016] .
[0017] Preparation Process
[0018] The prescription amount of PEG6000-DSPE and paroxetine hydrochloride were fully dissolved in ethanol, and the organic solvent was removed by rotary evaporation under reduced pressure at 37°C for 1 hour in an eggplant-shaped bottle to obtain a uniform film. Add the buffer solution preheated at 37°C and place it in a 37°C water bath. The pot is rotated for hydration, the obtained geopolymer micelles are sized through a 0.45 μm microporous filter membrane, and the filtrate is lyophilized through a freeze dryer to obtain drug-loaded polymer micelle powder.
[0019] The prepared drug-loading polymer micelle powder was mixed with the prescribed amount of mannitol, microcrystalline cellulose, and low-substituted hydroxypropyl cellulose in sequence. Pure water was used as a wetting agent, granulated by 24 mesh sieve, and oven at 50℃ Blast drying, drying the moisture to 1-3%, pass the dried granules through a 24-mesh sieve, weigh them, and calc...
Embodiment 2
[0021] .
[0022] Preparation Process
[0023] The prescription amount of PEG6000-DSPE and paroxetine hydrochloride were fully dissolved in ethanol, and the organic solvent was removed by rotary evaporation under reduced pressure at 37°C for 1 hour in an eggplant-shaped bottle to obtain a uniform film. Add the buffer solution preheated at 37°C and place it in a 37°C water bath. The pot is rotated for hydration, the obtained geopolymer micelles are sized through a 0.45 μm microporous filter membrane, and the filtrate is lyophilized through a freeze dryer to obtain drug-loaded polymer micelle powder.
[0024] The prepared drug-loading polymer micelle powder was mixed with the prescribed amount of mannitol, microcrystalline cellulose, and low-substituted hydroxypropyl cellulose in sequence. Pure water was used as a wetting agent, granulated by 24 mesh sieve, and oven at 50℃ Blast drying, drying the moisture to 1-3%, pass the dried granules through a 24-mesh sieve, weigh them, and calc...
Embodiment 3
[0026] .
[0027] Preparation Process
[0028] The prescription amount of PEG6000-DSPE and paroxetine hydrochloride were fully dissolved in ethanol, and the organic solvent was removed by rotary evaporation under reduced pressure at 37°C for 1 hour in an eggplant-shaped bottle to obtain a uniform film. Add the buffer solution preheated at 37°C and place it in a 37°C water bath. The pot is rotated for hydration, the obtained geopolymer micelles are sized through a 0.45 μm microporous filter membrane, and the filtrate is lyophilized through a freeze dryer to obtain drug-loaded polymer micelle powder.
[0029] The prepared drug-loading polymer micelle powder was mixed with the prescribed amount of mannitol, microcrystalline cellulose, and low-substituted hydroxypropyl cellulose in sequence. Pure water was used as a wetting agent, granulated by 24 mesh sieve, and oven at 50℃ Blast drying, drying the moisture to 1-3%, pass the dried granules through a 24-mesh sieve, weigh them, and calc...
PUM
Login to view more Abstract
Description
Claims
Application Information
Login to view more - R&D Engineer
- R&D Manager
- IP Professional
- Industry Leading Data Capabilities
- Powerful AI technology
- Patent DNA Extraction
Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.
© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap