Dripping pills of paroxetine hydrochloride and its preparation method

A technology for paroxetine hydrochloride and dripping pills is applied in the field of paroxetine hydrochloride dripping pills and their preparation, and can solve the problems of long disintegration time of paroxetine hydrochloride tablets, affecting the therapeutic effect of paroxetine hydrochloride, low dissolution rate and dissolution rate, etc. , to achieve the effect of good compliance, convenient carrying and taking, and improved dissolution rate and dissolution rate

Inactive Publication Date: 2005-01-26
HONGYI SCI & TECH CO LTD NANCHANG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Paroxetine hydrochloride tablet has long disintegration time, low dissolution rate and dissolution rate, poor absorption, low bioavailability, large proportion of excipients, inconvenient taking for children, elderly people, bedridden patients and patients with dysphagia, and poor compliance, which affects the The therapeutic effect of paroxetine hydrochloride

Method used

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  • Dripping pills of paroxetine hydrochloride and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0052] prescription:

[0053] Paroxetine Hydrochloride 5g

[0054] Macrogol 6000 15g

[0055] Makes 1000 capsules

[0056] Preparation method: Take the paroxetine hydrochloride fine powder that has been ultrafinely pulverized and passed through a 200-mesh sieve, add it to the molten polyethylene glycol 6000 matrix, stir well, use simethicone oil as a coolant, make pellets by drop method, and dry to obtain .

example 2

[0058] prescription:

[0059] Paroxetine Hydrochloride 5g

[0060] Macrogol 4000 15g

[0061] Makes 1000 capsules

[0062] Preparation method: Take paroxetine hydrochloride fine powder that has been ultrafinely pulverized and passed through a 200-mesh sieve, add it to the molten polyethylene glycol 4000 matrix, stir well, use simethicone oil as a coolant, make pellets by drop method, and dry to obtain .

example 3

[0064] prescription:

[0065] Paroxetine Hydrochloride 5g

[0066] Macrogol 6000 10g

[0067]Macrogol 4000 5g

[0068] Makes 1000 capsules

[0069] Preparation method: Take paroxetine hydrochloride fine powder that has been ultrafinely pulverized and passed through a 200-mesh sieve, add it to the molten polyethylene glycol 4000 and polyethylene glycol 6000 mixed matrix, stir well, use simethicone oil as a coolant, and drip The legal pills are dried and obtained immediately.

[0070] 4. Example 4

[0071] prescription:

[0072] Paroxetine Hydrochloride 5g

[0073] Glyceryl monostearate 15g

[0074] Makes 1000 capsules

[0075] Preparation method: Take paroxetine hydrochloride fine powder that has been ultrafinely pulverized and passed through a 200-mesh sieve, add it to the molten glyceryl monostearate base, mix well, use ice water as a coolant, make pellets by dropping, dry, and obtain.

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PUM

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Abstract

The invention relates to an Paroxetine Hydrochloride drop pill prepared by utilizing ultramicro disintegration and drop pill manufacturing process, which has the advantages of improving collapse and dissolving speed, dissolving out speed and degree, quick effect, increased medicament stability, reduced adjuvant consumption, lowered production costs, and easiness in carrying and use. oral or swallow administration, It has good compliance, thus is especially suitable for children, the elderly, bedridden patients and dysphagia patients.

Description

technical field [0001] The invention relates to a pharmaceutical preparation and a preparation method thereof, in particular to paroxetine hydrochloride dropping pills and a preparation method thereof. Background technique [0002] Paroxetine hydrochloride is a selective central nervous system serotonin reuptake inhibitor, which can increase the concentration of serotonin in the synaptic cleft and exert antidepressant effect. It has a weak effect on other transmitters and has little effect on the autonomic nervous system and cardiovascular system. [0003] Paroxetine hydrochloride is easily absorbed when taken orally, and is not affected by antacid drugs or food. After taking 30 mg orally, the peak blood concentration is 6.3 hours, and the peak concentration is 17.6 μg / ml, T 1 / 2 For 24 hours, the apparent volume of distribution is 3-28L / kg. The plasma protein binding rate is 95%. The steady-state plasma concentration is reached within 7-14 days, and rapidly distributed to...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K31/443A61P25/24
Inventor 钱进许军彭红李平朱丹刘孝乐
Owner HONGYI SCI & TECH CO LTD NANCHANG
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