Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Paroxetine hydrochloride oral disintegrating tablet

A technology of paroxetine hydrochloride and oral disintegrating tablets, which can be used in drug combinations, nervous system diseases, organic active ingredients, etc., and can solve problems such as poor compliance

Active Publication Date: 2018-12-07
万全万特制药江苏有限公司
View PDF5 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Paroxetine hydrochloride crude drug has a strong bitter and numbing taste, and the patient's compliance with taking it is poor

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] .

[0017] Preparation Process

[0018] The prescription amount of PEG6000-DSPE and paroxetine hydrochloride were fully dissolved in ethanol, and the organic solvent was removed by rotary evaporation under reduced pressure at 37°C for 1 hour in an eggplant-shaped bottle to obtain a uniform film. Add the buffer solution preheated at 37°C and place it in a 37°C water bath. The pot is rotated for hydration, the obtained geopolymer micelles are sized through a 0.45 μm microporous filter membrane, and the filtrate is lyophilized through a freeze dryer to obtain drug-loaded polymer micelle powder.

[0019] The prepared drug-loading polymer micelle powder was mixed with the prescribed amount of mannitol, microcrystalline cellulose, and low-substituted hydroxypropyl cellulose in sequence. Pure water was used as a wetting agent, granulated by 24 mesh sieve, and oven at 50℃ Blast drying, drying the moisture to 1-3%, pass the dried granules through a 24-mesh sieve, weigh them, and calc...

Embodiment 2

[0021] .

[0022] Preparation Process

[0023] The prescription amount of PEG6000-DSPE and paroxetine hydrochloride were fully dissolved in ethanol, and the organic solvent was removed by rotary evaporation under reduced pressure at 37°C for 1 hour in an eggplant-shaped bottle to obtain a uniform film. Add the buffer solution preheated at 37°C and place it in a 37°C water bath. The pot is rotated for hydration, the obtained geopolymer micelles are sized through a 0.45 μm microporous filter membrane, and the filtrate is lyophilized through a freeze dryer to obtain drug-loaded polymer micelle powder.

[0024] The prepared drug-loading polymer micelle powder was mixed with the prescribed amount of mannitol, microcrystalline cellulose, and low-substituted hydroxypropyl cellulose in sequence. Pure water was used as a wetting agent, granulated by 24 mesh sieve, and oven at 50℃ Blast drying, drying the moisture to 1-3%, pass the dried granules through a 24-mesh sieve, weigh them, and calc...

Embodiment 3

[0026] .

[0027] Preparation Process

[0028] The prescription amount of PEG6000-DSPE and paroxetine hydrochloride were fully dissolved in ethanol, and the organic solvent was removed by rotary evaporation under reduced pressure at 37°C for 1 hour in an eggplant-shaped bottle to obtain a uniform film. Add the buffer solution preheated at 37°C and place it in a 37°C water bath. The pot is rotated for hydration, the obtained geopolymer micelles are sized through a 0.45 μm microporous filter membrane, and the filtrate is lyophilized through a freeze dryer to obtain drug-loaded polymer micelle powder.

[0029] The prepared drug-loading polymer micelle powder was mixed with the prescribed amount of mannitol, microcrystalline cellulose, and low-substituted hydroxypropyl cellulose in sequence. Pure water was used as a wetting agent, granulated by 24 mesh sieve, and oven at 50℃ Blast drying, drying the moisture to 1-3%, pass the dried granules through a 24-mesh sieve, weigh them, and calc...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention provides a PEG6000-DSPE-paroxetine hydrochloride composite material, and a preparation method thereof. According to the preparation method, paroxetine hydrochloride and amphiphilic polymeric material PEG6000-DSPE are subjected to self assembling solvent evaporation so as to obtain a polymer micelle, freeze drying technology is adopted for freeze drying of the polymer micelle so as toobtain free dried powder, wet granulation is adopted to prepare the oral disintegrating tablet. The preparation method is capable of improving tablet mouthfeel, increasing main drug stability and dissolution rate, and increasing in vivo bioavailability.

Description

Technical field [0001] The application belongs to the technical field of pharmaceutical preparations, and specifically relates to an orally disintegrating tablet containing a polymer micelle-paroxetine hydrochloride complex and a preparation method thereof. Background technique [0002] Paroxetine hydrochloride tablets are an antidepressant drug developed by GlaxoSmithKline in the United States and approved for marketing in 1992. As a selective serotonin reuptake inhibitor, it exerts an antidepressant effect by increasing the concentration of serotonin in the synaptic cleft. It has a weak effect on other transmitters, and has little effect on the autonomic nervous system and cardiovascular system. It is a selective central nervous system 52 serotonin (52HT) reuptake inhibitor (SSRI). Clinically, it is mainly used to treat depression, but also to treat diseases such as obsessive-compulsive disorder, panic disorder or social anxiety disorder. At present, it, together with fluoxet...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K9/107A61K47/24A61K31/4525A61P25/24
CPCA61K47/24A61K9/0056A61K9/1075A61K9/2031A61K31/4525
Inventor 张迪马莉
Owner 万全万特制药江苏有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com